PET/MRI vs PET/CT in Head and Neck Imaging: When, Why, and How?

Ryan, Joshua L.; Aaron, Vasantha; Sims, Justin

doi:10.1053/j.sult.2019.07.002

Cited by 19 publications

(10 citation statements)

References 59 publications

(55 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, it has been suggested that the overlap between the ranges of the ADC measurements can potentially be patched by integrating the DWI along with positron emission tomography/computed tomography (PET/CT) to help in the assessment process. Alternatively, positron emission tomography/magnetic resonance imaging (PET/ MRI) can serve as a replacement to PET/CT in the head and neck region [23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Post-treatment benign changes versus recurrence in non-lymphoid head and neck malignancies: can diffusion-weighted magnetic resonance imaging end up the diagnostic challenge?

Serour

Adel

Osman

2020

Egypt J Radiol Nucl Med

View full text Add to dashboard Cite

Background: The aim of this prospective cohort study is to substantiate the added value of diffusion-weighted magnetic resonance imaging (DW-MRI) over conventional MRI assessment in the differentiation between locoregional recurrence/residual tumour and post-treatment benign changes in patients with non-lymphoid head and neck malignancies. Thirty adult patients, each with a suspicious lesion on post-treatment imaging scans at the primary site of a previously treated non-lymphoid head and neck malignancy, were evaluated by MRI and diffusion-weighted imaging (DWI). The apparent diffusion coefficient (ADC) values of the lesions were calculated. Results: Diffusion-weighted MRI yielded an accuracy of 90%, a sensitivity of 88.9%, a specificity of 91.7%, a positive predictive value of 94.1% and a negative predictive value of 84.6%. The mean ADC value of the lesions was lower in the "locoregional recurrence/residual tumour" group (1.08 × 10 −3 mm 2 /s) compared to the "post-treatment benign changes" group (1.95 × 10 −3 mm 2 /s); P < 0.001. An ADC cutoff value of 1.43 × 10 −3 mm 2 /s achieved the same accuracy as the visual assessment by DW-MRI. Conclusion: Incorporating the DWI sequence into the post-treatment imaging assessment protocol brings a substantial added value to conventional MRI assessment in patients with non-lymphoid head and neck malignancies. This valuable merit of DW-MRI can help avoid or, at least, largely minimize unnecessary or unfeasible tissue sampling. An ADC cutoff value of 1.43 × 10 −3 mm 2 /s can also be utilized to aid in the assessment process.

show abstract

Section: Discussionmentioning

confidence: 99%

Post-treatment benign changes versus recurrence in non-lymphoid head and neck malignancies: can diffusion-weighted magnetic resonance imaging end up the diagnostic challenge?

Serour

Adel

Osman

2020

Egypt J Radiol Nucl Med

View full text Add to dashboard Cite

show abstract

“…Numerous oncology studies have compared the diagnostic performance of PET/MRI with PET/ CT. Consensus among these studies is that despite the differences in attenuation correction methods, statistically significant strong positive correlations between SUV measurements from PET/MR and PET/CT exist (64)(65)(66). It is important to note here that a significant underestimation (67) and overestimation (68) of SUV values on the PET/MRI have been reported.…”

Section: Attenuation Correction For Pet In Pet/mrimentioning

confidence: 74%

“…18 F-FDG is taken up non-specifically by all cells that consume glucose including skeletal muscles, which can cause hinderance in the visualization of tracer uptake in the vessel wall. Other tracers, including 64 Cu-DOTATATE (124), 68 Ga-DOTATOC (125), 18 F-Choline (126) and 68 Ga Pentixafor (127), which are more specific for plaque inflammation, have been explored, but still need to be validated in larger studies. 18-fluorine sodium fluoride ( 18 F-NaF) has been used to identify active calcification showing the potential to visualize microcalcifications which are too small to be seen on MRI or CT (128,129).…”

Section: Petmentioning

confidence: 99%

PET/MRI of atherosclerosis

Aizaz¹,

Moonen²,

Pol³

et al. 2020

Cardiovasc Diagn Ther

View full text Add to dashboard Cite

Myocardial infarction and stroke are the most prevalent global causes of death. Each year 15 million people worldwide die due to myocardial infarction or stroke. Rupture of a vulnerable atherosclerotic plaque is the main underlying cause of stroke and myocardial infarction. Key features of a vulnerable plaque are inflammation, a large lipid-rich necrotic core (LRNC) with a thin or ruptured overlying fibrous cap, and intraplaque hemorrhage (IPH). Noninvasive imaging of these features could have a role in risk stratification of myocardial infarction and stroke and can potentially be utilized for treatment guidance and monitoring. The recent development of hybrid PET/MRI combining the superior soft tissue contrast of MRI with the opportunity to visualize specific plaque features using various radioactive tracers, paves the way for comprehensive plaque imaging. In this review, the use of hybrid PET/MRI for atherosclerotic plaque imaging in carotid and coronary arteries is discussed. The pros and cons of different hybrid PET/MRI systems are reviewed. The challenges in the development of PET/MRI and potential solutions are described. An overview of PET and MRI acquisition techniques for imaging of atherosclerosis including motion correction is provided, followed by a summary of vessel wall imaging PET/MRI studies in patients with carotid and coronary artery disease. Finally, the future of imaging of atherosclerosis with PET/ MRI is discussed.

show abstract

“…Although PET/CT and MRI are widely used, to our knowledge they are rarely routinely combined for pretherapeutic staging. In addition, hybrid PET/MRI is an emerging diagnostic tool for head and neck cancers 22,23 . In this work, we focus on the role of PET/CT and MRI, whose detection rates of LNMs are approximately 90% 24,25 …”

Section: Discussionmentioning

confidence: 99%

Multimodal Imaging With Positron Emission Tomography/Computed Tomography and Magnetic Resonance Imaging to Detect Extracapsular Extension in Head and Neck Cancer

et al. 2020

View full text Add to dashboard Cite

Objectives/Hypothesis To assess the ability of specific positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI) features to detect extracapsular extension (ECE) in head and neck squamous cell carcinoma (HNSCC) patients. Study Design Retrospective study in a tertiary certified university cancer institute. Methods We performed a review of patients with advanced HNSCC at Bern University Hospital between 2014 and 2018. Patients with pretherapeutic PET/CT and/or MRI who underwent neck dissection were included, with 212 patients fulfilling inclusion criteria. Blinded evaluation of specific PET/CT and MRI features with respect to presence of ECE was performed. Histopathological examination of neck dissection specimens was used as the gold standard to determine ECE status. Results Out of the 212 included patients, 184 had PET/CT, 186 MRI, and 158 both modalities. Overall clinical stage IV (odds ratio [OR]: 2.26, 95% confidence interval [CI]: 2.25‐11.74), ill‐defined margins in both PET/CT and MRI (OR: 3.48, 95% CI: 1.21‐9.98 and OR: 2.14, 95% CI: 0.94‐4.89, respectively), and a maximum standardized uptake value ≥ 10 (OR: 5.44, 95% CI: 1.21‐9.98) were all significant independent predictors of ECE. When combined, these four features led to a cumulative score able to predict ECE status with an accuracy of 91.43%. Conclusions The current findings indicate specific features in PET/CT and MRI are potential predictors of ECE status and may help in pretherapeutic stratification in HNSCC. Level of Evidence 4 Laryngoscope, 131:E163–E169, 2021

show abstract

PET/MRI vs PET/CT in Head and Neck Imaging: When, Why, and How?

Cited by 19 publications

References 59 publications

Post-treatment benign changes versus recurrence in non-lymphoid head and neck malignancies: can diffusion-weighted magnetic resonance imaging end up the diagnostic challenge?

Post-treatment benign changes versus recurrence in non-lymphoid head and neck malignancies: can diffusion-weighted magnetic resonance imaging end up the diagnostic challenge?

PET/MRI of atherosclerosis

Multimodal Imaging With Positron Emission Tomography/Computed Tomography and Magnetic Resonance Imaging to Detect Extracapsular Extension in Head and Neck Cancer

Contact Info

Product

Resources

About