PET/MRI in practice: a clinical centre survey endorsed by the European Association of Nuclear Medicine (EANM) and the EANM Forschungs GmbH (EARL)

Prakken, Niek H J; Besson, Florent L.; Borra, Ronald; Büther, Florian; Buechel, Ronny R.; Catana, Ciprian; Chiti, Arturo; Dierckx, Rudi; Dweck, Marc R; Erba, Paola Anna; Glaudemans, Andor W J M; Gormsen, Lars Christian; Hristova, Ivalina; Kwee, Thomas C.; Mottaghy, Felix M.; Polycarpou, Irene; Prokop, Mathias; Stegger, Lars; Tsoumpas, Charalampos; Slart, Riemer H. J. A.

doi:10.1007/s00259-023-06308-y

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…In this study, we evaluated the relationship between glucose metabolism and functional connectivity using simultaneously acquired resting‐state 18 F‐FDG‐PET/fMRI and examined their associations with cognitive decline in CN, MCI and AD subjects. The hybrid PET/MRI system allowed us to capture concurrent metabolic and functional changes in relation to AD pathology, providing optimal spatial registration and enhanced patient comfort in a timely‐efficient manner (Chen et al, 2018 ; Prakken et al, 2023 ). Furthermore, considering the rapid changes in mental states over minutes and the swift variations in physiological and metabolic conditions over seconds (Heiss, 2016 ), the combined measurements of FDG uptake and FC were crucial to an accurate evaluation of their interwoven relationship, eliminating the interference caused by intra‐subject variations in physiological and cognitive conditions.…”

Section: Discussionmentioning

confidence: 99%

Topographic metabolism‐function relationships in Alzheimer's disease: A simultaneous PET/MRI study

Li,

Zhang,

Huang

et al. 2024

Human Brain Mapping

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Disruptions of neural metabolism and function occur in parallel during Alzheimer's disease (AD). While many studies have shown diverse metabolic‐functional relationships in specific brain regions, much less is known about how large‐scale network‐level functional activity is associated with the topology of metabolism in AD. In this study, we took the advantages of simultaneous PET/MRI and multivariate analyses to investigate the associations between AD‐related stereotypical spatial patterns (topographies) of glucose metabolism, measured by fluorodeoxyglucose PET, and functional connectivity, measured by resting‐state functional MRI. A total of 101 participants, including 37 patients with AD, 25 patients with mild cognitive impairment (MCI), and 39 cognitively normal controls, underwent PET/MRI scans and cognitive assessments. Three pairs of distinct but optimally correlated metabolic and functional topographies were identified, encompassing large‐scale networks including the default‐mode, executive and control, salience, attention, and subcortical networks. Importantly, the metabolic‐functional associations were not only limited to one‐to‐one‐corresponding regions, but also occur in remote and non‐overlapping regions. Furthermore, both glucose metabolism and functional connectivity, as well as their linkages, exhibited various degrees of disruptions in patients with MCI and AD, and were correlated with cognitive decline. In conclusion, our results support distributed and heterogeneous topographic associations between metabolism and function, which are jeopardized by AD. Findings of this study may deepen our understanding of the pathological mechanism of AD through the perspectives of both local energy efficiency and long‐term interactions between synaptic disruption and functional disconnection contributing to the clinical symptomatology in AD.

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Section: Discussionmentioning

confidence: 99%

Topographic metabolism‐function relationships in Alzheimer's disease: A simultaneous PET/MRI study

Li,

Zhang,

Huang

et al. 2024

Human Brain Mapping

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Recent Progress of Cardiac MRI for Nuclear Medicine Professionals

Choe,

Kim

2024

Nucl Med Mol Imaging

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Diagnostic performance of simultaneous PET-magnetic resonance versus PET-computed tomography in oncology with an overview on clinical utility and referral pattern of PET-magnetic resonance: a single institutional study

Palaniswamy,

Subramanyam

2024

Nuclear Medicine Communications

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Background PET-magnetic resonance (PETMR) imaging is an upcoming investigative modality with a few installations in Asia and only three in India. PET-Computed tomography (PETCT) is an established diagnostic cornerstone for oncological indications but with limited resolution for small lesions due to low soft-tissue contrast and additional radiation exposure. Objective Our primary objective was to evaluate the diagnostic performance of simultaneous PETMR and PETCT in lesion detection in oncological practice. Secondly to assess the referral pattern and study the clinical utility of PETMR in a university hospital practice. Materials and methods A total of 100 consecutive biopsy-proven cancer patients (breast or lung malignancy with suspected metastases) underwent 18F fluorodeoxyglucose (FDG) PETMR and PETCT for staging as a single injection, double examination protocol. Morphological lesion detection on correlative imaging/histopathology was used as the gold standard. Analysing the referral pattern, a total of 9366 patients underwent simultaneous PETMR imaging for indications in the past 5 years since installation. Results 18F FDG PETMR detected 100% of primary tumours in breast/lung carcinoma (Ca) patients while PETCT was positive in 96%. Overall accuracy of nodal metastases detection for PETMR and PETCT was 96 and 88%, while for distant metastases the accuracy was 100 and 93%, respectively. FDG PETMR proved more sensitive and specific than PETCT for regional nodal (P = 0.011 and P < 0.001) and distant metastases detection (P = 0.017 and P < 0.001, respectively). Analysing the general referral pattern for PETMR, the majority were oncology referrals (66.5, 33.5%) when compared to nononcological indications. About 66.24% were FDG based, followed by Ga prostate-specific membrane antigen and dodecane tetraacetic acid. The general utility of PETMR was found incremental in better delineation of small lesions especially in head, neck, liver, brain and gynaecological malignancies. Conclusion In our past 5 years of PETMR practice, we found that simultaneous PETMR is a highly recommended ideal imaging technique for oncological and nononcological indications. It has excellent diagnostic performance with high sensitivity, specificity and accuracy when compared to PETCT in tumour, nodal metastases staging in specific subgroup of breast and lung malignancy patients.

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PET/MRI in practice: a clinical centre survey endorsed by the European Association of Nuclear Medicine (EANM) and the EANM Forschungs GmbH (EARL)

Cited by 3 publications

References 24 publications

Topographic metabolism‐function relationships in Alzheimer's disease: A simultaneous PET/MRI study

Topographic metabolism‐function relationships in Alzheimer's disease: A simultaneous PET/MRI study

Recent Progress of Cardiac MRI for Nuclear Medicine Professionals

Diagnostic performance of simultaneous PET-magnetic resonance versus PET-computed tomography in oncology with an overview on clinical utility and referral pattern of PET-magnetic resonance: a single institutional study

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