PET/MR Technology: Advancement and Challenges

Bogdanović, Borjana; Solari, Esteban; Asiares, Alberto Villagrán; McIntosh, Lachlan; Marwick, Sandra van; Schachoff, Sylvia; Nekolla, Stephan G.

doi:10.1053/j.semnuclmed.2021.11.014

Cited by 13 publications

(6 citation statements)

References 148 publications

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“…6a). Given the tremendous technological efforts made for the development of multimodal scanner [142] and multimodal probes [143] to simultaneously acquire PET and MRI signals, a middle term blue-sky project will most likely consist in evaluating in real time the dynamic interactions between CNS resident microglia and peripheral macrophages, or between microglia and autoreactive B or T cells in NHP models of MS [136]. On top of providing fundamental knowledge on the neuroinflammatory cascades regulating human health, this same technology will undoubtedly prove useful to optimize pharmacological treatments delivery [144] or to track the distribution of myelin specific chimeric antigen receptor T cells (CAR-T) either injected systemically [145] or generated in vivo through viral therapy [146].…”

Section: Multimodality For Complete Investigation Of Nhp Models and C...mentioning

confidence: 99%

Contribution of Intravital Neuroimaging to Study Animal Models of Multiple Sclerosis

et al. 2023

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Multiple sclerosis (MS) is a complex and long-lasting neurodegenerative disease of the central nervous system (CNS), characterized by the loss of myelin within the white matter and cortical fibers, axonopathy, and inflammatory responses leading to consequent sensory-motor and cognitive deficits of patients. While complete resolution of the disease is not yet a reality, partial tissue repair has been observed in patients which offers hope for therapeutic strategies. To address the molecular and cellular events of the pathomechanisms, a variety of animal models have been developed to investigate distinct aspects of MS disease. Recent advances of multiscale intravital imaging facilitated the direct in vivo analysis of MS in the animal models with perspective of clinical transfer to patients. This review gives an overview of MS animal models, focusing on the current imaging modalities at the microscopic and macroscopic levels and emphasizing the importance of multimodal approaches to improve our understanding of the disease and minimize the use of animals.

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Section: Multimodality For Complete Investigation Of Nhp Models and C...mentioning

confidence: 99%

Contribution of Intravital Neuroimaging to Study Animal Models of Multiple Sclerosis

et al. 2023

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“…Compared with PET-CT, PET-MRI offers superior soft tissue contrast, which is excellent for the detection of primary tumors and metastases in soft tissues, and provides a more accurate staging of tumors [79]. In detecting CRC-PM, PET-MRI exhibits similar performance to PET-CT but with higher specificity [80]. However, it is worth noting that although PET-MRI is advantageous in monitoring tumor recurrence, its comprehensive use in clinical practice is hindered by the high radiation dose and examination cost associated with the technology.…”

Section: Pet-mrimentioning

confidence: 99%

Peritoneal Metastasis: A Dilemma and Challenge in the Treatment of Metastatic Colorectal Cancer

Xia,

Geng,

2023

Cancers

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Peritoneal metastasis (PM) is a common mode of distant metastasis in colorectal cancer (CRC) and has a poorer prognosis compared to other metastatic sites. The formation of PM foci depends on the synergistic effect of multiple molecules and the modulation of various components of the tumor microenvironment. The current treatment of CRC-PM is based on systemic chemotherapy. However, recent developments in local therapeutic modalities, such as cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC), have improved the survival of these patients. This article reviews the research progress on the mechanism, characteristics, diagnosis, and treatment strategies of CRC-PM, and discusses the current challenges, so as to deepen the understanding of CRC-PM among clinicians.

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“…74 Nevertheless, none of the proposed metal artifact reduction methods have provided reliable and robust image reconstruction in the context of clinical PET/MR imaging, and as such, this issue warrants further investigation. 3…”

Section: Metal Artefact Reduction Techniquesmentioning

confidence: 99%

“…1,2 In contrast to the widespread adoption of hybrid PET/CT scanners in the clinical setting, PET/MR imaging couldn't reach many sites and may bear only 5% of the total PET market. 3 This trend could be attributed to the high cost and new paradigms introduced by this technology, workflow, and logistics issues, and the challenges associated with quantitative PET/MR imaging. Since the introduction of PET/MRI systems, substantial efforts have been made to find/establish the key clinical applications of this modality in order to justify/promote its utilization.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Positron Emission Tomography/Magnetic Resonance Imaging Technology

Arabi

Zaidi

2023

Magnetic Resonance Imaging Clinics of North America

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PET/MR Technology: Advancement and Challenges

Cited by 13 publications

References 148 publications

Contribution of Intravital Neuroimaging to Study Animal Models of Multiple Sclerosis

Contribution of Intravital Neuroimaging to Study Animal Models of Multiple Sclerosis

Peritoneal Metastasis: A Dilemma and Challenge in the Treatment of Metastatic Colorectal Cancer

Recent Advances in Positron Emission Tomography/Magnetic Resonance Imaging Technology

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