PET/MR Imaging in Head and Neck Cancer

Galgano, Samuel J.; Marshall, Ryan; Middlebrooks, Erik H.; McConathy, Jonathan; Bhambhvani, Pradeep

doi:10.1016/j.mric.2017.08.010

Cited by 20 publications

(7 citation statements)

References 64 publications

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“…[1] Imaging plays a key role in correct diagnosis and tumor staging. [2] The standard conventional imaging modalities for evaluating patients with HNSCC are computed tomography (CT) and magnetic resonance imaging (MRI). Furthermore, Fluorodeoxyglucose-Positron-emission tomography (FDG-PET) is increasingly used in clinical routine to provide information regarding tumor glucose-metabolism.…”

Section: Introductionmentioning

confidence: 99%

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Associations between FDG-PET and Ki 67-index in head and neck cancer

2019

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Background:FDG-PET might be able to reflect histopathology features of tumors. Ki 67 in head and neck carcinomas (HNSCC). The present study sought to elucidate the association between Ki 67 index and SUVmax based upon a large patient sample.Methods:PubMed database was screened for studies analyzed the relationship between Ki 67 and SUV in HNSCC. Nine studies comprising 211 patients were suitable for analysis.Results:SUVmax increased with tumor grade and was statistically significant different between G1, G2, and G3 tumors. The ROC analysis for discrimination between G1/G2 and G3 tumors revealed an area under curve of 0.71. In the overall patient sample, SUVmax correlated statistically significant with Ki 67 index (r = 0.154, P = .032).Conclusion:The present study identified a weak correlation between SUV values and proliferation index Ki 67 index in HNSCC in a large patient sample. Therefore, SUVmax cannot be used as surrogate parameter for proliferation activity in HNSCC.

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Section: Introductionmentioning

confidence: 99%

“…Furthermore, Fluorodeoxyglucose-Positron-emission tomography (FDG-PET) is increasingly used in clinical routine to provide information regarding tumor glucose-metabolism. [2]…”

Section: Introductionmentioning

confidence: 99%

Associations between FDG-PET and Ki 67-index in head and neck cancer

2019

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“…Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent malignancies [ 1 ]. Different imaging modalities like computed tomography (CT) and magnetic resonance tomography (MRI) are used for correct tumor staging in HNSCC [ 2 ]. Nowadays, also functional imaging modalities, such as diffusion-weighted imaging (DWI) can be added into imaging protocol to provide further insight into tumor microstructure [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Different imaging modalities like computed tomography (CT) and magnetic resonance tomography (MRI) are used for correct tumor staging in HNSCC [ 2 ]. Nowadays, also functional imaging modalities, such as diffusion-weighted imaging (DWI) can be added into imaging protocol to provide further insight into tumor microstructure [ 2 ]. Thus, DWI measures random water movement and can be quantified by the apparent diffusion coefficient (ADC) [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Relationships between histogram analysis of ADC values and complex 18F-FDG-PET parameters in head and neck squamous cell carcinoma

Meyer¹,

Purz²,

Sabri³

2018

PLoS ONE

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PurposeHistogram analysis is an emergent imaging technique to further analyze radiological images and to obtain imaging biomarker. In head and neck cancer, MRI and PET are routinely used in clinical practice. The aim of this study was to analyze associations between histogram based ADC parameters and complex FDG-PET derived parameters in head and neck squamous cell carcinoma (HNSCC).Methods34 patients (26% female, mean age, 56.7 ± 10.2 years) with primary HNSCC were prospectively included into the study. ADC histogram parameters were calculated by inhouse made matlab software using a whole lesion measurement. For each tumor, maximum and mean standardized uptake values (SUVmax, SUVmean), Total Lesion Glycolysis (TLG) and Metabolic Tumor Volume (MTV) were determined on PET-images. Spearman's correlation coefficient (ρ) was used to analyze associations between investigated parameters. Benjamini-Hochberg correction was used to adjust for multiple testing. Mann-Whitney test was used for group discrimination. P-values < 0.05 were taken to indicate statistical significance.ResultsThe correlation analysis in the whole tumor group revealed a statistically significant correlation between entropy and MTV as well as TLG (ρ = 0.67, P<0.0001 and ρ = 0.61, P = 0.0002 respectively).There were statistically significant differences between T1/2 and T3/4 tumors in the following parameters: entropy (2.07 ± 0.36 vs 2.61 ± 0.43, P = 0.007), SUVmax (10.79 ± 4.13 vs 17.93 ± 5.89, P = 0.007), SUVmean (6.39 ± 2.48 vs 9.81 ± 4.49, P = 0.01), SUVmin (4.09 ± 1.57 vs 6.34 ± 2.59, P = 0.03), MTV (9.50 ± 7.92 vs 20.36 ± 13.30, P = 0.02), TGU (55.97 ± 39.09 vs 212.3 ± 186.3, P = 0.002).ConclusionThis study showed that entropy derived from ADC maps is strongly associated with MTV and TLG in HNSCC. Entropy, SUVmax, SUVmean, TLG and MTV were statistically significant higher in T3/4 tumors in comparison to T1/2 carcinomas.

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Metastatic Disease in the Head and Neck

Sotoudeh

Choudhary

2021

Hybrid PET/MR Neuroimaging

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PET/MR Imaging in Head and Neck Cancer

Cited by 20 publications

References 64 publications

Associations between FDG-PET and Ki 67-index in head and neck cancer

Associations between FDG-PET and Ki 67-index in head and neck cancer

Relationships between histogram analysis of ADC values and complex 18F-FDG-PET parameters in head and neck squamous cell carcinoma

Metastatic Disease in the Head and Neck

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