Pet Measurements of Glucose Metabolism, Using 11c-Glucose in Patients With Schizophrenia

Widén, L.; Bergstrom, Margit; Blomqvist, G.; Brismar, Torkel; Ehrin, E.; Ericson, Karen L.; Eriksson, L. S.; Greitz, T.; Ingvar, D. H.; Johansson, Lisen; Litton, J-E.; Printz, G; Nilsson, Jonas; Sedvall, Göran; Stone‐Elander, Sharon; Ugglas, M. af; Wiesel, Frits‐Axel

doi:10.1097/00004728-198302000-00085

Cited by 10 publications

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“…The previous study also found a similar effect on intrahemispheric alpha coherence measures (Morrison-Stewart et al 1991). Medication has sometimes resulted in a 'normalizing' effect on the metabolic patterns of schizophrenic patients undergoing PET scans (Widen et al 1983;Szechtman et al 1988) but these findings had not been reported during conditions of cognitive activation until our previous study. The present findings would appear to add further evidence of the' normalization' of coherence measures under conditions of cognitive activation.…”

Section: Discussionsupporting

confidence: 62%

Aberrant interhemispheric alpha coherence on electroencephalography in schizophrenic patients during activation tasks

et al. 1996

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SynopsisThirty schizophrenic patients (20 medicated, 10 off medication) were compared with 30 normal controls subjects matched for age, sex, handedness and intelligence. During the performance of a frontal activation task, normal subjects showed increased interhemispheric coherence between anterior brain regions. Schizophrenic patients did not show the same amount of bilateral anterior activation. During the performance of right hemisphere cognitive activation tasks, normal subjects and medicated schizophrenic patients showed significantly reduced bilateral interhemispheric coherence patterns, while the drug-free schizophrenic patients showed a trend towards this same pattern. It is suggested that these findings provide additional evidence for an aberrant functional organization of the brain in schizophrenia.

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Section: Discussionsupporting

confidence: 62%

Aberrant interhemispheric alpha coherence on electroencephalography in schizophrenic patients during activation tasks

et al. 1996

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“…Their studies have been replicated by some investigators, but not by all (Matthew et al, 1982;Ariel et al, 1983;Our et al, 1985). Buchsbaum et al (1982Buchsbaum et al ( , 1985Buchsbaum et al ( , 1987 have also identified hypofrontality using PET scanning, although this too has not been consistently replicated (Sheppard et al, 1983;Widen et al, 1983). Functional studies have been conducted with increasing methodological sophistication, and more recently, they have involved the use of cognitive challenges in order to determine whether patients with schizophrenia have difficulty in activating specific brain regions.…”

Section: Functional Imaging Techniquesmentioning

confidence: 99%

Neural Mechanisms of Negative Symptoms

Andreasen

1989

Br J Psychiatry

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When Kraepelin originally defined and described dementia praecox, he assumed that it was due to some type of neural mechanism. He hypothesised that abnormalities could occur in a variety of brain regions, including the prefrontal, auditory, and language regions of the cortex. Many members of his department, including Alzheimer and Nissl, were actively involved in the search for the neuropathological lesions that would characterise schizophrenia. Although Kraepelin did not use the term ‘negative symptoms', he describes them comprehensively and states explicitly that he believes the symptoms of schizophrenia can be explained in terms of brain dysfunction:“If it should be confirmed that the disease attacks by preference the frontal areas of the brain, the central convolutions and central lobes, this distribution would in a certain measure agree with our present views about the site of the psychic mechanisms which are principally injured by the disease. On various grounds, it is easy to believe that the frontal cortex, which is specially well developed in man, stands in closer relation to his higher intellectual abilities, and these are the faculties which in our patients invariably suffer profound loss in contrast to memory and acquired ability.” Kraepelin (1919, p. 219)

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“…With regard to schizophrenia, several PET studies have found absolute or relative metabolic hypofrontality in chronic schizophrenic patients, especially when frontal activation tasks were used (Buchsbaum et al 1982(Buchsbaum et al , 1990Farkas et al 1984;Wolkin et al 1985;Volkow et al 1987;Siegel et al 1993). A number of PET studies, however, could not confirm this hypofrontality finding, possibly because some of these studies investigated mainly subacute schizophrenics (Sheppard et al 1983;Widen et al 1983;Volkow et al 1987;Wiesel et al 1987). Other PET studies demonstrated a variety of abnormalities, including hypertemporality (DeLisi et al 1989), a left-right asymmetry of metabolism (Gur et al 1987a(Gur et al , 1987b, and increased (Brodie et al 1984;Wolkin et al 1985) or reduced (Sheppard et al 1983;Buchsbaum et al 1992;Siegel et al 1993) metabolism in the basal ganglia.…”

mentioning

confidence: 99%

Positron Emission Tomography and Fluorodeoxyglucose Studies of Metabolic Hyperfrontality and Psychopathology in the Psilocybin Model of Psychosis

Vollenweider

Leenders

Scharfetter

et al. 1997

Neuropsychopharmacology

371

256

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The effects of the indolehallucinogen psilocybin, a mixed 5-HT2 and 5-HT1 agonist, on regional cerebral glucose metabolism were investigated in 10 healthy volunteers with PET and [F-18]-fluorodeoxyglucose (FDG) prior to and following a 15- or 20-mg dose of psilocybin. Psychotomimetic doses of psilocybin were found to produce a global increase in cerebral metabolic rate of glucose (CMRglu) with significant and most marked increases in the frontomedial and frontolateral cortex (24.3%), anterior cingulate (24.9%), and temporomedial cortex (25.3%). Somewhat smaller increases of CMRglu were found in the basal ganglia (18.5%), and the smallest increases were found in the sensorimotor (14.7%) and occipital cortex (14.4%). The increases of CMRglu in the prefrontal cortex, anterior cingulate, temporomedial cortex, and putamen correlated positively with psychotic symptom formation, in particular with hallucinatory ego disintegration. The present data suggest that excessive 5-HT2 receptor activation results in a hyperfrontal metablic pattern that parallels comparable metabolic findings associated with acute psychotic episodes in chronic schizophrenics and contrasts with the hypofrontality in chronic schizophrenic patients.

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Pet Measurements of Glucose Metabolism, Using 11c-Glucose in Patients With Schizophrenia

Cited by 10 publications

References 0 publications

Aberrant interhemispheric alpha coherence on electroencephalography in schizophrenic patients during activation tasks

Aberrant interhemispheric alpha coherence on electroencephalography in schizophrenic patients during activation tasks

Neural Mechanisms of Negative Symptoms

Positron Emission Tomography and Fluorodeoxyglucose Studies of Metabolic Hyperfrontality and Psychopathology in the Psilocybin Model of Psychosis

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