PET Imaging of Sphingosine-1-Phosphate Receptor 1 with [18F]TZ4877 in Nonhuman Primates
Jiwei Gu,
Ming-Qiang Zheng,
Daniel Holden
et al.
Abstract:Purpose
The sphingosine-1-phosphate receptor-1 (S1PR1) is involved in regulating responses to neuroimmune stimuli. There is a need for S1PR1-specific radioligands with clinically suitable brain pharmcokinetic properties to complement existing radiotracers. This work evaluated a promising S1PR1 radiotracer, [18F]TZ4877, in nonhuman primates.
Procedures:
[18F]TZ4877 was produced via nucleophilic substitution of tosylate precursor with K[18F]/F− followed by deprotection. Brain PET imaging data were acquired wit… Show more
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