PET imaging of focal demyelination and remyelination in a rat model of multiple sclerosis: comparison of [11C]MeDAS, [11C]CIC and [11C]PIB

Faria, Daniele de Paula; Copray, Sjef; Sijbesma, J. W. A.; Willemsen, Antoon T. M.; Buchpiguel, Carlos Alberto; Dierckx, Rudi; Vries, Erik F. J. de

doi:10.1007/s00259-013-2682-6

Cited by 48 publications

(44 citation statements)

References 18 publications

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“…27 To overcome the problem, SUV normalized by reference region has been proposed as a more accurate quantification method for [ 11 C]PIB static imaging. 28 This was not applicable in our case since the reference region is extracted through tissue kinetic clustering thus requiring dynamic imaging.…”

Section: Discussionmentioning

confidence: 99%

Quantification of [¹¹C]PIB PET for Imaging Myelin in the Human Brain: A Test—Retest Reproducibility Study in High-Resolution Research Tomography

Veronese

Bodini

García-Lorenzo

et al. 2015

J Cereb Blood Flow Metab

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An accurate in vivo measure of myelin content is essential to deepen our insight into the mechanisms underlying demyelinating and dysmyelinating neurological disorders, and to evaluate the effects of emerging remyelinating treatments. Recently [(11)C]PIB, a positron emission tomography (PET) tracer originally conceived as a beta-amyloid marker, has been shown to be sensitive to myelin changes in preclinical models and humans. In this work, we propose a reference-region methodology for the voxelwise quantification of brain white-matter (WM) binding for [(11)C]PIB. This methodology consists of a supervised procedure for the automatic extraction of a reference region and the application of the Logan graphical method to generate distribution volume ratio (DVR) maps. This approach was assessed on a test-retest group of 10 healthy volunteers using a high-resolution PET tomograph. The [(11)C]PIB PET tracer binding was shown to be up to 23% higher in WM compared with gray matter, depending on the image reconstruction. The DVR estimates were characterized by high reliability (outliers <1%) and reproducibility (intraclass correlation coefficient (ICC) >0.95). [(11)C]PIB parametric maps were also found to be significantly correlated (R(2)>0.50) to mRNA expressions of the most represented proteins in the myelin sheath. On the contrary, no correlation was found between [(11)C]PIB imaging and nonmyelin-associated proteins.

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Section: Discussionmentioning

confidence: 99%

Quantification of [¹¹C]PIB PET for Imaging Myelin in the Human Brain: A Test—Retest Reproducibility Study in High-Resolution Research Tomography

Veronese

Bodini

García-Lorenzo

et al. 2015

J Cereb Blood Flow Metab

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“…Sites of inflammation in MS are often hypoxic and acidic (33, 52, 53) and, accordingly, tissue from MS lesions exhibits hypoxic markers, including increased expression of glucose transporters (GLUTs) and monocarboxylate transporters (MCT), compared with healthy patients (54), most likely due to increased glycolysis of activated MPs. The increased avidity for glucose by MS lesions can be exploited for diagnostic purposes, since these lesions uptake substantial amounts of the glucose analog [ 18 F]-fluorodeoxyglucose, which can be visualized by positron emission tomography during neuroimaging exams (55). In line with these findings, tissue hypoxia and the corresponding increased expression of HIF-1α develops rapidly in response to inflammation in white and gray matter of animals subject to EAE.…”

Section: Metabolic Reprograming Of Mps In Msmentioning

confidence: 99%

Metabolic Reprograming of Mononuclear Phagocytes in Progressive Multiple Sclerosis

et al. 2015

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Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS). Accumulation of brain damage in progressive MS is partly the result of mononuclear phagocytes (MPs) attacking myelin sheaths in the CNS. Although there is no cure yet for MS, significant advances have been made in the development of disease modifying agents. Unfortunately, most of these drugs fail to reverse established neurological deficits and can have adverse effects. Recent evidence suggests that MPs polarization is accompanied by profound metabolic changes, whereby pro-inflammatory MPs (M1) switch toward glycolysis, whereas anti-inflammatory MPs (M2) become more oxidative. It is therefore possible that reprograming MPs metabolism could affect their function and repress immune cell activation. This mini review describes the metabolic changes underpinning macrophages polarization and anticipates how metabolic re-education of MPs could be used for the treatment of MS.Key points: Inflammation in progressive MS is mediated primarily by MPs.Cell metabolism regulates the function of MPs.DMAs can re-educate the metabolism of MPs to promote healing.

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“…In MS, this low uptake of PiB in the cerebellar region would complicate the detection of lesions since demyelinated lesions show decreased signal compared to intact myelin. A study comparing different radio tracers for PET by de Paula Faria et al [33] found that the radio tracer MeDAS has more favorable properties than PiB for quantitative PET imaging of demyelinated and remyelinated lesions throughout the CNS. MeDAS showed a higher uptake than PiB in white matter regions, and in the healthy cerebellum and brainstem it was significantly higher than PiB.…”

Section: Importance Of Early Prediction Of Msmentioning

confidence: 99%

Role of Amyloid from a Multiple Sclerosis Perspective: A Literature Review

Chandra¹

2015

Neuroimmunomodulation

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The traditional concept of multiple sclerosis (MS), that it is primarily a white matter inflammatory disease, has changed a great deal. Thanks to the recent development witnessed in MS research, a whole new idea has emerged that MS is a neurodegenerative disease, and neurodegeneration occurs rather earlier in the pathological process. This has also led to the foundation of the hypothesis that two fundamentally different diseases, Alzheimer's disease (AD) and MS, may share a common mechanism of neurodegeneration. Conventionally, amyloid is thought to be a consequence of protein misfolding and aggregation and is most notorious for its association with debilitating and chronic human diseases. Amyloid is implicated to be related with the deterioration and progression of AD. The finding of amyloid precursor protein expression in axons around the plaque in MS, as well as the correlation of amyloid-β (Aβ) with different stages of MS, has clearly indicated that amyloid plays some kind of key role in MS disease pathogenesis. Excitingly, a paradoxical phenomenon of Aβ has also been observed in several studies recently. It has been shown that amyloid might actually be helping in ameliorating the inflammatory effect in diseases like AD and MS. Amyloid imaging allows earlier diagnosis of MS by taking advantage of the relation of amyloid with MS. This will have a big impact on patient diagnosis and management. In this review I have included the findings of research studies dating from several years back to the most recent ones. Through this review I have tried to show the critical role of amyloid in MS and the importance of investigating through PET imaging.

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PET imaging of focal demyelination and remyelination in a rat model of multiple sclerosis: comparison of [11C]MeDAS, [11C]CIC and [11C]PIB

Cited by 48 publications

References 18 publications

Quantification of [¹¹C]PIB PET for Imaging Myelin in the Human Brain: A Test—Retest Reproducibility Study in High-Resolution Research Tomography

Quantification of [¹¹C]PIB PET for Imaging Myelin in the Human Brain: A Test—Retest Reproducibility Study in High-Resolution Research Tomography

Metabolic Reprograming of Mononuclear Phagocytes in Progressive Multiple Sclerosis

Role of Amyloid from a Multiple Sclerosis Perspective: A Literature Review

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PET imaging of focal demyelination and remyelination in a rat model of multiple sclerosis: comparison of [11C]MeDAS, [11C]CIC and [11C]PIB

Cited by 48 publications

References 18 publications

Quantification of [11C]PIB PET for Imaging Myelin in the Human Brain: A Test—Retest Reproducibility Study in High-Resolution Research Tomography

Quantification of [11C]PIB PET for Imaging Myelin in the Human Brain: A Test—Retest Reproducibility Study in High-Resolution Research Tomography

Metabolic Reprograming of Mononuclear Phagocytes in Progressive Multiple Sclerosis

Role of Amyloid from a Multiple Sclerosis Perspective: A Literature Review

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Quantification of [¹¹C]PIB PET for Imaging Myelin in the Human Brain: A Test—Retest Reproducibility Study in High-Resolution Research Tomography

Quantification of [¹¹C]PIB PET for Imaging Myelin in the Human Brain: A Test—Retest Reproducibility Study in High-Resolution Research Tomography