PET Imaging of Estrogen Receptors Using 18F-Based Radioligands

Kumar, Manoj; Salem, Kelley; Jeffery, Justin J.; Fowler, Amy M.

doi:10.1007/978-1-0716-1920-9_9

Cited by 3 publications

(4 citation statements)

References 91 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another promising avenue for further research might be assessment of 18F-fuoro-17β-estradiol and 18F-fuoro-5α-dihydrotestosterone given the impact of sex hormones on cardiovascular health 75,76 …”

Section: Future Directionsmentioning

confidence: 99%

“…Another promising avenue for further research might be assessment of 18F-fuoro-17β-estradiol and 18Ffuoro-5α-dihydrotestosterone given the impact of sex hormones on cardiovascular health. 75,76 In conclusion, ischemic heart disease is a leading cause of morbidity and mortality for women around the world. There are sex-specific differences in the pathophysiology of CAD development in women, which necessitates sex-specific diagnostic workup (Fig.…”

Section: Future Directionsmentioning

confidence: 99%

See 1 more Smart Citation

Approach to Imaging Ischemia in Women

Parwani

Mohammad

Liberman

et al. 2023

Journal of Thoracic Imaging

View full text Add to dashboard Cite

Approach to imaging ischemia in women Coronary artery disease in women tends to have a worse short-and long-term prognosis relative to men and remains the leading cause of mortality worldwide. Both clinical symptoms and diagnostic approach remain challenging in women due to lesser likelihood of women presenting with classic anginal symptoms on one hand and underperformance of conventional exercise treadmill testing in women on the other. Moreover, a higher proportion of women with signs and symptoms suggestive of ischemia are more likely to have nonobstructive coronary artery disease (CAD) that requires additional imaging and therapeutic considerations. New imaging techniques such as coronary computed tomography (CT) angiography, CT myocardial perfusion imaging, CT functional flow reserve assessment, and cardiac magnetic resonance imaging carry substantially better sensitivity and specificity for the detection of ischemia and coronary artery disease in women. Familiarity with various clinical subtypes of ischemic heart disease in women and with the major advantages and disadvantages of advanced imaging tests to ensure the decision to select one modality over another is one of the keys to successful diagnosis of CAD in women. This review compares the 2 major types of ischemic heart disease in womenobstructive and nonobstructive, while focusing on sex-specific elements of its pathophysiology.

show abstract

Section: Future Directionsmentioning

confidence: 99%

Section: Future Directionsmentioning

confidence: 99%

Approach to Imaging Ischemia in Women

Parwani

Mohammad

Liberman

et al. 2023

Journal of Thoracic Imaging

View full text Add to dashboard Cite

show abstract

“…The last decade has witnessed the development of PET probes targeting sex hormone receptors in women with gynecological cancers, such as 18 F-fluoro-17β-estradiol and 18 F-fluoro-5α-dihydrotestosterone [ 223 , 224 ]. Given the impact of sex hormones on cardiovascular health, the use of such probes potentially constitutes an interesting research tool in the field of gender-specific medicine.…”

Section: Future Directionsmentioning

confidence: 99%

Imaging of heart disease in women: review and case presentation

Mikaïl

Rossi

Bengs

et al. 2022

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

Cardiovascular diseases (CVD) remain the leading cause of mortality worldwide. Although major diagnostic and therapeutic advances have significantly improved the prognosis of patients with CVD in the past decades, these advances have less benefited women than age-matched men. Noninvasive cardiac imaging plays a key role in the diagnosis of CVD. Despite shared imaging features and strategies between both sexes, there are critical sex disparities that warrant careful consideration, related to the selection of the most suited imaging techniques, to technical limitations, and to specific diseases that are overrepresented in the female population. Taking these sex disparities into consideration holds promise to improve management and alleviate the burden of CVD in women. In this review, we summarize the specific features of cardiac imaging in four of the most common presentations of CVD in the female population including coronary artery disease, heart failure, pregnancy complications, and heart disease in oncology, thereby highlighting contemporary strengths and limitations. We further propose diagnostic algorithms tailored to women that might help in selecting the most appropriate imaging modality.

show abstract

“…Thus ER imaging can potentially be used for breast cancer screening, staging, and response evaluation and for guiding therapies [ 49 , 50 ]. Many techniques have been developed to detect ligand–ER interactions, including PET [ 51 , 52 ] and fluorescence imaging [ 53 , 54 ].…”

Section: Introductionmentioning

confidence: 99%

Cell Uptake of Steroid-BODIPY Conjugates and Their Internalization Mechanisms: Cancer Theranostic Dyes

Amendoeira

Luz

Valente

et al. 2023

IJMS

View full text Add to dashboard Cite

Estradiol-BODIPY linked via an 8-carbon spacer chain and 19-nortestosterone- and testosterone-BODIPY linked via an ethynyl spacer group were evaluated for cell uptake in the breast cancer cell lines MCF-7 and MDA-MB-231 and prostate cancer cell lines PC-3 and LNCaP, as well as in normal dermal fibroblasts, using fluorescence microscopy. The highest level of internalization was observed with 11β-OMe-estradiol-BODIPY 2 and 7α-Me-19-nortestosterone-BODIPY 4 towards cells expressing their specific receptors. Blocking experiments showed changes in non-specific cell uptake in the cancer and normal cells, which likely reflect differences in the lipophilicity of the conjugates. The internalization of the conjugates was shown to be an energy-dependent process that is likely mediated by clathrin- and caveolae-endocytosis. Studies using 2D co-cultures of cancer cells and normal fibroblasts showed that the conjugates are more selective towards cancer cells. Cell viability assays showed that the conjugates are non-toxic for cancer and/or normal cells. Visible light irradiation of cells incubated with estradiol-BODIPYs 1 and 2 and 7α-Me-19-nortestosterone-BODIPY 4 induced cell death, suggesting their potential for use as PDT agents.

show abstract

PET Imaging of Estrogen Receptors Using 18F-Based Radioligands

Cited by 3 publications

References 91 publications

Approach to Imaging Ischemia in Women

Approach to Imaging Ischemia in Women

Imaging of heart disease in women: review and case presentation

Cell Uptake of Steroid-BODIPY Conjugates and Their Internalization Mechanisms: Cancer Theranostic Dyes

Contact Info

Product

Resources

About