PET/CT imaging of neuroendocrine tumors with <sup>68</sup>Gallium-labeled somatostatin analogues: An overview and single institutional experience from India

Sharma, Punit; Singh, Harmandeep; Bal, Chandrasekhar; Kumar, Rakesh

doi:10.4103/0972-3919.125760

Cited by 45 publications

(19 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This method has several advantages over traditional imaging, namely improved spatial resolution/tumour localization, cheaper to use (no need for cyclotron), less time to image and ability to measure the level of uptake. 17 Unfortunately, this newer technique was unavailable at our institution; traditional indium-111 Octreotide scan was performed which demonstrated diffuse uptake of radiotracer in the pancreas particularly in the T 2 hyperintense masses, consistent with the favoured neuroendocrine tumour rather than chronic pancreatitis. 9 …”

Section: Discussionmentioning

confidence: 93%

Imitators of chronic pancreatitis: diffuse neuroendocrine tumour of the pancreas

et al. 2017

View full text Add to dashboard Cite

We report a rare case of diffuse replacement of the pancreas with neuroendocrine tumour mimicking chronic pancreatitis. A 55-year-old female with no significant past medical history initially presented with abdominal pain in 2006. A CT of the abdomen and pelvis was performed, revealing diffuse pancreatic parenchymal calcifications with mild pancreatic ductal dilatation and no discrete mass. She was diagnosed with chronic pancreatitis and followed clinically until 2015, where she presented with recurrent abdominal pain. A repeat CT and MRI of the abdomen were performed which revealed new hypoenhancing masses within the pancreas, particularly in the pancreatic tail. There was a persistent background of pancreatic parenchymal calcifications. The possibility of pancreatic neuroendocrine tumour was raised, and an indium-111 Octreotide scan was recommended. Diffuse intense uptake was identified throughout the pancreas on the indium-111 imaging. Given the concern for neuroendocrine tumour, a total pancreatectomy was performed, with histopathology revealing replacement of the pancreas with coalescing well-circumscribed nodules. Many of the nodules had numerous calcifications and localized amyloid deposition. Immunohistochemical stains of the neoplastic cells were strong for neuroendocrine markers chromogranin A and synaptophysin. Overall the findings were consistent with numerous neuroendocrine tumours of the pancreas, Grade II, as per the 2010 WHO criteria for neuroendocrine tumours of the pancreas. Neuroendocrine tumours of the pancreas are lesions that arise from the islet cells, with an approximate incidence of five cases per million people per year. Only one other case report has been documented in the literature by Singh et al demonstrating diffuse pancreatic neuroendocrine tumour replacing the entire pancreas. As diffuse pancreatic neuroendocrine tumour can look similar on imaging to chronic pancreatitis or other infiltrative processes, we wanted to present this case and some of the more specific imaging findings in distinguishing these entities.

show abstract

Section: Discussionmentioning

confidence: 93%

Imitators of chronic pancreatitis: diffuse neuroendocrine tumour of the pancreas

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In 2016, the US Food and Drug Administration approved the use of a new radioactive tracer, 68 gallium dotatate, for PET imaging in order to localize somatostatin receptor-positive NETs. Better results have been achieved using this tracer than those obtained using conventional SRS (343536) because the spatial resolution of PET/CT is better than that of single photon emission computed tomography (SPECT) and its affinity for the receptor is higher than that of octreotide.…”

Section: Updates Regarding Pancreatic Nensmentioning

confidence: 99%

What Is New in the 2017 World Health Organization Classification and 8th American Joint Committee on Cancer Staging System for Pancreatic Neuroendocrine Neoplasms?

Choe

Kim

et al. 2019

Korean J Radiol

View full text Add to dashboard Cite

The diagnosis and management of pancreatic neuroendocrine neoplasms (NENs) have evolved significantly in recent years. There are several diagnostic and therapeutic challenges and controversies regarding the management of these lesions. In this review, we focus on the recent significant changes and controversial issues regarding the diagnosis and management of NENs and discuss the role of imaging in the multidisciplinary team approach.

show abstract

“…Studies have shown the superiority of Ga-68-DOTA peptide PET/CT imaging over conventional SRS. [17] In a study that included 109 patients with gastroenteropancreatic NETs, Ga-68-DOTA-NOC PET/CT showed sensitivity and specificity of 78.3% and 92.5%, respectively, for primary tumor and 97.4% and 100% for metastases. It was better than a conventional imaging modality for the detection of both primary tumor ( P < 0.001) and metastases ( P < 0.0001).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of technetium-99m-octreotide in imaging neuroendocrine tumors, Oman hospital experience with literature review

et al. 2019

View full text Add to dashboard Cite

The aim of this observational cross-sectional study with retrospective review of the data is to evaluate the efficacy of using technetium-99m-octreotide (Tc-99m-OCT) in imaging neuroendocrine tumors (NETs) in our tertiary care hospital. A total of 58 patients had Tc-99m-OCT were identified in our database, from January 2013 to December 2016. Forty-one patients (age range of 15–75 years) meet our inclusion criteria, namely histopathology proven NETs, Tc-99m-OCT scan, computed tomography (CT), or magnetic resonance imaging (MRI) done in our institute for correlation. Twenty-three patients had true positive Tc-99m-OCT scan. In addition to the primary tumors, the octreotide scan revealed metastasis in the lung, liver, and retroperitoneal lymph nodes. The smallest lesion detected on octreotide scan was a 4-mm pulmonary nodule that was missed on lung window CT scan. The Tc-99m-OCT had 17 true negative, one false negative, and no false positive. The CT and MRI scans had 18 true positive, 17 true negative, 5 false negative, and one false positive. The overall sensitivity, specificity, accuracy, positive, and negative predictive values of Tc-99m-OCT scan were 96%, 100%, 97%, 100%, and 94%, respectively. Whereas those of CT and MRI were 78%, 94%, 85%, 94%, and 77%, respectively. Our diagnostic accuracy of Tc-99m-OCT is high. We recommend that, in addition to the conventional radiological investigations, Tc-99m-OCT scan, or other somatostatin receptor imaging (SSR) is a mandate for better and accurate staging of patients with NETs.

show abstract

PET/CT imaging of neuroendocrine tumors with ⁶⁸Gallium-labeled somatostatin analogues: An overview and single institutional experience from India

Cited by 45 publications

References 87 publications

Imitators of chronic pancreatitis: diffuse neuroendocrine tumour of the pancreas

Imitators of chronic pancreatitis: diffuse neuroendocrine tumour of the pancreas

What Is New in the 2017 World Health Organization Classification and 8th American Joint Committee on Cancer Staging System for Pancreatic Neuroendocrine Neoplasms?

Diagnostic accuracy of technetium-99m-octreotide in imaging neuroendocrine tumors, Oman hospital experience with literature review

Contact Info

Product

Resources

About

PET/CT imaging of neuroendocrine tumors with 68Gallium-labeled somatostatin analogues: An overview and single institutional experience from India

Cited by 45 publications

References 87 publications

Imitators of chronic pancreatitis: diffuse neuroendocrine tumour of the pancreas

Imitators of chronic pancreatitis: diffuse neuroendocrine tumour of the pancreas

What Is New in the 2017 World Health Organization Classification and 8th American Joint Committee on Cancer Staging System for Pancreatic Neuroendocrine Neoplasms?

Diagnostic accuracy of technetium-99m-octreotide in imaging neuroendocrine tumors, Oman hospital experience with literature review

Contact Info

Product

Resources

About

PET/CT imaging of neuroendocrine tumors with ⁶⁸Gallium-labeled somatostatin analogues: An overview and single institutional experience from India