PET/CT Imaging of Lung Cancer

Abstract

Fluoro-deoxyglucose positron emission tomography (PET) imaging has a diagnostic and prognostic value in the initial staging, restaging, and surveillance of non-small-cell lung cancer (NSCLC). When used in conjunction with conventional radiologic imaging, PET imaging has been shown to result in significant changes in clinical management of NSCLC. Specifically, baseline PET imaging can improve initial staging and guide surgical and radiotherapy planning, whereas repeat PET imaging after the initiation of chemoradiotherapy can predict tumor response and help tailor therapy. After the end of definitive treatment, PET has greater diagnostic accuracy than other imaging modalities for the detection of tumor recurrence. The recent development of fused PET/CT imaging has improved the radiologic evaluation of NSCLC patients by combining metabolic and anatomic imaging; however, this has resulted in more complexity in the image interpretation. It is important for the interpreting physician to understand the role PET/CT plays in the staging, assessment of treatment, and follow-up after therapy in the multidisciplinary management of patients with NSCLC.

Usefulness of fluoro-2-deoxyglucose positron emission tomography for investigating unexplained rising carcinoembryonic antigen levels that occur during the postoperative surveillance of lung cancer patients

“…8 The specifi city of an FDG-PET scan after defi nitive treatment is lower than that at the initial staging visit because any infl ammatory changes associated with treatment will lead to an increased uptake on the scan. 9 However, FDG-PET still shows a high sensitivity for the detection of recurrent disease, especially of unexpected distant metastases. With a carefully designed protocol which includes the selective use of FDG-PET, this sophisticated scanning technique should prove to be a powerful tool for the detection of recurrent disease or a metachronous tumor.…”

In Vivo Imaging of64Cu-Labeled Polymer Nanoparticles Targeted to the Lung Endothelium

“…In contrast, nanomaterials can be appropriately labeled for MRI; however, the lungs are often poorly visualized with MRI because lung density is low compared with other soft tissues and because susceptibility artifacts resulting from the many air-tissue interfaces further reduce the MR signal (17). PET, instead, is a highly sensitive and quantitative imaging method that has been used repeatedly to image several lung functions, in both preclinical and clinical settings (18)(19)(20)(21). Furthermore, the positron-emitting radionuclide 64 Cu has already been used to successfully image NP distribution in vivo, in both healthy animals (22) and disease models (23,24).…”

Hamartoma pulmonar como diagnóstico diferencial de metástase de carcinoma de mama: relato de caso

“…(4) If a diagnosis has not been made, since percutaneous biopsy is not nary metastases have been studied. Positron emission computed tomography using glucose marked with fluoride 18, which is an imaging method with high specificity for malignant diseases, (16) can be cited as an example. Another equally important ally is immunohistochemical study, which can be performed in biopsy specimens and also differentiates those three entities; thyroid transcription factor 1 monoclonal antibody, which is one of the markers of primary lung carcinoma, is worthy of mention.…”