PET-CT Fusion in Radiation Management of Patients with Anorectal Tumors

Anderson, C.; Koshy, Mary; Staley, Charles A.; Esiashvili, Natia; Ghavidel, S.; Fowler, Zach; Fox, Tim; Esteves, Fábio; Landry, Jerome C.; Godette, Karen

doi:10.1016/j.ijrobp.2007.02.055

Cited by 72 publications

(39 citation statements)

References 10 publications

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“…Only a few published studies evaluated PET/CT in the management of primary rectal tumors. Initial data suggest that PET/CT has a potential to detect metastatic disease or disease outside standard radiation fields and may alter clinical outcomes through more appropriate selection of treatment strategies [1,8].…”

Section: Introductionmentioning

confidence: 99%

Impact of 18F-FDG-PET/CT on Staging and Irradiation of Patients with Locally Advanced Rectal Cancer

et al. 2009

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Section: Introductionmentioning

confidence: 99%

Impact of 18F-FDG-PET/CT on Staging and Irradiation of Patients with Locally Advanced Rectal Cancer

et al. 2009

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“…Published data also suggest improvements in the imaging of esophageal, cervical, and rectal cancers (21,22). For colorectal cancers, PET/CT is frequently used in the initial staging of tumors, evaluation of treatment response, and detection of tumor recurrence.…”

Section: Discussionmentioning

confidence: 99%

Is there any impact of PET/CT on radiotherapy planning in rectalcancer patients undergoing preoperative IMRT?

Kılıç¹,

Çatlı²,

Ülger³

et al. 2015

Turk J Med Sci

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Background/aim: To investigate the effect of positron emission tomography-computed tomography (PET/CT)-based contouring on dosimetric parameters in rectal cancer patients undergoing preoperative intensity-modulated radiation therapy (IMRT). Materials and methods:Preoperative radiation therapy plans with conformal radiotherapy (CRT) or IMRT were created and examined according to the CT-and PET/CT-based contouring of 20 rectal cancer patients, retrospectively. Results:The target volumes delineated with PET/CT were significantly larger than the volumes created by CT (P = 0.043). Dose delivered to 98% of the planning target volume was high in IMRT planning contouring with CT and PET/CT compared with CRT planning, but the difference was not statistically significant (P = 0.056). Percent volumes receiving 105% of dose and 110% of dose were low in IMRT planning when compared with CRT (P < 0.0001 and P = 0.044, respectively). The volumes receiving 45 Gy for the small intestine, femur heads, and bladder and the maximum dose received by the bladder were significantly lower in IMRT. Conclusion:We showed that the target volumes created with PET/CT are significantly larger than the target volumes created with CT and that IMRT provides lower radiation exposure to the tumor-free tissues compared to the CRT planning. The dosimetric results primarily favor IMRT planning in rectal cancer patients and consequently present the significant alteration in target volumes.

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“…Positron emission tomography (PET) scanning as an adjunct to CT identifies sites of metastasis not observed on CT in 25 % of cases [25]. Almost 20 % of patients with inguinal nodes that are negative on both physical examination and CT scan are positive on PET [26].…”

Section: Diagnosismentioning

confidence: 99%

“…PET/CT proved useful in initial staging perirectal/pelvic or inguinal lymph nodes, causing a change in radiation fields in 16-35 % of patients [25][26][27][28][29]. However, upstaging related to lymph node metastases might have been overestimated, as up to 31 % of inguinal metastases identified by PET/CT are reportedly false positives [30].…”

Section: Diagnosismentioning

confidence: 99%

The treatment of squamous anal carcinoma: guidelines of the Italian society of colo-rectal surgery

2012

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The Italian society of colo-rectal surgery (SICCR) is dedicated to improving the study, prevention and management of the diseases of the colon, rectum and anus. One of the aims of the society is to establish guidelines to the treatment of these diseases. These guidelines are based on the international literature and on the best available evidence. Clinical practice guidelines are one of the most important instruments to provide therapeutic decision-making support, based on the best scientific evidence available at the time. Guidelines are advisory and not prescriptive, susceptible to continual variations secondary to innovations and new scientific evidence. These guidelines are a guide for all colo-rectal surgeons and physicians who approach anal cancer.

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PET-CT Fusion in Radiation Management of Patients with Anorectal Tumors

Cited by 72 publications

References 10 publications

Impact of 18F-FDG-PET/CT on Staging and Irradiation of Patients with Locally Advanced Rectal Cancer

Impact of 18F-FDG-PET/CT on Staging and Irradiation of Patients with Locally Advanced Rectal Cancer

Is there any impact of PET/CT on radiotherapy planning in rectalcancer patients undergoing preoperative IMRT?

The treatment of squamous anal carcinoma: guidelines of the Italian society of colo-rectal surgery

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