PET/CT for Lymphoma Post-therapy Response Assessment in Other Lymphomas, Response Assessment for Autologous Stem Cell Transplant, and Lymphoma Follow-up

Karls, Shawn; Shah, Hina; Jacene, Heather A.

doi:10.1053/j.semnuclmed.2017.09.004

Cited by 26 publications

(16 citation statements)

References 98 publications

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“…Traditional diagnostic imaging modalities employed for the staging of appendicular osteosarcoma in the dog include long bone and thoracic radiography, abdominal ultrasound, whole‐body skeletal scintigraphy, and/or contrast‐enhanced whole‐body CT (CE‐WBCT) 3 . Positron emission tomography (PET) is utilized in both human and veterinary medicine to improve the diagnosis of primary, recurrent, metastatic, and comorbid malignancies, and to monitor tumor response to treatment 16–20 . Like all forms of diagnostic nuclear medicine, PET imaging provides physiologic information with a high degree of sensitivity, but is limited in its ability to yield a high degree of specificity and precise anatomic information.…”

Section: Introductionmentioning

confidence: 99%

“…3 Positron emission tomography (PET) is utilized in both human and veterinary medicine to improve the diagnosis of primary, recurrent, metastatic, and comorbid malignancies, and to monitor tumor response to treatment. [16][17][18][19][20] Like all forms of diagnostic nuclear medicine, PET imaging provides physiologic information with a high degree of sensitivity, but is limited in its ability to yield a high degree of specificity and precise anatomic information. To increase spatial resolution and overall diagnostic specificity, positron emission tomographic imaging can be combined with CT (PET/CT) that offers enhanced anatomic information.…”

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confidence: 99%

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The use of fluorine‐18‐fluorodeoxyglucose‐positron emission tomography/computed tomography as an effective method for staging in dogs with primary appendicular osteosarcoma

Crooks

Randall

Griffin

2021

Vet Radiology Ultrasound

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Fluorine-18-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography/computed tomography (PET/CT) has been utilized in veterinary medicine to improve the detection and characterization of primary, recurrent, and secondary neoplasms; but its use as a staging tool for dogs diagnosed with appendicular osteosarcoma has not been published. The purpose of this retrospective, case series, descriptive study was to detail the use of 18 F-FDG PET/CT for staging a population of dogs with appendicular osteosarcoma, report the detection rate of secondary neoplastic lesions, and compare findings with published detection rates for other historically used imaging modalities.Seventy-one client-owned dogs with a confirmed diagnosis of appendicular osteosarcoma and staged with a whole-body 18 F-FDG PET/CT scan near the time of initial diagnosis were included. Each PET/CT study was re-evaluated for malignancy distinct from the primary disease entity based on a collective qualitative and quantitative assessment of 18 F-FDG uptake, CT appearance, and contrast enhancement characteristics.Following re-evaluation of each study, information pertaining to tissue sampling performed on identified lesions was retrieved from the medical record when available.Staging with 18 F-FDG PET/CT identified 17 of 71 (23.9%) and 12 of 71 (16.3%) dogs with a high suspicion or confirmation of a metastatic or comorbid malignant neoplasm respectively, with eight of 71 (11.3%) having both metastatic and comorbid lesions. The results of this study are suggestive that 18 F-FDG PET/CT is effective in identifying both osseous and soft tissue secondary neoplastic lesions in dogs afflicted with appendicular osteosarcoma, yielding an increased detection rate of all lesions compared those previously reported for skeletal scintigraphy or whole-body CT.

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

The use of fluorine‐18‐fluorodeoxyglucose‐positron emission tomography/computed tomography as an effective method for staging in dogs with primary appendicular osteosarcoma

Crooks

Randall

Griffin

2021

Vet Radiology Ultrasound

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“…Wahl et al recommend in the PET Response Criteria in Solid Tumors (PERCIST) that liver SUV changes should not exceed 20 % in the 18 F-FDG PET/ CT images before and after when they are compared to evaluate a patient's response to a tumor therapy [5]. In the Deauville 5-point scoring, a method to assess response to lymphoma treatment, responses in different treatment phases are assessed by comparing the FDG distributions in the disease lesion, mediastinal blood pool, and the liver [24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Effects of Fever on 18F-FDG Distribution In Vivo: a Preliminary Study

Cheng

et al. 2020

Mol Imaging Biol

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Purpose: Elevated body temperature might change glucose metabolism in human organs. The purpose of this study is to explore 18 F-FDG distribution in febrile patients on the day of 18 F-FDG PET/CT scanning and compare it with patients with a normal temperature. Procedures: 18 F-FDG PET/CT was performed on 69 febrile patients and 82 patients with a normal temperature. Patient sociodemographic data, blood glucose levels before PET/CT, body temperature on the day of the exam, and laboratory test results were collected. Maximal standard uptake values (SUV max ) in the brain, mediastinal blood pool, liver, spleen, and the bone marrow were compared. Results: Compared with the controls, SUV max of the febrile patients was significantly lower in the brain, mediastinal blood pool, and the liver (p G 0.01), and higher in the spleen and bone marrow (p G 0.01). In the febrile group, SUV max was not significantly different between the FDG burden and non-FDG burden patients (p 9 0.05). Body temperature was found negatively correlated with SUV max in the brain (r = − 0.646), mediastinal blood pool (r = − 0.530), and the liver (r = − 0.384), and positively correlated with the SUV max in the spleen (r = 0.592) and bone marrow (r = 0.651). Multivariate linear regression established body temperature on the day of PET/CT as an independent affecting factor (p G 0.01) for the SUV max in the brain, mediastinal blood pool, liver, spleen, and bone marrow. The SUV in the brain, liver, and mediastinal blood pool remained different (p G 0.05) after corrected with the SUV max in the blood pool or liver. Conclusions: Fever influences 18 F-FDG distribution in multiple human tissues and organs. Altered 18 F-FDG distribution in vivo might affect results of disease lesion detection and tumor therapy response assessment. Correction with blood pool or liver SUV fails to cancel the effects of fever. The day of fever should be avoided for PET/CT scan, especially in assessing tumor therapy response.

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“…18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography (PET)/computed tomography (CT) plays a key role in staging, response assessment and prediction of prognosis in DLBCL (6). However, the prognostic value of 18 F-FDG PET/CT in patients with DLBCL receiving HDC followed by auto-HSCT is still controversial (7). Our previous studies showed that post-HSCT PET/CT assessment was the main predictor of outcomes in DLBCL patients (8,9).…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of 18F-fluorodeoxyglucose positron emission tomography using Deauville criteria in diffuse large B cell lymphoma treated with autologous hematopoietic stem cell transplantation

Ying¹,

Mi²,

Zhou³

et al. 2019

Chinese Journal of Cancer Research

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ObjectiveHigh-dose chemotherapy (HDC) followed by autologous hematopoietic stem cell transplantation (auto-HSCT) plays an important role in improving outcomes of diffuse large B cell lymphoma (DLBCL) patients. 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) has been widely accepted in response assessment and prediction of prognosis in DLBCL. Here, we report the value of 18F-FDG PET/CT pre- and post-HSCT in predicting outcomes of patients with DLBCL. MethodsDLBCL patients who had PET/CT scan before and after HSCT were included. PET results were interpreted based upon Deauville criteria. The prognostic value of 18F-FDG PET/CT in auto-HSCT was evaluated. ResultsEighty-four patients were enrolled. In univariate analysis, pre- and post-HSCT PET findings were correlated with 3-year progression-free survival (PFS) [hazard ratio (HR)=4.391, P=0.001; HR=7.607, P<0.001] and overall survival (OS) (HR=4.792, P=0.008; HR=26.138, P<0.001). Patients receiving upfront auto-HSCT after first-line treatment had better outcomes than relapsed/refractory DLBCL patients (3-year PFS, P<0.001; 3-year OS, P<0.001). In the relapsed/refractory patients, pre- and post-HSCT PET findings were also associated with 3-year PFS (P=0.003vs. P<0.001) and OS (P=0.027vs. P<0.001). A significant correlation was observed between clinical response to chemotherapy before auto-HSCT and outcomes of patients in the entire cohort (3-year PFS, P<0.001; 3-year OS, P<0.001) and in the subgroup of 21 patients with positive pre-HSCT PET (3-year PFS, P=0.084; 3-year OS, P=0.240). A significant association between survival and post-HSCT PET findings was observed in multivariate analysis (HR=5.168, P<0.001). ConclusionsPET results before and after HSCT are useful prognostic factors for DLBCL patients receiving HSCT. Patients who responded to chemotherapy, even those with positive pre-HSCT PET, are appropriate candidates for auto-HSCT.

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PET/CT for Lymphoma Post-therapy Response Assessment in Other Lymphomas, Response Assessment for Autologous Stem Cell Transplant, and Lymphoma Follow-up

Cited by 26 publications

References 98 publications

The use of fluorine‐18‐fluorodeoxyglucose‐positron emission tomography/computed tomography as an effective method for staging in dogs with primary appendicular osteosarcoma

The use of fluorine‐18‐fluorodeoxyglucose‐positron emission tomography/computed tomography as an effective method for staging in dogs with primary appendicular osteosarcoma

Effects of Fever on 18F-FDG Distribution In Vivo: a Preliminary Study

Prognostic value of 18F-fluorodeoxyglucose positron emission tomography using Deauville criteria in diffuse large B cell lymphoma treated with autologous hematopoietic stem cell transplantation

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