PET/CT and PET/MRI, Normal Variations, and Artifacts

Beheshti, Mohsen; Manafi‐Farid, Reyhaneh; Rezaee, Alireza

doi:10.1007/978-3-030-39457-8_17

Cited by 3 publications

(2 citation statements)

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“…However, other mechanisms may be involved in PCa cells [ 45 ]. Two major radiotracers of choline have been commonly used in clinical practice, [ 11 C]choline and [ 18 F]choline [ 46 ].…”

Section: Targeting Agentsmentioning

confidence: 99%

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Molecular Imaging in Primary Staging of Prostate Cancer Patients: Current Aspects and Future Trends

Manafi‐Farid

Ranjbar

Araghi

et al. 2021

Cancers

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Accurate primary staging is the cornerstone in all malignancies. Different morphological imaging modalities are employed in the evaluation of prostate cancer (PCa). Regardless of all developments in imaging, invasive histopathologic evaluation is still the standard method for the detection and staging of the primary PCa. Magnetic resonance imaging (MRI) and computed tomography (CT) play crucial roles; however, functional imaging provides additional valuable information, and it is gaining ever-growing acceptance in the management of PCa. Targeted imaging with different radiotracers has remarkably evolved in the past two decades. [111In]In-capromab pendetide scintigraphy was a new approach in the management of PCa. Afterwards, positron emission tomography (PET) tracers such as [11C/18F]choline and [11C]acetate were developed. Nevertheless, none found a role in the primary staging. By introduction of the highly sensitive small molecule prostate-specific membrane antigen (PSMA) PET/CT, as well as recent developments in MRI and hybrid PET/MRI systems, non-invasive staging of PCa is being contemplated. Several studies investigated the role of these sophisticated modalities in the primary staging of PCa, showing promising results. Here, we recapitulate the role of targeted functional imaging. We briefly mention the most popular radiotracers, their diagnostic accuracy in the primary staging of PCa, and impact on patient management.

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“…However, other mechanisms may be involved in PCa cells [ 45 ]. Two major radiotracers of choline have been commonly used in clinical practice, [ 11 C]choline and [ 18 F]choline [ 46 ].…”

Section: Targeting Agentsmentioning

confidence: 99%

“…Ultimately, in a meta-analysis, Beheshti et al showed a pooled lesion-based sensitivity of 75.1% (95% CI: 69.8–79.8%) and specificity of 75.8% (95% CI: 72.4–78.9%) for the detection of primary tumor [ 12 ]. In the patient-based manner the pooled sensitivity was 93.0% (95% CI: 90.0–96.0%) [ 46 ].…”

Section: Targeting Agentsmentioning

confidence: 99%