PET/CT and Brain MRI role in Staging NSCLC: Prospective Assessment of the Accuracy, Reliability and Cost–effectiveness

Abstract

Aim:To determine whether PET/CT and brain MRI used in staging NSCLC can be accurate, reliable and cost-effective tools. NSCLC represents 80–85% of lung cancer and adequate information on the initial tumor staging is critical for planning an optimal therapeutic strategy.Patients & methods:Data from 30 newly diagnosed NSCLC patients in Greece were collected and prospectively recorded. Patients with potential resectable disease were evaluated to ensure that there are no detectable metastases that would rule out the possibility of a curative surgery.Results:Divergence occurred in 50% of cases of staging with CT or PET/CT alone, while metastases undetectable by the CT were revealed using PET/CT. Unnecessary thoracotomies were avoided by 10% of patients and another 10% was operated on after chemotherapy with a better prognosis.Conclusion:PET/CT and brain MRI combined are reliable for correct staging, reducing avoidable thoracotomies, morbidity rates and costs.

Circ_ZNF124 promotes non-small cell lung cancer progression by abolishing miR-337-3p mediated downregulation of JAK2/STAT3 signaling pathway

“…Since early stages of lung cancer does not cause any signs and symptoms, the diagnosis is usually made at advanced stages of the disease, thus, the overall 5 year survival rate is pretty low with only around 20% [3, 30]. NSCLC is a subtype of lung cancer with a poor prognosis [12]. Approximately, 85% of lung cancer cases are NSCLC [2, 27].…”

CT Combined with Multiparameter MRI in Differentiating Pathological Subtypes of Non‐Small‐Cell Lung Cancer before Surgery

“…CT and MRI are currently the main noninvasive imaging methods for the diagnosis of NSCLC lesions. The former, with high temporal, spatial, and contrast resolution, can show the size, morphology, and location of any lung tumor and is able to detect unfiltered lymph nodes with cancer cells [ 22 ]. Nevertheless, CT has ionizing radiation and a low detection rate of small lesions.…”

“…At present, it has been stated that DW-MRI plays an equivalent role to CT in detecting tumor volume in NSCLC patients after chemotherapy and can even reliably determine the range of radiation-induced lung toxicity [ 26 ]. Gkogkozotou et al [ 22 ] have found that the combination of PET/CT and brain MRI is beneficial to accurately classifying the stages of NSCLC and reduce avoidable thoracotomy. One study has discovered that the CT-based radiomics model can predict malignancy in pulmonary nodules (<1 cm) [ 27 ].…”

Princípios básicos e aplicações oncológicas da PET-CT/18F-FDG

“…Segundo Lowe et al 24 , os achados de estadiamento tumoral pela PET-CT/ 18 F-FDG alterou o plano de tratamento cirúrgico em 22% dos pacientes diagnosticados com carcinoma de células escamosas de cabeça e pescoço. O estadiamento tumoral pela PET-CT/ 18 F-FDG também contribui para a redução de cirurgias desnecessárias, como toracotomias ligadas a lesões pulmonares 25 ou laparotomias exploratórias em pacientes diagnosticados com câncer de estômago 26 , dentre outras.…”