PET-Computed Tomography in Veterinary Medicine

Randall, Elissa

doi:10.1016/j.cvsm.2015.12.008

Cited by 27 publications

(89 citation statements)

References 19 publications

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“…Semi‐quantitative analysis of FDG uptake was reported as the maximum, minimum, mean, and SD of SUV in regions of interest (ROI) within the area of maximal radionuclide activity (Figure ). Normal skeletal muscles in dogs typically show mild homogeneous FDG uptake with maximum SUV of approximately 1.0 . Areas with radionuclide uptake greater than background or corresponding anatomy in the contralateral limb were evaluated for concurrent CT abnormalities (eg, change in density, size, or enhancement) and considered suspect for a pathologic condition or increased normal metabolic activity based on references established in normal canine studies .…”

Section: Methodsmentioning

confidence: 99%

“…Normal skeletal muscles in dogs typically show mild homogeneous FDG uptake with maximum SUV of approximately 1.0 . Areas with radionuclide uptake greater than background or corresponding anatomy in the contralateral limb were evaluated for concurrent CT abnormalities (eg, change in density, size, or enhancement) and considered suspect for a pathologic condition or increased normal metabolic activity based on references established in normal canine studies . At each of the anatomical locations, a planar ROI was drawn with the lesion extent determined by the radiologist in the image plane that best demonstrated the area of interest and the minimum, maximum, mean, and SD values for PET SUV were recorded for objective, quantifiable evaluation.…”

Section: Methodsmentioning

confidence: 99%

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Fluorine‐18‐fluoro‐2‐deoxy‐d‐glucose PET‐CT aids in detection of soft‐tissue injuries for dogs with thoracic or pelvic limb lameness

Frank

Mann

Duerr

2019

Vet Radiology Ultrasound

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Fluorine-18-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) provides physiologic images of tissues based on their glucose metabolism. The combination of FDG PET and CT (FDG PET-CT) has been utilized in human musculoskeletal imaging to localize soft tissue lesions, however, this modality has not been thoroughly investigated for the diagnosis of canine lameness. This prospective, descriptive study evaluated FDG PET-CT findings in 25 client-owned dogs with inconclusive origin of thoracic or pelvic limb lameness (thoracic limb n = 15/25, 60%; pelvic limb n = 6/25, 24%; and combination of both limbs n = 4/25, 16%). We hypothesized that FDG PET-CT would aid the detection of soft tissue lesions not visible with other imaging modalities. Combined FDG PET-CT detected soft tissue lesions in 40% (n = 10/25) and osteoarthritis in 64% (n = 16/25) of the patients. FDG PET detected more soft tissue lesions than contrastenhanced CT (n = 15/15, 100% and n = 12/15, 80%, respectively), while CT identified more osteoarthritis lesions than FDG PET (n = 26/26, 100% and n = 18/26, 69%, respectively). The three imaging-diagnoses based on the FDG PET component included the following: flexor carpi ulnaris muscle tear, psoas major myopathy, and tarsal desmopathy. No diagnosis for the lameness was obtained in three dogs. Findings supported FDG PET-CT as a useful adjunct imaging modality for detection of certain soft tissue injuries of the musculoskeletal system. Combined FDG PET-CT should be considered for cases where the cause of lameness is thought to be of soft tissue origin and cannot be diagnosed by conventional means. K E Y W O R D S functional imaging, myopathy, PET tracer, SUVmax, tendinopathy

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Fluorine‐18‐fluoro‐2‐deoxy‐d‐glucose PET‐CT aids in detection of soft‐tissue injuries for dogs with thoracic or pelvic limb lameness

Frank

Mann

Duerr

2019

Vet Radiology Ultrasound

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“…During the 1‐h uptake a whole body CT scan (pre‐ and postcontrast) was obtained, immediately followed by whole body positron emission tomography scan, typically using eight to nine 18.0 cm frames with 1.5–3 min per bed. Computed tomography attenuation‐corrected images and non‐attenuation‐corrected images of the Positron emission tomography data were reconstructed using the line‐of‐response row‐action maximum likelihood algorithm method …”

Section: Methodsmentioning

confidence: 99%

Pilot study utilizing Fluorine‐18 fluorodeoxyglucose‐positron emission tomography/computed tomography for glycolytic phenotyping of canine mast cell tumors

Griffin

Thamm

Selmic

et al. 2018

Vet Radiology Ultrasound

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The goal of this prospective pilot study was to use naturally occurring canine mast cell tumors of various grades and stages as a model for attempting to determine how glucose uptake and markers of biologic behavior are correlated. It was hypothesized that enhanced glucose uptake, as measured by 2-[fluorine-18]fluoro-d-glucose-positron emission tomography/computed tomography (F18 FDG PET-CT), would correlate with histologic grade. Dogs were recruited for this study from a population referred for treatment of cytologically or histologically confirmed mast cell tumors. Patients were staged utilizing standard of care methods (abdominal ultrasound and three view thoracic radiographs), followed by a whole body F18 FDG PET-CT. Results of the F18 FDG PET-CT were analyzed for possible metastasis and standard uptake value maximum (SUV ) of identified lesions. Incisional or excisional biopsies of the accessible mast cell tumors were obtained and histology performed. Results were then analyzed to look for a possible correlation between the grade of mast cell tumors and SUV . A total of nine animals were included in the sample. Findings indicated that there was a correlation between grade of mast cell tumors and SUV as determined by F18 FDG PET-CT (p-value = 0.073, significance ≤ 0.1). Based on the limited power of this study, it is felt that further research to examine the relationship between glucose utilization and biologic aggressiveness in canine mast cell tumors is warranted. This study was unable to show that F18 FDG PET-CT was a better staging tool than standard of care methods.

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“…Początkowo badania PET były wykonywane jednocześnie z badaniami tomograficznymi, z wykorzystaniem różnych urządzeń, a ich łączona analiza była możliwa dzięki wykorzystaniu specjalnych oprogramowań scalających (42). Obecnie prawie wszystkie dostępne skanery pozytonowej tomografii emisyjnej są urządzeniami hybrydowymi typu: PET-CT, w połączeniu z wielorzędowym tomografem komputerowym, lub PET-MRI -z rezonansem magnetycznym (9,23,26,27,43,58). Pozwoliło to na mniejsze obciążenie pacjenta promieniowaniem niż w przypadku osobnego wykorzystania metody PET i tomografii komputerowej, a także na zwiększenie dokładności badania dzięki dodatkowemu obrazowaniu aspektów anatomicznych (9,10,21,57).…”

Section: Zasada Działania Petunclassified

“…Pozytonowa tomografia emisyjna (PET, positron emission tomography) jest innowacyjną techniką obrazowania z zakresu medycyny nuklearnej, polegającą na wykorzystaniu skanera PET, który bez zastosowania zewnętrznego źródła promieniowania rentgenowskiego lub radioaktywnego rejestruje promieniowanie powstające podczas anihilacji pozytonów (anty-elektronów). Wymaga to wykorzystania radiofarmaceutyków emitujących w ciele badanego pacjenta pozytony, czyli dodatnio naładowane elektrony, zwane również cząstkami beta + (31,43,55), dzięki czemu ta metoda pozwala na wykonanie szybkiego, bezbolesnego i bezpiecznego badania ciała pacjenta. Podczas badania jednocześnie wykonywane jest skanowanie PET, przedstawiające wychwyt zgromadzonego w ciele znacznika oraz tomografia komputerowa, obrazująca struktury anatomiczne ciała.…”

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Use of positron emission tomography in medicine and veterinary medicine

Łojszczyk-Szczepaniak

Dębiak

Jarząbek-Bielecka

et al. 2020

Medycyna Weterynaryjna

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Positron emission tomography (PET) is an imaging technique using positron (anti-electron) radiopharmaceuticals, in which radiation generated during the annihilation of positrons is recorded. This method is used in oncology, neurology and cardiology. PET is of particular importance to oncology, in both scientific and clinical research, especially in the identification and staging of metastatic disease, as well as in therapy planning and control. The use of PET has contributed to the advancement of research into many neurological problems. Data in the literature indicate that PET is widely used in veterinary medicine. PET allows for detailed evaluation of many oncologic and fungal diseases. In neurology, it has been used in necrotizing meningoencephalitis and epilepsy. There have been a number of experimental studies in cardiology, as well, in patients after radiation therapy.

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PET-Computed Tomography in Veterinary Medicine

Cited by 27 publications

References 19 publications

Fluorine‐18‐fluoro‐2‐deoxy‐d‐glucose PET‐CT aids in detection of soft‐tissue injuries for dogs with thoracic or pelvic limb lameness

Fluorine‐18‐fluoro‐2‐deoxy‐d‐glucose PET‐CT aids in detection of soft‐tissue injuries for dogs with thoracic or pelvic limb lameness

Pilot study utilizing Fluorine‐18 fluorodeoxyglucose‐positron emission tomography/computed tomography for glycolytic phenotyping of canine mast cell tumors

Use of positron emission tomography in medicine and veterinary medicine

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