PET and SPECT Imaging of Brain Tumors

Zhang, Jessica; Traylor, Katie; Mountz, James M.

doi:10.1053/j.sult.2020.08.007

Cited by 11 publications

(13 citation statements)

References 30 publications

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“…This improved anatomical detail helps to improve the accuracy of biopsies and allows better outlining of tumor margins in edematous brain tissue, thus improving therapeutic targeting, and histological diagnostic accuracy. [ 266 ]…”

Section: Brain Tumor Imagingmentioning

confidence: 99%

“…99m Tc‐MIBI was found to be more than 87% accurate in discriminating surviving/necrotic tumors after treatment, and with higher signal‐to‐noise ratio and improved tumor margin definition, it can perform an important role in challenging tumor grade related assessments. [ 266,269 ]…”

Section: Brain Tumor Imagingmentioning

confidence: 99%

“…Although MRI is the best imaging modality to characterize brain tumors, CT remains the imaging modality of choice to evaluate bone structures and neurological deficits due to its rapid imaging capabilities and wide availability, especially when MRI is contraindicated (e.g., magnetic pacemakers). [266] PET radiolabeled amino acids, including carbon 11 -methionine (C 11 -MET), l-3,4-dihydroxy-6-[F 18 ]phenylalanine (F 18 -DOPA), F 18 -fluoro-ethyl-tyrosine (F 18 -FET), and fluoro 18 -fluorodeoxyglucose (F 18 -FDG), and they enter the BBB via CMT. [267,268] C 11 -MET has limited clinical application due to its 20-minute half-life and cyclotron dependence, and F 18 is more commercially viable.…”

Section: Positron Emission Tomography/electron Computed Tomography (P...mentioning

confidence: 99%

“…99m Tc-MIBI was found to be more than 87% accurate in discriminating surviving/necrotic tumors after treatment, and with higher signal-to-noise ratio and improved tumor margin definition, it can perform an important role in challenging tumor grade related assessments. [266,269] Another commonly used lipophilic particle complex is 99m Tc-tetrofosmin (TF), which like 99m Tc-MIBI uses active diffusion into the brain, but its uptake is dependent on membrane potential and proportional to local blood flow, and the radiotracer is also present only in surviving tumors. Schillaci et al evaluated the potential use of SPECT/CT in clinical applications, mapping it to clinical course and MRI findings, with scintillation spectral data considered as true positive or true negative.…”

Section: Single-photon Emission Computed Tomography/ct (Spect/ct)mentioning

confidence: 99%

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Micro‐Nanocarriers Based Drug Delivery Technology for Blood‐Brain Barrier Crossing and Brain Tumor Targeting Therapy

Wang

Shi

Jiang

et al. 2022

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His research interests include translational studies in the development of new therapies and biomarkers for prognosis and prediction of therapy, and mechanism investigation of treatment resistance in lymphoma. Yinyan Wang is a neurosurgeon and doctoral supervisor at Beijing Tiantan Hospital, and he is a principal investigator for the National Research Center of Neurological Diseases, a principal investigator for China Institute for Brain Research, Beijing. He focused on the individualized precise treatment of gliomas, and he published 72 papers in this field. Lin Feng is an associate professor/doctoral supervisor of Beihang University, "Beijing New Star of Science and Technology." He is a member of the IEEE International Technical Committee on Micro and Nano Robotics, a member of the SCI-indexed journal "Bio-Design and Manufacturing," "Frontiers in Robotics and AI," Science cooperative journal "Cyborg and Bionic Systems." He has published more than 115 academic papers and one textbook on "Introduction to Micro and Nano Robotics." His research interests include precision technology and medical fundamental research on targeted drug delivery field-controlled micro-nanorobots, which is supported by the National Key R&D Program for Intelligent Robotics.

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Section: Brain Tumor Imagingmentioning

confidence: 99%

Section: Brain Tumor Imagingmentioning

confidence: 99%

Section: Positron Emission Tomography/electron Computed Tomography (P...mentioning

confidence: 99%

Section: Single-photon Emission Computed Tomography/ct (Spect/ct)mentioning

confidence: 99%

See 2 more Smart Citations

Micro‐Nanocarriers Based Drug Delivery Technology for Blood‐Brain Barrier Crossing and Brain Tumor Targeting Therapy

Wang

Shi

Jiang

et al. 2022

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“…Nonetheless, there has been an expanding role of PET-CT in neuro oncology. In addition to FDG, several radiopharmaceuticals have been developed and used to assess important biologic and physiologic properties of brain tumors including metabolism, proliferation, blood flow/perfusion, hypoxia, amino acid uptake, somatostatin-receptor expression [ 99 , 100 , 101 , 102 , 103 , 104 , 105 ]. Expanded neuro oncologic applications for a variety of radiopharmaceuticals, including those FDA-approved for other indications, is well supported in the literature.…”

Section: Neuro Oncologymentioning

confidence: 99%

PET-CT in Clinical Adult Oncology—V. Head and Neck and Neuro Oncology

Wiggins

Hoffman

Fine

et al. 2022

Cancers

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PET-CT is an advanced imaging modality with many oncologic applications, including staging, assessment of response to therapy, restaging, and longitudinal surveillance for recurrence. The goal of this series of six review articles is to provide practical information to providers and imaging professionals regarding the best use of PET-CT for specific oncologic indications, and the potential pitfalls and nuances that characterize these applications. In addition, key tumor-specific clinical information and representative PET-CT images are provided to outline the role that PET-CT plays in the management of oncology patients. Hundreds of different types of tumors exist, both pediatric and adult. A discussion of the role of FDG PET for all of these is beyond the scope of this review. Rather, this series of articles focuses on the most common adult malignancies that may be encountered in clinical practice. It also focuses on FDA-approved and clinically available radiopharmaceuticals, rather than research tracers or those requiring a local cyclotron. The fifth review article in this series focuses on PET-CT imaging in head and neck tumors, as well as brain tumors. Common normal variants, key anatomic features, and benign mimics of these tumors are reviewed. The goal of this review article is to provide the imaging professional with guidance in the interpretation of PET-CT for the more common head and neck malignancies and neuro oncology, and to inform the referring providers so that they can have realistic expectations of the value and limitations of PET-CT for the specific type of tumor being addressed.

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Fundamental in Polymer-/Nanohybrid-Based Nanorobotics for Theranostics

Patil

Lim

2022

Nanorobotics and Nanodiagnostics in Integrative Biology and Biomedicine

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PET and SPECT Imaging of Brain Tumors

Cited by 11 publications

References 30 publications

Micro‐Nanocarriers Based Drug Delivery Technology for Blood‐Brain Barrier Crossing and Brain Tumor Targeting Therapy

Micro‐Nanocarriers Based Drug Delivery Technology for Blood‐Brain Barrier Crossing and Brain Tumor Targeting Therapy

PET-CT in Clinical Adult Oncology—V. Head and Neck and Neuro Oncology

Fundamental in Polymer-/Nanohybrid-Based Nanorobotics for Theranostics

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