PET and SPECT Imaging of Steroid Hormone Receptors

Abstract

Steroid hormones like estrogens, progestins, androgens, and corticosteroids are involved in normal brain function. They are able to exert both neuroprotective and neurotrophic effects. In addition, steroid hormones play a crucial role in

In vivo imaging of brain androgen receptors in rats: a [ 18 F]FDHT PET study

“…16β-[ 18 F]fluoro-5α-dihydrotestosterone ([ 18 F]FDHT) is an 18 F-labeled androgen derivative that has been used successfully as a PET tracer for imaging of AR expression in rats, baboons and patients with prostate cancer. However, there are no studies reported yet on the use of [ 18 F]FDHT PET for imaging of AR expression in the brain [8]. The aim of this study was therefore to investigate the feasibility of AR imaging in the rat brain using [ 18 F]FDHT PET.…”