PET and SPECT Imaging in Veterinary Medicine

LeBlanc, Amy K.; Peremans, Kathelijne

doi:10.1053/j.semnuclmed.2013.08.004

Cited by 22 publications

(29 citation statements)

References 65 publications

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“…Both positron emission tomography and positron emission tomography/CT have been used in human medicine for multiple purposes including the following: staging and restaging of cancer, assessment of vascular perfusion, assessment of inflammatory disease, determining a cause for fever of unknown origin, and monitoring response to therapy after treatment of neoplastic, inflammatory, or infectious disease . The radiopharmaceutical 18 F‐FDG is commonly used as the radiotracer for positron emission tomography.…”

Section: Discussionmentioning

confidence: 99%

“…The attached radioactive 18 F can be detected and localized by its emissions in a positron emission tomography scanner. Increased glycolysis in malignant or inflamed tissue results in increased 18 F‐FDG uptake compared to benign lesions and normal tissues . In infectious and inflammatory conditions, glucose transporters (GLUT 1 and GLUT3) and glycolytic enzymes become overexpressed leading to increased glucose consumption .…”

Section: Discussionmentioning

confidence: 99%

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¹⁸F‐FDG‐PET/CT as adjunctive diagnostic modalities in canine fever of unknown origin

Grobman

Cohn

Knapp

et al. 2017

Vet Radiology Ultrasound

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Fever of unknown origin (FUO) is a persistent or recurrent fever for which the underlying source has not been identified despite diagnostic investigation. In people, F-fluoro-2-deoxyglucose positron emission tomography ( F-FDG-PET) alone or in combination with computed tomography (CT) is often beneficial in detecting the source of fever when other diagnostics have failed. Veterinary reports describing use of these modalities in animals with fever of unknown origin are currently lacking. Aims of this retrospective case series were to describe F-FDG-PET or F-FDG-PET/CT findings in a group of dogs with fever of unknown origin. Dogs presenting to a single center between April 2012 and August 2015 were included. A total of four dogs met inclusion criteria and underwent either positron emission tomography (n = 2) or positron emission tomography/CT (n = 2) as a part of their diagnostic investigation. All subjects underwent extensive diagnostic testing prior to F-FDG-PET/CT. Initial diagnostic evaluation failed to identify either a cause of fever or an anatomic location of disease in these four dogs. In each dog, positron emission tomography or positron emission tomography/CT was either able to localize or rule out the presence of focal lesion thereby allowing for directed sampling and/or informed disease treatment. Follow up F-FDG-PET/CT scans performed in two patients showed improvement of observed abnormalities (n = 1) or detected recurrence of disease allowing for repeated treatment before clinical signs recurred (n = 1). Fever resolved after specific treatment in each dog. Findings from the current study supported the use of positron emission tomography or positron emission tomography/CT as adjunctive imaging modalities for diagnosis and gauging response to therapy in dogs with fever of unknown origin.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

¹⁸F‐FDG‐PET/CT as adjunctive diagnostic modalities in canine fever of unknown origin

Grobman

Cohn

Knapp

et al. 2017

Vet Radiology Ultrasound

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“…Changes such as fibrosis and tumor recurrence can be difficult to distinguish on CT and MR; functional imaging with PET may help clarify differences and alter future therapy. Currently in veterinary medicine, 2‐deoxy‐2‐[ 18 F]‐fluoro‐deoxyglucose (FDG), 3′‐deoxy‐3′‐[ 18 F]‐fluorothymidine (FLT), and copper(II)‐diacetyl‐bis (N4‐methylthiosemicarbazone) (Cu‐ATSM) have been used to assess various neoplastic conditions in dogs and cats . In particular, several studies have evaluated functional imaging over time in an attempt to correlate pretreatment scans to posttreatment scans; ideal comparisons would require registration of image datasets to avoid interpretation errors .…”

Section: Image Registrationmentioning

confidence: 99%

“…Currently in veterinary medicine, 2-deoxy-2-[ 18 F]-fluoro-deoxyglucose (FDG), 3 -deoxy-3 -[ 18 F]-fluorothymidine (FLT), and copper(II)-diacetyl-bis (N4-methylthiosemicarbazone) (Cu-ATSM) have been used to assess various neoplastic conditions in dogs and cats. [61][62][63][64][65][66][67][68][69][70] In particular, several studies have evaluated functional imaging over time in an attempt to correlate pretreatment scans to posttreatment scans; ideal comparisons would require registration of image datasets to avoid interpretation errors. [67][68][69][70] One study that assessed preradiation therapy FDG, FLT, and Cu-ATSM PET/CT scans to posttreatment FDG PET/CT scans demonstrated the complexity and utility of registration methods in dogs with sinonasal tumors.…”

Section: Current State Of Image Registration In Veterinary Radiation mentioning

confidence: 99%

Invited Review—image Registration in Veterinary Radiation Oncology: Indications, Implications, and Future Advances

Feng

Lawrence

Cheng

et al. 2016

Vet Radiology Ultrasound

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The field of veterinary radiation therapy (RT) has gained substantial momentum in recent decades with significant advances in conformal treatment planning, image-guided radiation therapy (IGRT), and intensity-modulated (IMRT) techniques. At the root of these advancements lie improvements in tumor imaging, image alignment (registration), target volume delineation, and identification of critical structures. Image registration has been widely used to combine information from multimodality images such as computerized tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) to improve the accuracy of radiation delivery and reliably identify tumor-bearing areas. Many different techniques have been applied in image registration. This review provides an overview of medical image registration in RT and its applications in veterinary oncology. A summary of the most commonly used approaches in human and veterinary medicine is presented along with their current use in IGRT and adaptive radiation therapy (ART). It is important to realize that registration does not guarantee that target volumes, such as the gross tumor volume (GTV), are correctly identified on the image being registered, as limitations unique to registration algorithms exist. Research involving novel registration frameworks for automatic segmentation of tumor volumes is ongoing and comparative oncology programs offer a unique opportunity to test the efficacy of proposed algorithms.

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“…A tomografia por emissão de pósitrons (PET) é um método diagnóstico de imagem que usa compostos marcados com radioisótopos como sondas moleculares para visualizar e medir processos bioquímicos in vivo (75,76) . Alguns exemplos destes processos bioquímicos são: o fluxo do sangue, o uso do oxigênio e o metabolismo da glicose (77) .…”

Section: Pet E Chcunclassified

Efeito do sorafenibe na carcinogênese hepática experimental secundária à doença hepática gordurosa não alcoólica

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PET and SPECT Imaging in Veterinary Medicine

Cited by 22 publications

References 65 publications

¹⁸F‐FDG‐PET/CT as adjunctive diagnostic modalities in canine fever of unknown origin

¹⁸F‐FDG‐PET/CT as adjunctive diagnostic modalities in canine fever of unknown origin

Invited Review—image Registration in Veterinary Radiation Oncology: Indications, Implications, and Future Advances

Efeito do sorafenibe na carcinogênese hepática experimental secundária à doença hepática gordurosa não alcoólica

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PET and SPECT Imaging in Veterinary Medicine

Cited by 22 publications

References 65 publications

18F‐FDG‐PET/CT as adjunctive diagnostic modalities in canine fever of unknown origin

18F‐FDG‐PET/CT as adjunctive diagnostic modalities in canine fever of unknown origin

Invited Review—image Registration in Veterinary Radiation Oncology: Indications, Implications, and Future Advances

Efeito do sorafenibe na carcinogênese hepática experimental secundária à doença hepática gordurosa não alcoólica

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¹⁸F‐FDG‐PET/CT as adjunctive diagnostic modalities in canine fever of unknown origin

¹⁸F‐FDG‐PET/CT as adjunctive diagnostic modalities in canine fever of unknown origin