PET [11C]acetate is also a perfusion tracer for kidney evaluation purposes

Normand, Gabrielle; Lemoine, Sandrine; Bars, Didier Le; Mérida, Inès; Irace, Zacharie; Troalen, Thomas; Costes, Nicolas; Juillard, Laurent

doi:10.1016/j.nucmedbio.2019.08.004

Cited by 13 publications

(9 citation statements)

References 8 publications

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“…A radiopharmaceutical is suitable for renal perfusion quantification if it shows high perfusion-rate-independent extraction from arterial blood in its first-pass transit through the renal capillaries [26]. The most commonly used PET tracer for perfusion measurement has been oxygen-15 radiolabeled water (H 2 15 O, radiowater) n = 15 [16,[27][28][29][30][31][32][33][34][35][36][37][38][39][40]. One study also reported that carbon-15 labeled acetate ( 11 C-acetate) can be used for the same purpose [37].…”

Section: Renal Perfusionmentioning

confidence: 99%

“…The most commonly used PET tracer for perfusion measurement has been oxygen-15 radiolabeled water (H 2 15 O, radiowater) n = 15 [16,[27][28][29][30][31][32][33][34][35][36][37][38][39][40]. One study also reported that carbon-15 labeled acetate ( 11 C-acetate) can be used for the same purpose [37]. A one-compartment model was used for the quantification of these tracers.…”

Section: Renal Perfusionmentioning

confidence: 99%

“…This was largely due to spillover from urine. Furthermore, 14(R, S)-[18F] fluoro-6-thia-heptadecanoate ( 18 F-FTHA) has been used to estimate cortical and medullar fatty acid uptake (n = 1) [38], while oxygen consumption has been quantified with 11 C-acetate n = 1 [37].…”

Section: Energy Substrate Metabolismmentioning

confidence: 99%

“…Three other PET tracers have also been shown to be usable in humans for the assessment of renal blood flow. Normand et al validated a modeling method for [ 11 C] acetate to measure perfusion, using radiowater as gold standard [37]. The benefit of the tracer is that it can also be used to measure oxidative metabolism and can thus provide information on two different functions [37].…”

Section: Renal Perfusionmentioning

confidence: 99%

“…Normand et al validated a modeling method for [ 11 C] acetate to measure perfusion, using radiowater as gold standard [37]. The benefit of the tracer is that it can also be used to measure oxidative metabolism and can thus provide information on two different functions [37]. 13 N-ammonia has also been validated for measuring perfusion [28], but has since not been utilized in kidney studies.…”

Section: Renal Perfusionmentioning

confidence: 99%

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The utilization of positron emission tomography in the evaluation of renal health and disease

Amoabeng

Laurila

Juárez-Orozco

et al. 2021

Clin Transl Imaging

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Purpose Positron emission tomography (PET) is a nuclear imaging technique that uses radiotracers to visualize metabolic processes of interest across different organs, to diagnose and manage diseases, and monitor therapeutic response. This systematic review aimed to characterize the value of PET for the assessment of renal metabolism and function in subjects with non-oncological metabolic disorders. Methods This review was conducted and reported in accordance with the PRISMA statement. Research articles reporting “kidney” or “renal” metabolism evaluated with PET imaging between 1980 and 2021 were systematically searched in Medline/PubMed, Science Direct, and the Cochrane Library. Search results were exported and stored in RefWorks, the duplicates were removed, and eligible studies were identified, evaluated, and summarized. Results Thirty reports met the inclusion criteria. The majority of the studies were prospective (73.33%, n = 22) in nature. The most utilized PET radiotracers were 15O-labeled radio water (H215O, n = 14) and 18F-fluorodeoxyglucose (18F-FDG, n = 8). Other radiotracers used in at least one study were 14(R,S)-(18)F-fluoro-6-thia-heptadecanoic acid (18F-FTHA), 18F-Sodium Fluoride (18F-NaF), 11C-acetate, 68-Gallium (68Ga), 13N-ammonia (13N-NH3), Rubidium-82 (82Rb), radiolabeled cationic ferritin (RadioCF), 11C‐para-aminobenzoic acid (11C-PABA), Gallium-68 pentixafor (68Ga-Pentixafor), 2-deoxy-2-F-fluoro-d-sorbitol (F-FDS) and 55Co-ethylene diamine tetra acetic acid (55Co-EDTA). Conclusion PET imaging provides an effective modality for evaluating a range of metabolic functions including glucose and fatty acid uptake, oxygen consumption and renal perfusion. Multiple positron emitting radiolabeled racers can be used for renal imaging in clinical settings. PET imaging thus holds the potential to improve the diagnosis of renal disorders, and to monitor disease progression and treatment response.

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Section: Renal Perfusionmentioning

confidence: 99%

Section: Renal Perfusionmentioning

confidence: 99%

Section: Energy Substrate Metabolismmentioning

confidence: 99%

Section: Renal Perfusionmentioning

confidence: 99%

Section: Renal Perfusionmentioning

confidence: 99%

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The utilization of positron emission tomography in the evaluation of renal health and disease

Amoabeng

Laurila

Juárez-Orozco

et al. 2021

Clin Transl Imaging

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Oxidation of hyperpolarized [1‐¹³C]pyruvate in isolated rat kidneys

et al. 2022

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Kidneys play a central role in numerous disorders but current imaging methods have limited utility to probe renal metabolism. Hyperpolarized (HP) 13C magnetic resonance imaging is uniquely suited to provide metabolite‐specific information about key biochemical pathways and it offers the further advantage that renal imaging is practical in humans. This study evaluated the feasibility of hyperpolarization examinations in a widely used model for analysis of renal physiology, the isolated kidney, which enables isolation of renal metabolism from the effects of other organs and validation of HP results by independent measurements. Isolated rat kidneys were supplied with either HP [1‐13C]pyruvate only or HP [1‐13C]pyruvate plus octanoate. Metabolic activity in both groups was confirmed by stable renal oxygen consumption. HP [1‐13C]pyruvate was readily metabolized to [13C]bicarbonate, [1‐13C]lactate, and [1‐13C]alanine, detectable seconds after HP [1‐13C]pyruvate was injected. Octanoate suppressed but did not eliminate the production of HP [13C]bicarbonate from [1‐13C]pyruvate. Steady‐state flux analyses using non‐HP 13C substrates validated the utilization of HP [1‐13C]pyruvate, as observed by HP 13C NMR. In the presence of octanoate, lactate is generated from a tricarboxylic acid cycle intermediate, oxaloacetate. The isolated rat kidney may serve as an excellent model for investigating and establishing new HP 13C metabolic probes for future kidney imaging applications.

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Physiological confounders of renal blood flow measurement

Alhummiany,

Sharma,

Buckley

et al. 2023

Magn Reson Mater Phy

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Objectives Renal blood flow (RBF) is controlled by a number of physiological factors that can contribute to the variability of its measurement. The purpose of this review is to assess the changes in RBF in response to a wide range of physiological confounders and derive practical recommendations on patient preparation and interpretation of RBF measurements with MRI. Methods A comprehensive search was conducted to include articles reporting on physiological variations of renal perfusion, blood and/or plasma flow in healthy humans. Results A total of 24 potential confounders were identified from the literature search and categorized into non-modifiable and modifiable factors. The non-modifiable factors include variables related to the demographics of a population (e.g. age, sex, and race) which cannot be manipulated but should be considered when interpreting RBF values between subjects. The modifiable factors include different activities (e.g. food/fluid intake, exercise training and medication use) that can be standardized in the study design. For each of the modifiable factors, evidence-based recommendations are provided to control for them in an RBF-measurement. Conclusion Future studies aiming to measure RBF are encouraged to follow a rigorous study design, that takes into account these recommendations for controlling the factors that can influence RBF results.

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PET [11C]acetate is also a perfusion tracer for kidney evaluation purposes

Cited by 13 publications

References 8 publications

The utilization of positron emission tomography in the evaluation of renal health and disease

The utilization of positron emission tomography in the evaluation of renal health and disease

Oxidation of hyperpolarized [1‐¹³C]pyruvate in isolated rat kidneys

Physiological confounders of renal blood flow measurement

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PET [11C]acetate is also a perfusion tracer for kidney evaluation purposes

Cited by 13 publications

References 8 publications

The utilization of positron emission tomography in the evaluation of renal health and disease

The utilization of positron emission tomography in the evaluation of renal health and disease

Oxidation of hyperpolarized [1‐13C]pyruvate in isolated rat kidneys

Physiological confounders of renal blood flow measurement

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Product

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Oxidation of hyperpolarized [1‐¹³C]pyruvate in isolated rat kidneys