“…The core is surrounded by an outer lipid bilayer envelope in which three envelope proteins E rns , E1, and E2 are inserted into the membrane ( Neill, 2013 ; Chi et al., 2022 ). The size of the BVDV genome ranges from 12.3 kilobases to 12.5 kilobases and consists of a single large open reading frame (ORF) flanked by short 5′- and 3′-untranslated regions (UTRs) ( Chi et al., 2022 ; Hong et al., 2023 ). The ORF encodes a single large polyprotein that is post-translationally cleaved into four structural proteins (C, E rns , E1, and E2) and eight non-structural proteins (N pro , p7, NS2, NS3, NS4A, NS4B, NS5A, and NS5B) ( Figure 1 ) ( Mirosław and Polak, 2019 ; King et al, 2021 ).…”