A copper-catalyzed
difunctional cyano-, thiocyano-, and chlorophosphorylation
reaction of alkynes with P(O)–H compounds and coupling partners
(TBACN, TMSNCS, TMSCl) is described. The reaction introduces versatile
groups (−P(O)R2 and −CN, −SCN, or
−Cl) to form tri- and tetrasubstituted alkenyl phosphine oxides/phosphonates
regio- and stereoselectively.