Pesticides, insecticides and male infertility

Roy, Priyanka; Phukan, Pranay; Changmai, Debojit; Boruah, Surajeet

doi:10.18203/2320-1770.ijrcog20173448

Cited by 7 publications

(2 citation statements)

References 10 publications

(8 reference statements)

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“…Moreover, pesticides can damage the male reproductive system by acting as EDCs. Indeed, the vast majority of pesticides are classified as EDCs [34]. Additionally, and as mentioned before, pesticides can act as obesogens, being 30 to 40% of all cases of male infertility closely associated with obesity [14,35].…”

Section: Effects and Mechanism Of Action Of Pesticides On Testicular Somatic Cellsmentioning

confidence: 93%

Pesticides and Male Fertility: A Dangerous Crosstalk

et al. 2021

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In recent decades, an increasing incidence of male infertility has been reported. Interestingly, and considering that pesticides have been used for a long time, the high incidence of this pathological state is concomitant with the increasing use of these chemicals, suggesting they are contributors for the development of human infertility. Data from literature highlight the ability of certain pesticides and/or their metabolites to persist in the environment for long periods of time, as well as to bioaccumulate in the food chain, thus contributing for their chronic exposure. Furthermore, pesticides can act as endocrine disrupting chemicals (EDCs), interfering with the normal function of natural hormones (which are responsible for the regulation of the reproductive system), or even as obesogens, promoting obesity and associated comorbidities, like infertility. Several in vitro and in vivo studies have focused on the effects and possible mechanisms of action of these pesticides on the male reproductive system that cause sundry negative effects, even though through diverse mechanisms, but all may lead to infertility. In this review, we present an up-to-date overview and discussion of the effects, and the metabolic and molecular features of pesticides on somatic cells and germinal tissues that affect germ cell differentiation.

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Section: Effects and Mechanism Of Action Of Pesticides On Testicular Somatic Cellsmentioning

confidence: 93%

Pesticides and Male Fertility: A Dangerous Crosstalk

et al. 2021

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“…Pesticides can also harm the male reproductive system by functioning as EDCs. Indeed, EDCs account for the great majority of pesticides [50]. Furthermore, as previously stated, pesticides can serve as obesogens, with 30 to 40% of all cases of male infertility strongly connected with obesity [51,52].…”

Section: Pesticide Chemicalsmentioning

confidence: 91%

Environmental contaminants and male infertility: a comprehensive review

Chhattar

2023

JFRH

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Environmental pollutants have become a topic of discussion in recent years due to their potential effects on male reproductive health. This review explores the connection between environmental pollutants and male infertility. Numerous studies have shown an alarming increase in male infertility rates across the globe and have associated environmental causes with infertility. It has been demonstrated that varied levels of male reproductive system dysfunctions are caused by pervasive pollutants, including pesticides, heavy metals, and endocrine-disrupting chemicals (EDCs). EDCs, such as bisphenol A (BPA) and phthalates, imitate or interfere with the way hormones work, altering sperm quality, sperm count, and sperm motility. Heavy metals like lead and cadmium build up in the body, impairing sperm production, while pesticides disturb hormonal balance and semen characteristics. This mini-review explores the ways through which environmental pollutants impair male fertility, identifying oxidative stress and epigenetic alterations as major factors. Strict regulations and lifestyle modifications are considered as possible tactics to lessen the effect of environmental pollutants on male infertility. In order to protect male reproductive health in a world that is becoming more contaminated, the need for additional study, public education, and legislative measures is underlined. Understanding these dynamics is essential for developing effective preventive measures and securing a healthier future for generations to come.

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