Pesticides induced oxidative stress in thymocytes

Olgun, Selen; Misra, Hara P.

doi:10.1007/s11010-006-9178-7

Cited by 44 publications

(21 citation statements)

References 40 publications

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“…), the hepatotoxicity induced by this chemical is mainly due to a potentiation of oxidative stress [44]. Another study performed on C57/BL6 mice confirmed that the toxicity of lindane in thymocytes is explained by an enhancement of O 2 -and hydrogen peroxyde [45]. These paradoxical effects could be explained by greater doses of lindane and chlordecone used by these authors.…”

Section: Discussionmentioning

confidence: 86%

Estrogen receptor alpha as a key target of organochlorines to promote angiogenesis

et al. 2012

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Epidemiological studies report that exposure to pesticides like chlordecone and lindane increases risk of cancer. They may act as endocrine disruptors via the activation of estrogen receptor α (ERα). Carcinogenesis involved angiogenesis and no available data regarding these organochlorines have been reported. The present study aimed at investigating the effects of lindane and chlordecone on cellular processes leading to angiogenesis through an involvement of ERα. Angiogenesis has been analyzed both in vitro, on human endothelial cells, and in vivo by quantifying neovascularization with the use of ECMgel® plug in mice. Both pesticides increased endothelial cell proliferation, migration and MMP2 activity. These toxics potentiated cell adhesion by enhancing FAK phosphorylation and stress fibers. The two organochlorines increased nitric oxide production via an enhancement of eNOS activity without modification of oxidative stress. Evidence has been provided that the two toxins increased in vivo neovascularization. Most interestingly, all the above processes were either partially or completely prevented after silencing of ERα. Altogether, these data highlight that organochlorines modulate cellular angiogenic processes through activation of ERα. This study further reinforces the harmful effects of these pesticides in carcinogenesis, particularly in the modulation of angiogenesis, a critical step in tumor promotion, through ERα.

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Section: Discussionmentioning

confidence: 86%

Estrogen receptor alpha as a key target of organochlorines to promote angiogenesis

et al. 2012

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“…de Liz Oliveira Cavalli [146] found that exposure to glyphosate causes oxidative stress and activates multiple stress-response pathways leading to Sertoli cell death in prepubertal rat testis. The role of oxidative stress in immune cell toxicity induced by the pesticides lindane, malathion, and permethrin was examined by Olgun and Misra [147]. Hassoun et al [148] reported that chlordane produces oxidative tissue damage based on the levels of hepatic lipid peroxidation and DNA damage (Table 3).…”

Section: Purposementioning

confidence: 99%

The Protective Role of Antioxidants in the Defence against ROS/RNS-Mediated Environmental Pollution

Poljšak

Fink

2014

Oxidative Medicine and Cellular Longevity

176

104

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Overproduction of reactive oxygen and nitrogen species can result from exposure to environmental pollutants, such as ionising and nonionising radiation, ultraviolet radiation, elevated concentrations of ozone, nitrogen oxides, sulphur dioxide, cigarette smoke, asbestos, particulate matter, pesticides, dioxins and furans, polycyclic aromatic hydrocarbons, and many other compounds present in the environment. It appears that increased oxidative/nitrosative stress is often neglected mechanism by which environmental pollutants affect human health. Oxidation of and oxidative damage to cellular components and biomolecules have been suggested to be involved in the aetiology of several chronic diseases, including cancer, cardiovascular disease, cataracts, age-related macular degeneration, and aging. Several studies have demonstrated that the human body can alleviate oxidative stress using exogenous antioxidants. However, not all dietary antioxidant supplements display protective effects, for example, β-carotene for lung cancer prevention in smokers or tocopherols for photooxidative stress. In this review, we explore the increases in oxidative stress caused by exposure to environmental pollutants and the protective effects of antioxidants.

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“…Rout and Shaw (2001) reported that SOD forms the first step in the removal of ROS; it rapidly removes O 2 -, and hence decreases the risk of the formation of OH from O 2 -. Esterase inhibition due to profenofos was also reported in larvae of Trichoplusiani ni and Bemisia tabaci (Olgun and Misra 2006). Lindane, Malathion, and Permethrin were known to increase total SOD activity in thymic cells from C57BL/6 rats (Panamangalore and Bebe 2000).…”

Section: Discussionmentioning

confidence: 79%

Biological detection and analysis of toxicity of organophosphate- and azadirachtin-based insecticides in Lathyrus sativus L.

et al. 2009

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In this study, attention was paid to investigate the effect of organophosphate insecticides, profenofos 40% EC, methyl parathion (metacid) 50% EC, and neem-based product nimbecidine 0.03% EC (from Azadirachta indica) on somatic chromosomal behavior, level of leaf protein, and activity of antioxidant enzymes in Lathyrus sativus L., the leguminous herb. The experiments on somatic chromosomes of root tip cells of L. sativus L. revealed that most common type of abnormalities were anaphase bridge, chromosome fragment, breaks, giant interphase, etc. Also, the mitotic index reduced and abnormality index enhanced, which were directly proportional to the rise in concentration as well as time period of exposure of chemicals. The profenofos and metacid induced drastic changes in mitotic index when compared with nimbecidine. The electrophoretic studies of leaf protein of L. sativus L. showed alteration of some major and minor protein bands subjected to spraying of organophosphate insecticides and induced to synthesize additional high molecular mass protein compared to untreated control. Analysis of SOD, EST, and POD activity by non-denaturing polyacrylamide gel electrophoresis showed different patterns of the isoforms. Complete inhibition of EST was observed in profenofos-treated plants, while with metacid- and nimbecidine-treated plants EST was suppressed. Induction and/or increased activities of SOD and POD were generally enhanced. Our present study not only provides the important information for better understanding of the toxic and tolerance mechanisms, but as well can be used as a bio-indicator for contamination by pesticides, which could cause genetic instabilities of natural plant populations and in crop varieties.

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Pesticides induced oxidative stress in thymocytes

Cited by 44 publications

References 40 publications

Estrogen receptor alpha as a key target of organochlorines to promote angiogenesis

Estrogen receptor alpha as a key target of organochlorines to promote angiogenesis

The Protective Role of Antioxidants in the Defence against ROS/RNS-Mediated Environmental Pollution

Biological detection and analysis of toxicity of organophosphate- and azadirachtin-based insecticides in Lathyrus sativus L.

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