Pesticides applied to crops and amyotrophic lateral sclerosis risk in the U.S

Andrew, Angeline S.; Zhou, Jie; Gui, Jiang; Harrison, Antoinette; Shi, Xun; Li, Meifang; Guetti, Bart; Nathan, Ramaa; Tischbein, Maeve; Pioro, Erik P.; Stommel, Elijah W.; Bradley, Walter G.

doi:10.1016/j.neuro.2021.09.004

Cited by 35 publications

(25 citation statements)

References 49 publications

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“…The Registry is the only federal program tasked to evaluate what may cause ALS and why and measuring the public health burden of this disease. Furthermore, the Registry also conducts and disseminates research findings internally and with its academic partners to identify new data gaps or potential links to newly identified biomarkers 12,13 …”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the Registry also conducts and disseminates research findings internally and with its academic partners to identify new data gaps or potential links to newly identified biomarkers. 12,13 Impact of the Registry-funded Research…”

Section: Discussionmentioning

confidence: 99%

“…Ultimately, the goal is for more in-depth research to further describe the role these risk factors play in the onset and progression of ALS. • Heavy metals: bioavailable methylmercury 22 • Heavy Metals: lead, 19,20,22 inorganic mercury 22,24 • Agricultural chemicals: MCPB (4-[2-methyl-4-chlorophenoxy]-butyric acid), Terbacil, glyphosate, paraquat, carbaryl, chlorpyrifos, Mancozeb (manganese-zinc ethylene-bis-di-thiocarbamate) 13 • Agricultural chemicals: 2,4-D (2,4dicholorophenoxyacetic acid), permethrin 13 • Water bodies: full-time residence within 2 miles of a water body, frequent water-related activities (water skiing, boating, sailing, kayaking) 20 • Trauma/injury: head trauma, severe electrical burn/electrocution 25 Metabolites or metabolic pathways…”

Section: Discussionmentioning

confidence: 99%

“…First, many of the publications identified by researchers have not been published long enough to be cited. Six additional publications identified during our search process have been published Subgroup analysis: insufficient sample sizes for specific subpopulations 20,22,23,30 • Larger cohort studies 22,23 • Targeted population sampling (e.g., exposure to water bodies, specific drug/therapeutic profiles, specific familial/genetic patterns, small-area populations, geographical "hot spots") 20,22,23,30 Latency analysis: insufficient detail on exposure timing and duration in reported information 13,20,22 • Additional information (e.g., prediagnostic exposures, residential history, weather-related exposure patterns, distance to chemical use) 13 • Biological specimen (estimates for exposure dose, bioaccumulation) 13,20 • Prospective cohort studies 13,22 Confounding: challenges related to identifying ideal population-based control cohorts 19 • Standardized methodologies for control recruitment (e.g., sibling controls, matched population controls) 9,19 • Prospective cohort studies 19 Causal inference: unclear cause-effect relationship between observed exposures and disease outcomes 20,22,24,30 • Prospective cohort studies 22 • Experimental studies for identified risk factors 22 • Mechanistic studies for less-studied chemicals 13 Clinic-based ALS cohorts (e.g., hospital, multicenter)…”

Section: Limitationsmentioning

confidence: 99%

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Impact of the National Amyotrophic Lateral Sclerosis Registry: Analysis of Registry‐funded Research

Rechtman

Brenner

Wright

et al. 2022

Ann Clin Transl Neurol

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Objective: This research aims to examine the impact of the National Amyotrophic Lateral Sclerosis (ALS) Registry-funded research activities. Methods: Registry-funded research and related publications were identified through the National ALS Registry website, the National Institutes of Health (NIH) Reporter website, and verified by Principal Investigators. Key study characteristics (e.g., study population, sample size) and key impact features (e.g., risk factors) were abstracted and recorded on study abstraction forms. Descriptive statistics were used to analyze the volume, productivity, and findings of the Registryfunded research. Results: Since 2012, the National ALS Registry funded 21 research projects. Of these, 14 were through extramural research grants and included in the analysis. These studies are often related to environmental, medical conditions, and genetic risk factors. On average, the funded grants produced 1 to 2 publications which were cited 114 times by other researchers. The relative citation ratio averaged 1.81 with a weighted relative citation ratio of 16.28. These studies supported the identification and confirmation of candidate risk factors. Environmental and occupational risk factors typically related to heavy metal exposure (e.g., lead, mercury) and agricultural chemicals (e.g., pesticides, herbicides), and the occupations associated with exposure to these substances were most frequently explored. Interpretation: The National ALS Registry is a multifaceted research platform, one component of which is funded research. This Registry-funded research fills an essential gap in the overall ALS scientific community as it is difficult to prevent and treat a disease without a deeper understanding of its causes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

See 2 more Smart Citations

Impact of the National Amyotrophic Lateral Sclerosis Registry: Analysis of Registry‐funded Research

Rechtman

Brenner

Wright

et al. 2022

Ann Clin Transl Neurol

View full text Add to dashboard Cite

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“…There is currently neither cure nor treatments to slow or reverse its progression. It is influenced by environmental and genetic factors, although the exact mechanisms of these remains unknown, epigenetic alteration may be crucially involved ( 79 – 81 ). RBP gene mutations have been associated with neurodegenerative and psychiatric diseases, suggesting that RBP may be a cause of ALS ( 82 , 83 ).…”

Section: A Methyltransferase Complexmentioning

confidence: 99%

m6A RNA methylation in brain injury and neurodegenerative disease

Deng

Chen

et al. 2022

Front. Neurol.

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N6-methyladenosine (m6A), the most prevalent post-transcriptional RNA modification throughout the eukaryotic transcriptome, participates in diverse biophysiological processes including cell fates, embryonic development and stress responses. Accumulating evidence suggests that m6A modification in neural development and differentiation are highly regulated processes. As RNA m6A is crucial to protein translation and various bioprocesses, its modification dysregulation may also be associated with brain injury. This review highlights the biological significance of m6A modification in neurodegenerative disease and brain injury, including cerebrovascular disorders, is highlighted. Emphasis is placed on recent findings that elucidate the relevant molecular functional mechanism of m6A modification after brain injury and neurodegenerative disease. Finally, a neurobiological basis for further investigation of potential treatments is described.

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Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions

Sakowski,

Koubek,

Chen

et al. 2024

Annals of Neurology

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Neurodegenerative diseases are increasing in prevalence and place a significant burden on society. The causes are multifactorial and complex, and increasing evidence suggests a dynamic interplay between genes and the environment, emphasizing the importance of identifying and understanding the role of lifelong exposures, known as the exposome, on the nervous system. This review provides an overview of recent advances toward defining neurodegenerative disease exposomes, focusing on Parkinson's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. We present the current state of the field based on emerging data, elaborate on key themes and potential mechanisms, and conclude with limitations and future directions. ANN NEUROL 2024

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Pesticides applied to crops and amyotrophic lateral sclerosis risk in the U.S

Cited by 35 publications

References 49 publications

Impact of the National Amyotrophic Lateral Sclerosis Registry: Analysis of Registry‐funded Research

Impact of the National Amyotrophic Lateral Sclerosis Registry: Analysis of Registry‐funded Research

m6A RNA methylation in brain injury and neurodegenerative disease

Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions

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