Pesticides and Hepatotoxicity

Hodgson, Ernest; Meyer, Sharon A.

doi:10.1016/b978-0-08-046884-6.01021-6

Cited by 5 publications

(2 citation statements)

References 268 publications

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“…These examples are drawn from studies conducted in the authors’ laboratory at North Carolina State University. A more complete set of citations may be found in …”

Section: Studies Of Metabolism and Metabolic Interactionsmentioning

confidence: 99%

Human Variation and Risk Assessment: Microarray and Other Studies Utilizing Human Hepatocytes and Human Liver Subcellular Preparations

Hodgson

Wallace

Shah

et al. 2013

J Biochem & Molecular Tox

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The new paradigms proposed for human health risk assessment stress the need for the use of human and human-derived cell lines, and this review summarizes the use of primary human hepatocytes and hepatocyte subcellular preparations for the investigation of the metabolism and metabolic interactions of environmental chemicals. This includes interactions based on inhibition, induction, and activation. The role of cytotoxicity is also considered. The use of hepatocytes and hepatocyte preparations provides especially important information for the investigation of human variation and is summarized. This area is, at present, relatively neglected but will in the future be essential for accurate assessment of human health risk. A detailed summary of an initial attempt to utilize microarray technology for the study of genome-wide effects is included.

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“…These examples are drawn from studies conducted in the authors’ laboratory at North Carolina State University. A more complete set of citations may be found in …”

Section: Studies Of Metabolism and Metabolic Interactionsmentioning

confidence: 99%

Human Variation and Risk Assessment: Microarray and Other Studies Utilizing Human Hepatocytes and Human Liver Subcellular Preparations

Hodgson

Wallace

Shah

et al. 2013

J Biochem & Molecular Tox

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“…It has four lobes consisting of 50,000 to 100,000 individual hepatic lobules [3]. According to [4], the liver, the largest organ in the body, is often the target organ for chemically induced injuries. There are a number of reasons why the liver is particularly susceptible.…”

Section: Introductionmentioning

confidence: 99%

Exposure to uppercott induces hepatotoxicity in male albino wistar rats

et al. 2017

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Background: The use of herbicides and pesticides in agriculture and for public health purposes has led to harmful effects in many nontarget species including man. Methods: In this study, the hepatic effect of exposure to cypermethrin and dimethoate mixture (uppercott) was investigated in male albino wistar rats. Forty five (45) male wistar albino rats were distributed into five (5) groups of nine (9) animals each. Groups 1 and 2 served as the normal control and oil control respectively, groups 3, 4 and 5 received 2.5%, 5% and 7.5% LD50 of uppercott orally for 28 days. Results: Results obtained revealed that uppercott exposure significantly (p<0.05) increased serum aspartate aminotransferase (AST) activity, alanine aminotransferase (ALT) activity and alkaline phosphatase (ALP) activity when the test groups were compared with control. Also, uppercott exposure raised serum bilirubin concentration slightly insignificantly compared to the control. Superoxide dismutase activity was significantly reduced across all test groups as compared with compared with control. Histology of liver tissues revealed patchy necrotic sessions in the liver tissues of the test experimental groups (2.5%, 5% and 7.5%). Conclusion:The results obtained from this study are strongly indicative of the hepatotoxic effect of uppercott pesticide and hence, caution during usage is advised.

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Metabolism and Hepatotoxicity of Pesticides

Hodgson

Meyer²

2018

Comprehensive Toxicology

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Pesticides and Hepatotoxicity

Cited by 5 publications

References 268 publications

Human Variation and Risk Assessment: Microarray and Other Studies Utilizing Human Hepatocytes and Human Liver Subcellular Preparations

Human Variation and Risk Assessment: Microarray and Other Studies Utilizing Human Hepatocytes and Human Liver Subcellular Preparations

Exposure to uppercott induces hepatotoxicity in male albino wistar rats

Metabolism and Hepatotoxicity of Pesticides

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