Pesticides and cancer: Insights into toxicoproteomic-based findings

George, Jasmine; Shukla, Yogeshwer

doi:10.1016/j.jprot.2011.09.024

Cited by 100 publications

(47 citation statements)

References 84 publications

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“…Organochlorines, organophosphorates, carbamates, and pyrethroids are extensively used among others [63,64]. Pesticides are linked to neuro-and hypato-toxicity, reproductive disorders, disruption of hormonal and enzymatic regulation, several types of cancer and other chronic diseases [65,66]. They may burden consumers mainly through the consumption of fresh, raw and unprocessed conventionally cultivated vegetables and fruits.…”

Section: Pesticide Residues Dietary Intake Preventionmentioning

confidence: 99%

Preventive Practices from Field and Shelf to Fork to Minimize Chemical Hazards Dietary Intake

2016

J Nutr Health

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Chronic diseases such as cancer, neurodegenerative disorders, cardiovascular and autoimmune diseases have been related with food chemical hazards intake. Therefore, great concern of food manufacturers and authorities is to ensure food safety and quality and minimize exposure to relevant risks. Nevertheless, the latter cannot be totally eliminated, when by employing erroneous treatments extra risks are added. Public awareness and relevant knowledge among food professionals and food handlers is lacking, even on countries that possess advanced food safety systems and strict food legislation. Besides, financial difficulty reinforces people to utilize low quality food and houseware increasing the health related hazards. Regarding the severity for global health and damage costs, the need for information on precautionary practices that will reduce chemical hazards dietary intake is imperative. In the present review certain practices such as thermal processing, washing or appropriate handling of the raw material are listed to educate anyone related with the food sector how to minimize heavy metals, acrylamide, pesticides residues, heterocyclic aromatic amines and polycyclic aromatic hydrocarbons intake and promote health. The introduced simple practices can be applied except for home kitchens, also in quality systems of professional kitchens, warehouses and food industries.

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Section: Pesticide Residues Dietary Intake Preventionmentioning

confidence: 99%

Preventive Practices from Field and Shelf to Fork to Minimize Chemical Hazards Dietary Intake

2016

J Nutr Health

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“…One well-known example is the case of Paraquat associated to the onset of the Parkinson's disease which also proved to be lethal for human embryos (Snyder and D'Amato 1985). In addition to the problems of acute toxicity, the chronic exposure to some products displays a recognized risk for cancerogenicity (George and Shukla 2011) for which the enforced norms demand for ecotoxicological monitoring and usage modalities associated to environmental dynamics and persistence of the different products. Another typical example of toxicity for human is the case of methyl bromide widely used as fumigant for the control of pathogens in the soil, among which nematodes which was reported to produce acute respiratory problems and long term neurological damages (Anger et al 1986;Deschamps and Turpin 1996).…”

Section: Problems In Traditional Pharmacological Researchmentioning

confidence: 99%

New perspectives on the use of nucleic acids in pharmacological applications: inhibitory action of extracellular self-DNA in biological systems

et al. 2014

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Bioactive natural compounds from garlic and onions have been the focus of researches for decades, firstly due to their pharmacological effects, and secondly due to their defence properties against plant diseases. In fact, garlic and onion, belonging to Allium genus, are among the oldest food plants known since ancient times and used as ingredient of many recipes and for therapeutic properties. These plants are well known to produce bioactive apolar sulphur compounds but less is known about their polar natural compounds, such as phenols, sapogenins and saponins, that are more stable to cooking, So, we continued our work on the discovery of polar bioactive metabolites from Allium with the isolation of a number of sapogenins and saponins from the wild onion species Allium elburzense, Allium hirtifolium, Allium atroviolaceum, and Allium minutiflorum, and, more recently, from the cultivated white onion, Allium cepa, and garlic, Allium sativum. In particular, the sapogenins and saponins isolated from A. elburzense and A. hirtifolium, named elburzensosides and hirtifoliosides respectively, exhibited significant antispasmodic properties. In addition, the saponins named minutosides isolated from A. minutiflorum showed promising antimicrobial activity. More recently the phytochemical analysis of A. cepa and A. sativum has been undertaken and afforded the characterization of saponins, phenols and N-cynnamic amides which showed significant antifungal activit

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“…They are used in agriculture to increasing productivity. Some pesticides are highly toxic, non bio-degradable and persist in the environment for a very long period of time (George et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Determination of Selected Pesticide Residues in River Water Using SBSE Technique

Purdešová

2017

Acta Univ. Agric. Silvic. Mendelianae Brun.

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The analytical procedure based on stir-bar sorptive extraction technique, for the determination of selected pesticide residues (diazinon, malathion, cyprodinyl, penconazole, fludioxonyl, pyriproxyfen, boscalid, pyraclostrobin) is described. Analysis was performed using the commercial Twister TM stir bar for sorptive extraction. It consists of a 2.0-cm-long glass-encapsulated magnetic stir bar externally coated with PDMS. The extracts were off-line analyzed using fast GC-MS in SIM mode. Optimized conditions were established as follows concerning extraction time, stirring speed, aqueous medium characteristics (ionic strength and polarity) respectively: 120 min (700 rpm), addition of 4 g of sodium chloride, no addition of methanol as organic modifier, and 30 min ultrasonic desorption in acetonitrile. Recoveries ranged from 38 % to 58 % (RSD < 15 %, n = 6). Validated limits of quantification in matrix were between 1.6 ngL −1 and 548.8 ngL −1 , depending on the compound.

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Pesticides and cancer: Insights into toxicoproteomic-based findings

Cited by 100 publications

References 84 publications

Preventive Practices from Field and Shelf to Fork to Minimize Chemical Hazards Dietary Intake

Preventive Practices from Field and Shelf to Fork to Minimize Chemical Hazards Dietary Intake

New perspectives on the use of nucleic acids in pharmacological applications: inhibitory action of extracellular self-DNA in biological systems

Determination of Selected Pesticide Residues in River Water Using SBSE Technique

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