Pesticide Use, Poisoning, and Knowledge and Unsafe Occupational Practices in Thailand

Sapbamrer, Ratana

doi:10.1177/1048291118759311

Cited by 49 publications

(43 citation statements)

References 38 publications

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“…In this concept, carbofuran has been identified as a hazardous compound for the humans causing severe poisoning and death (Ameno et al, 2001; Rajbanshi, 2017). Some recent reports confirmed the presence of carbofuran in honey samples, apples collected from Almaty Region of Kazakhstan, and watermelon in Thailand (El‐Nahhal, 2020; Łozowicka et al, 2020; Sapbamrer, 2018). Beyond the human toxicity, carbofuran also poses an enormous threat to the inhabitants of different ecosystems including birds, honeybees, fishes, and other aquatic species (Amaeze et al, 2020; Mishra et al, 2020).…”

Section: Introductionmentioning

confidence: 83%

Carbofuran cytotoxicity, DNA damage, oxidative stress, and cell death in human umbilical vein endothelial cells: Evidence of vascular toxicity

Saquib

Siddiqui

Ansari

et al. 2021

J of Applied Toxicology

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Carbofuran is a broad‐spectrum carbamate insecticide, which principally inhibits the acetylcholinesterase (AChE) enzyme in the nervous system. Nonetheless, their selective action is not restricted to a single species and expanded to humans. No studies are available on the toxicological effects of carbofuran in the endothelial cells (ECs), which first confronts the toxicants in blood vessels. Hence, we have exposed the human umbilical vein ECs (HUVECs) with carbofuran for 24 h, which significantly reduced the cell survival to 25.16% and 33.48% at 500 and 1,000 μM analyzed by MTT assay. In the neutral red uptake (NRU) assay, 16.68%, 30.99%, and 58.11% survival decline was found at 250, 500, and 1,000 μM of carbofuran. HUVECs exposed to carbofuran showed significant increase in the intracellular reactive oxygen species (ROS), indicating oxidative stress at low concentrations. In parallel, HUVECs showed hyperpolarization effects in the mitochondrial membrane potential (ΔΨm) upon carbofuran exposure. Carbofuran induced DNA damage in HUVECs measured as 8.80, 11.82, 35.56, and 79.69 Olive tail moment (OTM) in 100‐, 250‐, 500‐, and 1,000‐μM exposure groups. Flow cytometric analysis showed apoptotic peak (SubG1) and G2M arrest in the HUVECs exposed to carbofuran. Overall, our novel data confirm that carbofuran is toxic for the EC cells, especially at the higher concentrations, which may affect the vascular functions and possibly angiogenesis. Hence, carbofuran should be applied judiciously, and detailed vascular studies are warranted to gain an in‐depth information focusing the transcriptomic and translation changes employing suitable in vivo and in vitro test models.

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Section: Introductionmentioning

confidence: 83%

Carbofuran cytotoxicity, DNA damage, oxidative stress, and cell death in human umbilical vein endothelial cells: Evidence of vascular toxicity

Saquib

Siddiqui

Ansari

et al. 2021

J of Applied Toxicology

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“…Pesticide poisoning has been identified as a significant public health problem [15]. The major reason for its occurrence includes cases of occupational, accidental, and intentional poisoning [16,17,18,19]. Until now, pesticides are utilized on a vast scale globally, including in China [20].…”

Section: Discussionmentioning

confidence: 99%

Types of Exposure Pesticide Poisoning in Jiangsu Province, China; The Epidemiologic Trend between 2006 and 2018

Wang

Wen³

et al. 2019

IJERPH

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Background: Pesticide poisoning is an important issue in rural China, and is also a major public health problem that affects the health of farmers. The purpose of this paper is to explore the epidemiology of pesticide poisoning in Jiangsu Province, and to put forward the relevant suggestions on the logical and discerning utilization of the pesticides. Methods: According to the data of the pesticide poisoning report card established by the health hazard detection information system, the cases of pesticide poisoning in Jiangsu Province from 2006 to 2018 were exported to Excel, and the database of pesticide poisoning was established. Furthermore, the imported data was screened and collected. A descriptive statistical analysis had been employed on this data utilizing SPSS 20.0. Results: Between the years 2006 and 2018, 38,513 pesticide poisoning cases were registered in Jiangsu Province, with a downward trend. Meanwhile, 77.83% of poisoning cases involved insecticide poisoning, followed by herbicide and rodenticide. The greater part of the diverse sorts of studied insecticide poisoning cases involved people aged between 30 and 59 years (57.51%). Poisoning cases caused by rodenticide accounted for a large proportion of people aged between 0 and 14 years (23.72%) in non-occupational pesticide poisoning. Regarding seasons, it was distinguished that more insecticide cases were reported in autumn (46.95% of the total number of cases). Pesticide poisoning was reported in 13 cities of Jiangsu Province, and among these, insecticide poisoning was reported mainly from the northern Jiangsu area, which was the same as rodenticide and herbicide. Conclusions: Although there is a decreased risk for pesticide poisoning among farmworkers in Jiangsu Province, the number of farmworkers with pesticide poisoning is still high. Further management of the pesticide utilization is necessary, especially insecticide. More attention ought to be paid to the protection of vulnerable groups, including children and the elderly.

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“…Although remarkably successful, extensive pesticide usage gave birth to new problems, the most important one of which were environmental toxicity, and bioaccumulation [21–25]. Extensive and random usage, for example, inadequate application and spraying equipment and poor storage techniques resulted in soil, water, and food contamination that threatened public health and nontarget organisms [26–30]. Groundwater contamination by the leaching of agricultural pesticides from soils is a serious problem leading to pollution of the aquatic environment [24,31,32].…”

Section: Dilemma Of Using Pesticidesmentioning

confidence: 99%

“…Increased reactive oxygen species (ROS) levels as a result of pesticide usage and exposure can be associated with imbalances in cell homeostasis, which, in turn, affects cellular components and DNA stability, and causes genotoxicity [42,44–50]. A positive correlation between the incidence of various types of cancers such as leukemia, lung, and ovarian cancer as dependent variable and exposure to pesticides has been shown in many studies [13,29,30]. Besides the serious environmental and public health issues, different pest species have developed resistance to these chemicals, which leads to significant reduction in their effectiveness.…”

Section: Dilemma Of Using Pesticidesmentioning

confidence: 99%

Are insect GPCRs ideal next‐generation pesticides: opportunities and challenges

et al. 2021

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The increasing human population, combined with low inefficiency and adverse effects of available pesticides, has magnified the urgent need of developing next-generation pesticides. Among the available approaches, strategies targeting invertebrate G protein-coupled receptors (GPCRs) are very promising as these receptors are the targets of endogenous neuropeptides/neuromodulators that upon binding to their receptors induce profound changes in insect physiology. Therefore, exploring GPCR regulators has great potential in the development of targeted next-generation pesticides. Despite the great potential of such alternative pesticides, so far there has been only one approved compound, Amitraz, which conveys its antipest activity via the GPCR Octopamine receptor. Here, we review the current status of pesticide development, hazards associated with conventional pesticide compounds, alternative strategies that involve next-generation of pesticides, structural features of GPCRs, and opportunities and challenges of targeting the members of this superfamily in invertebrates to develop anti-pest agents. In conclusion, we emphasize that the potential of GPCRs cannot be utilized in full without more genomic and transcriptomic data to improve our understanding of the complex network of peptidergic signaling pathways. We argue how vital it is to obtain three-dimensional (3D) structural data on physiologically important target GPCRs and encourage the readers to use the state of the art in silico methods such as virtual screening for the discovery of new pesticide compounds.

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Pesticide Use, Poisoning, and Knowledge and Unsafe Occupational Practices in Thailand

Cited by 49 publications

References 38 publications

Carbofuran cytotoxicity, DNA damage, oxidative stress, and cell death in human umbilical vein endothelial cells: Evidence of vascular toxicity

Carbofuran cytotoxicity, DNA damage, oxidative stress, and cell death in human umbilical vein endothelial cells: Evidence of vascular toxicity

Types of Exposure Pesticide Poisoning in Jiangsu Province, China; The Epidemiologic Trend between 2006 and 2018

Are insect GPCRs ideal next‐generation pesticides: opportunities and challenges

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