Pesticide use in agriculture and Parkinson’s disease in the AGRICAN cohort study

Pouchieu, Camille; Piel, Clément; Carles, Camille; Gruber, A.; Helmer, Catherine; Tual, Séverine; Marcotullio, Elisabeth; Lebailly, Pierre; Baldi, Isabelle

doi:10.1093/ije/dyx225

Cited by 108 publications

(66 citation statements)

References 27 publications

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“…While this relationship has been previously assessed in crop farmers, the identification of animal farmers as a population at risk due to shared exposures is a notable contribution of work from this year. Pouchieu and colleagues evaluated the risk of PD among both livestock and crop farmers in France exposed to pesticides in the AGRICAN cohort [60]. The crop matrix PESTIMAT was used to evaluate exposure to active ingredients and duration of lifelong use, and the implementation of this matrix again reinforces the interest in evaluating complex and realistic mixture scenarios for worker exposures.…”

Section: Pesticides and Chemical Exposurementioning

confidence: 99%

Recent Research on Occupational Animal Exposures and Health Risks: A Narrative Review

Dignard

Leibler

2019

Curr Envir Health Rpt

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Section: Pesticides and Chemical Exposurementioning

confidence: 99%

Recent Research on Occupational Animal Exposures and Health Risks: A Narrative Review

Dignard

Leibler

2019

Curr Envir Health Rpt

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“…Familial form accounts for ~ 10 -15 % of all PD cases and is associated with seven causal genes including alpha-synuclein (SNCA), leucine-rich repeat Kinase 2 (LRRK2), glucocerebrosidase (GBA), vacuolar protein sortingassociated protein 35 (VPS35), parkin RBR E3 ubiquitin protein ligase (PARK2),phosphatase and tensing homologinduced Kinase 1 (PINK1), and Parkinson protein 7 (PARK7) (Verstraeten et al, 2015;Kalinderi et al, 2016). Sporadic PD affects ~ 85 -90 % of the cases and is believed to return to environmental exposures, most notably, chemicals, pesticides and heavy metals (Castillo et al, 2017;Pouchieu et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Autophagy Inhibitor 3-Methyladenine could not Modulate Rotenone Neurotoxicity in Primary Mesencephalic Cell Culture

et al. 2020

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Dysregulated autophagy, whether excessive or downregulated, has been thought to be associated with neurodegenerative disorders including Parkinson's disease. Accordingly, the present study was carried out to investigate whether 3-methyladenine, an autophagy inhibitor, can modulate the effects of rotenone on dopaminergic neurons in primary mesencephalic cell culture. Cultures were prepared from embryonic mouse mesencephala at gestation day 14. Four groups of cultures were treated on the 10th DIV for 48 h as follows: the first was kept as an untreated control, the second was treated with 3-methyladenine alone (1, 10, 100, 200 mM), the third was treated with 20 nM rotenone and the fourth was co-treated with 20 nM rotenone and 3-methyladenine (1, 10, 100, 200 mM). On the 12th DIV, cultured cells were stained immunohistochemically against tyrosine hydroxylase and culture media were used to measure the levels of lactate dehydrogenase. 3methyladenine had no effects on both the survival of dopaminergic neurons and the release of lactate dehydrogenase. Rotenone significantly decreased the number of dopaminergic neurons and increased the levels of lactate dehydrogenase in the culture media. When cultures concomitantly treated with 3-methyladenine and rotenone, 3-methyladenine had no effect against rotenone-induced dopaminergic cell damage and lactate dehydrogenase release into the culture medium. In conclusion, the autophagy inhibitor 3-methyladenine could not modulate rotenone-induced dopaminergic cell damage in primary mesencephalic cell culture.

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“…Soon after, other toxins such as rotenone and organophosphates were investigated with epidemiological evidence suggesting a higher risk of developing PD [2]. More recently, occupational exposure to a variety of pesticides including herbicides, insecticides, and fungicides were associated with the development of PD in France [3]. In addition to preferentially damaging dopaminergic neurons, these agents share several common mechanisms of action including increasing neuronal oxidating stress, damaging mitochondrial complex I, and impairing the ubiquitin-proteasome system [4,5].…”

Section: Introductionmentioning

confidence: 99%

Occupational pesticide exposure and the risk of death in patients with Parkinson’s disease: an observational study in Southern Brazil.

Medeiros

Reddy

Socal

et al. 2020

Preprint

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Background Multiple studies have suggested that various pesticides are associated with a higher risk of developing Parkinson’s disease (PD) and may influence the progression of the disease. This study examines whether pesticide exposure influences the risk of mortality among patients with PD in Southern Brazil, when accounting for socioeconomic status, nicotine exposure, and caffeine exposure. Methods 150 patients with idiopathic PD were enrolled from 2008-2013 and followed until 2019. In addition to undergoing a detailed neurologic evaluation, patients completed surveys regarding socioeconomic status and environmental exposures. Results Twenty patients (13.3%) reported a history of occupational pesticide exposure with a median duration of exposure of 10 years (mean = 13.1, SD = 11.2). Patients with a history of occupational pesticide exposure had higher UPDRS-III scores, though there were no significant differences in regards to age, sex, disease duration, Charlson Comorbidity Index, and age at symptom onset. Patients with occupational pesticide exposure were more than twice as likely to die than their unexposed PD counterparts (HR = 2.32, 95% CI [1.15, 4.66], p = 0.22). Occupational pesticide exposure was also a significant predictor of death in a cox-proportional hazards model which included smoking and caffeine intake history and another which included several measures of socioeconomic status. Conclusion In this prospective cohort study, we found an increased all-cause mortality risk in PD patients with occupational exposure to pesticides. More studies are needed to further analyze this topic with longer follow-up periods, more detailed exposure information, and more specific causes of mortality.

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Pesticide use in agriculture and Parkinson’s disease in the AGRICAN cohort study

Abstract: Our work suggests that the risk of PD is increased in farmers exposed to pesticides on several French crops and livestock, and supports additional evidence of an association of PD with dithiocarbamate fungicides, rotenone and the herbicides diquat and paraquat.

Cited by 108 publications

References 27 publications

Recent Research on Occupational Animal Exposures and Health Risks: A Narrative Review

Recent Research on Occupational Animal Exposures and Health Risks: A Narrative Review

Autophagy Inhibitor 3-Methyladenine could not Modulate Rotenone Neurotoxicity in Primary Mesencephalic Cell Culture

Occupational pesticide exposure and the risk of death in patients with Parkinson’s disease: an observational study in Southern Brazil.

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