Pesticide Residues in Natural Products with Pharmaceutical Use: Occurrence, Analytical Advances and Perspectives

Pérez-Parada, Andrés; Colazzo, Marcos; Besil, Natalia; Dellacassa, Eduardo; Cesio, Verónica; Heinzen, Horacio; Fernández‐Alba, Amadeo R.

doi:10.5772/16489

Cited by 11 publications

(8 citation statements)

References 95 publications

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“…QuEChERS involves liquid extraction with acetonitrile, and NaCl, MgSO 4 , and buffering salts, for phase separation and pH adjustment, to obtain a raw extract, and then a solid‐phase extraction step, often using dispersive solid‐phase extraction, by mixing it with MgSO 4 and a sorbent to remove water and unwanted co‐extracted compounds. The final extract can be analysed directly by GC and/or LC techniques . As EOs share physicochemical similarities with pesticides, matrix effects can also be significantly eliminated by evaporation and re‐solvation, or by diluting the EO sample, as described in some papers.…”

Section: Pesticide Analysis In Essential Oilsmentioning

confidence: 99%

“…Studies indicate that pesticides are influencing bee behaviour, and reduce locomotion and time spent at a food source, limit movement towards light, and increase worker mortality . The global use of herbal medicines such as EOs continues to rise, and EOs have become commercially available in the form of many ‘over the counter’ products in recent years . Therefore, any pesticide residues, and also biological contaminants, heavy metals, or mycotoxins, that EOs may contain come in direct contact with the end consumer, and this raises questions about the quality and safety of Eos…”

Section: Introductionmentioning

confidence: 99%

“…For most commercially used EOs, like anise, peppermint, eucalyptus, or citrus oil, the average yields do not usually exceed 5%, however . Although relatively small quantities of EOs are extracted from medicinal herbs, the fact that both EOs and pesticides are lipophilic in nature indicates that the transfer of pesticides into the oil during the distillation process is possible . The successful detection and quantification of pesticides and their residues depends upon various factors.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pesticides in essential oils and selected fragrance extracts. Some examples. A review

Nikolić

Höferl

Buchbauer

2018

Flavour & Fragrance J

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The use of essential oils (EOs) worldwide continues to rise, and EOs are already established in folk and western medicine as remedies against inflammation, respiratory diseases, and infections, and are used for aromatherapy, insect repellents, food preservatives, and in the perfume and cosmetics industries. Pesticide residues are already present in the environment, however, and are thus also found in the aromatic plants used for EO production. The control of pesticides in EOs is therefore essential, especially with the recent trends in EO consumption. This paper is an overview on possible methods used for the determination of pesticide residues in EOs, covering the work of the scientific community in the last 20–25 years.

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Section: Pesticide Analysis In Essential Oilsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pesticides in essential oils and selected fragrance extracts. Some examples. A review

Nikolić

Höferl

Buchbauer

2018

Flavour & Fragrance J

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“…With the rapid development of the modern pharmaceutical industry, the study of pesticides and medicines with high efficiency and low toxicity have become a widespread concern of scholars at home and abroad [1–3]. At present, quantitative structure‐activity relationship (QSAR) has been widely used in fields such as medicinal chemistry, that is, changes in activity always correspond to changes in main structural factors [4,5].…”

Section: Introductionmentioning

confidence: 99%

Activity prediction of aminoquinoline drugs based on deep learning

Wang

Chen

Zhu

et al. 2020

Biotech and App Biochem

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The results of the traditional prediction method for the activity of aminoquinoline drugs are inaccurate, so the prediction method for the activity of aminoquinoline drugs based on the deep learning is designed. The molecular holographic distance vector method was used to describe the molecular structure of 40 aminoquinoline compounds, and the principal component regression method was used for modeling and quantitative analysis. Two methods were used to predict the activity of aminoquinoline drugs. The correlation coefficients of the results obtained from the two sets of activity data and the cross test were 0.9438 and 0.9737, and 0.8305 and 0.9098, respectively. Our data suggested that method for the activity prediction of aminoquinoline drugs based on deep learning studied in this paper can better predict the activity of aminoquinoline drugs and provide a strong basis for the activity prediction of aminoquinoline drugs.

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“…A review of the presence and evolution of pesticides and plasticizers in Italian essential oils according the type of citrus EO was published by Saitta and his group in 2012 [31]. The developed sample preparations for EOs are diverse; from solid/liquid extraction either using cartridge based SPE or Matrix Solid Dispersion (MSPD) [28,32] o a sample dilution step after oil evaporation as applied by Fillatre et al [33].…”

Section: Introductionmentioning

confidence: 99%

Analytical methods for the routinely evaluation of pesticide residues in lemon fruits and by products

et al. 2019

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Citrus fruits and their by-products such as concentrated juices and essential oils are important intermediate by-products in the food industry that can selectively accumulate plant protection agrochemicals employed in their production. They are very difficult matrices for pesticide residue analysis due their high number and concentration of phytochemicals that could hamper the determinations. The fruit processing leads to the concentration/dilution or elimination of some of these natural products that change totally the nature of the matrix where the pesticides partition unevenly. Looking at the industrial process of the fruit, a unified vision for the pesticide residues analysis throughout the lemon fruit chain production, useful for the routine analysis of the above mentioned three matrices is presented. The driven concept is the minimization of matrix effects through sample dilution of the concentrated by-products, either after sample treatment or not. This approach will contribute to the maintenance of the whole instrumental system. QuEChERS AOAC 2007.01 was selected as the most suitable protocol for routine determination of, residues of 16 the pesticides most commonly used in the fruits during the citrus production through liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The same protocol was applied for pesticide residue analysis in concentrated juice after diluting 4 times the sample to minimize the matrix effects. For the analysis of lemon essential oils, the dilution and shoot procedure proved to be useful for LC-MS/MS and gas chromatography-mass spectrometry determination. The three methodologies were validated following SANTE guidelines, with quantitation limits below the established European Union and Codex Alimentarius maximum residue limits. The developed methodologies are useful tools for the routine control analysis of pesticide residues in lemon matrices, allowing high sample throughput and enhancing labs productivity.

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Pesticide Residues in Natural Products with Pharmaceutical Use: Occurrence, Analytical Advances and Perspectives

Cited by 11 publications

References 95 publications

Pesticides in essential oils and selected fragrance extracts. Some examples. A review

Pesticides in essential oils and selected fragrance extracts. Some examples. A review

Activity prediction of aminoquinoline drugs based on deep learning

Analytical methods for the routinely evaluation of pesticide residues in lemon fruits and by products

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