Pesticide residues in bee bread, propolis, beeswax and royal jelly – A review of the literature and dietary risk assessment

Végh, Rita; Csóka, Mariann; Mednyánszky, Zsuzsanna; Sípos, László

doi:10.1016/j.fct.2023.113806

Cited by 20 publications

(13 citation statements)

References 86 publications

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“…[12][13][14] Unfortunately, overuse of GCs might lead to the harmful residues in animal tissues and then enter the human body through the food chain, thus causing adverse effects including osteoporosis, endocrine disorders, immunosuppression, and disorders of glucose metabolism. [15][16][17][18] Hence, in order to ensure the human health, the European Union has established the maximum residue limits (MRLs) for GCs in animal tissues and foodstuffs. [19] The MRLs of dexamethasone/betamethasone were 0.75 μg/kg in muscle/kidney of cattle/pigs, and 0.3 μg/kg in milk.…”

Section: Introductionmentioning

confidence: 99%

“…GCs have also been widely used in animal husbandry due to their anti‐inflammatory, anti‐shock, and anti‐allergic properties [12–14] . Unfortunately, overuse of GCs might lead to the harmful residues in animal tissues and then enter the human body through the food chain, thus causing adverse effects including osteoporosis, endocrine disorders, immunosuppression, and disorders of glucose metabolism [15–18] . Hence, in order to ensure the human health, the European Union has established the maximum residue limits (MRLs) for GCs in animal tissues and foodstuffs [19] .…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the Glucocorticoid Receptor Binding and Agonist Activities of Typical Glucocorticoids: Insights into Their Endocrine Disrupting Effects

Liang,

Li,

Zhang

et al. 2024

Chemistry & Biodiversity

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Over the past decades, the synthetic glucocorticoids (GCs) have been widely used in clinical practice and animal husbandry. Given the health hazard of these toxic residues in food, it is necessary to explore the detailed interaction mechanisms of typical GCs and their main target glucocorticoid receptor (GR). Hence, this work compared the GR binding and agonist activities of typical GCs. Fluorescence polarization assay showed that these GCs were potent ligands of GR. Their GR binding affinities were in the order of methylprednisolone > betamethasone ≈ prednisolone > dexamethasone, with IC50 values of 1.67, 2.94, 2.95, and 5.58 nM. Additionally, the limits of detection of dexamethasone, betamethasone, prednisolone, and methylprednisolone were 0.32, 0.14, 0.19, and 0.09 μg/kg in fluorescence polarization assay. Reporter gene assay showed that these GCs induced GR transactivation in a dose‐dependent manner, confirming their GR agonist activities. Among which, dexamethasone at the concentration of 100 nM produced a maximal induction of more than 11‐fold over the blank control. Molecular docking and molecular dynamics simulations suggested that hydrogen‐bonding and hydrophobic interactions played an important role in stabilizing the GC‐GR‐LBD complexes. In summary, this work might help to understand the GR‐mediated endocrine disrupting effects of typical GCs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of the Glucocorticoid Receptor Binding and Agonist Activities of Typical Glucocorticoids: Insights into Their Endocrine Disrupting Effects

Liang,

Li,

Zhang

et al. 2024

Chemistry & Biodiversity

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“…One of the major challenges to ensuring food security for global consumers in the world is the development of rapid detection techniques for detecting pesticide residues and their metabolites in foodstuffs. , Their bioaccumulation in agricultural land that is highly dangerous for human health may be derived from unregulated and excessive usage and thus adversely impact the quality and safety of foodstuffs. , Therefore, developing a robust analytical method for detecting residual pesticides in foodstuffs and monitoring their concentration in the environment is necessary. Among those residual pesticides commonly found in foodstuffs, carbaryl as a carbamate family has been widely used to increase production in agricultural lands due to its high efficiency and powerful activity in controlling the population of harmful insects to a variety of plant crops. , When the carbaryl residue occurs in food and subsequently enters the human body, it can cause a great threat and lead to several serious failures and hazards in the metabolic system. − Moreover, the European Union (EU) has regulated the maximum residue limits (MRLs) of carbaryl concentration in several foodstuffs from 0.01 to 0.05 mg kg –1 .…”

Section: Introductionmentioning

confidence: 99%

“… 1 , 2 Their bioaccumulation in agricultural land that is highly dangerous for human health may be derived from unregulated and excessive usage and thus adversely impact the quality and safety of foodstuffs. 3 , 4 Therefore, developing a robust analytical method for detecting residual pesticides in foodstuffs and monitoring their concentration in the environment is necessary. Among those residual pesticides commonly found in foodstuffs, carbaryl as a carbamate family has been widely used to increase production in agricultural lands due to its high efficiency and powerful activity in controlling the population of harmful insects to a variety of plant crops.…”

Section: Introductionmentioning

confidence: 99%

Effect of Aspect Ratio of a Gold-Nanorod-Modified Screen-Printed Carbon Electrode for Carbaryl Detection in Three Different Samples of Vegetables

Wahyuni,

Putra,

Rahman

et al. 2023

ACS Omega

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In this study, three different sizes of gold nanorods (AuNRs) were synthesized using the seed-growth method by adding various volumes of AgNO 3 as 400, 600, and 800 μL into the growth solution of gold nanoparticles. Three different sizes of AuNRs were then characterized using UV−vis spectroscopy, highresolution transmission electron microscopy (HRTEM), selected area electron diffraction (SAED) patterns, and atomic force microscopy (AFM) to investigate the surface morphology, topography, and aspect ratios of each synthesized AuNR. The aspect ratios from the histogram of size distributions of three AuNRs as 2.21, 2.53, and 2.85 can be calculated corresponding to the addition of AgNO 3 volumes of 400, 600, and 800 μL. Moreover, each AuNR in three different aspect ratios was drop-cast onto the surface of a commercial screen-printed carbon electrode (SPCE) to obtain three different SPCE-modified AuNRs (SPCE-A400, SPCE-A600, and SPCE-A800, respectively). All SPCE-modified AuNRs were then evaluated for their electrochemical behavior using cyclic voltammetry and electrochemical impedance spectroscopy (EIS) techniques and the highest electrochemical performance was shown as the order of magnitude of SPCE-A400 > SPCE-A600/SPCE-A800. The reason for the highest electrocatalytic activity of SPCE-A400 might be due to the smallest particle size and uniform distribution of AuNRs ∼ 2.2, which enhanced the charge transfer, thus providing the highest electroactive surface area (0.6685 cm 2 ) compared to other electrodes. These results also confirm that the sensing mechanism for all SPCE-modified AuNRs is controlled by diffusion phenomena. In addition, the optimum pH was obtained as 4 for carbaryl detection for all SPCE-modified AuNRs with the highest current shown by SPCE-A400. Furthermore, SPCE-A400 has the highest fundamental parameters (surface coverage, catalytic rate constant, electron transfer rate constant, and adsorption capacity) for carbaryl detection, which were investigated using cyclic voltammetry and chronoamperometric techniques. The electroanalytical performances of all SPCE-modified AuNRs for carbaryl detection were also investigated with SPCE-A400 displaying the best performance among other electrodes in terms of its linearity (0.2−100 μM), limit of detection (LOD) ∼ 0.07 μM, and limit of quantification (LOQ) ∼ 0.2 μM. All SPCE-modified AuNRs were also subsequently evaluated for their stability, reproducibility, and selectivity in the presence of interfering species such as NaNO 2 , NH 4 NO 3 , Zn(CH 3 CO 2 ) 2 , FeSO 4 , diazinon, and glucose and show reliable results as depicted from %RSD values less than 3%. At last, all SPCE-modified AuNRs have been employed for carbaryl detection using a standard addition technique in three different samples of vegetables (cabbage, cucumber, and Chinese cabbage) with its results (%recovery ≈ 100%) within the acceptable analytical range. In conclusion, this work demonstrates the great potential of a disposable device based on an AuNR-modified SPCE for rapid detection and high ...

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“…Similarly, in the UK, 18% of beekeepers depended solely on amitraz, and 20% utilized a rotation or mixed-method approach to mite treatments (Valentine and Martin, 2023). High concentrations of these chemicals or their metabolites are commonly found in bees, honey, wax, and other components of the hive (Mullin et al, 2010;Kiljanek et al, 2017;Vegh et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Integrated resistance management for acaricide use on Varroa destructor

Lester

2023

Front. Bee Sci.

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The global beekeeping industry faces an escalating challenge in the form of Varroa destructor. Synthetic chemicals serve as a cornerstone for varroa management, although they face a major challenge in the form of acaricide resistance. Here, I examine acaricide resistance in varroa under the framework of Insecticide Resistance Management (IRM). I assess the potential of diverse IRM strategies, such as pesticide rotation and mixtures, refuge utilization, synergists and the integration of non-persistent chemicals. The peculiar life history of varroa, characterized by its incestuous breeding system, challenges conventional IRM strategies. There is little published evidence that pesticide rotation is beneficial for resistance management in varroa, with several studies showing resistance is maintained despite rotation. Fitness costs associated with pesticide resistance are often an essential component for IRM strategies, but there are no current data from varroa demonstrating such specific fitness costs (e.g., a reduced relative oviposition rate) associated with resistance. The single published experimental study directly examining relative fitness found that here was little or no reproductive fitness cost associated with pyrethroid resistance. More work is needed on fitness effects of the key acaricides, which would better guide the use of rotation and refuge strategies. A key prospect for future work that has been identified through simulation modeling is offered by pesticide mixtures and the role of synergists to elevate acaricide efficacy. Additional tools for varroa IRM include ‘soft’ acaricides, including oxalic acid, and biopesticides such as dsRNA. In light of the widespread prevalence of acaricide resistance and an increasing varroa problem, there is an urgent need for nuanced, data-driven varroa IRM strategies.

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Pesticide residues in bee bread, propolis, beeswax and royal jelly – A review of the literature and dietary risk assessment

Cited by 20 publications

References 86 publications

Comparison of the Glucocorticoid Receptor Binding and Agonist Activities of Typical Glucocorticoids: Insights into Their Endocrine Disrupting Effects

Comparison of the Glucocorticoid Receptor Binding and Agonist Activities of Typical Glucocorticoids: Insights into Their Endocrine Disrupting Effects

Effect of Aspect Ratio of a Gold-Nanorod-Modified Screen-Printed Carbon Electrode for Carbaryl Detection in Three Different Samples of Vegetables

Integrated resistance management for acaricide use on Varroa destructor

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