Pesticide mixtures potentiate the toxicity in murine thymocytes

Olgun, Selen; Gogal, Robert M.; Adeshina, Femi; Choudhury, Harlal; Misra, Hara P.

doi:10.1016/j.tox.2003.09.007

Cited by 45 publications

(32 citation statements)

References 38 publications

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“…37) Permethrin, another synthetic pyrethroid, caused concentration-dependent increase in both apoptotic and necrotic cell death in thymocytes. 38) Though these findings indicate a specific role for apoptosis in cypermethrin induced toxicity, it is still premature to draw definite conclusions on the role of apoptosis in environmental pollutant-induced toxicity.…”

Section: )mentioning

confidence: 99%

The Pyrethroid Cypermethrin-Induced Biochemical and Histological Alterations in Rat Liver

Yavaşoğlu

Sayim

Uyanıkgil

et al. 2006

JOURNAL OF HEALTH SCIENCE

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Cypermethrin, a synthetic pyrethroid, has broadspectrum use in agriculture, domestic and veterinary applications due to its high bioefficacy, enhanced stability and considerably low mammalian toxicity. The objective of this study was to investigate the cypermetrin-induced alterations in the liver tissue of Wistar male rats, based on the histopatological, enzymological analyses and apoptotic changes. The animals of the experimental groups were orally fed with laboratory chow combined 60, 150, and 300 mg/kg Kral 250 EC during 28 consecutive days. At the end of the treatment, no significant change was found in relative liver weights, liver total proteins and cholinesterase enzyme activities of cypermethrin treated rats, when compared with control animals. Histopathological changes such as vacuolar degeneration, enlargement of the sinusoids, degeneration in hepatic cords and hepatocytes, vacuole formations in hepatocytes, pleomorphism in nucleus, and congestion were observed in liver tissues of only 150 and 300 mg/kg cypermethrin treated rats. Mononuclear cell infiltration and an increase in the Kupffer cells in liver parenchymatous tissue were also determined. In all cypermethrin treated groups, the apoptotic index in livers of rats was significantly increased compared to control group (p < 0.001). These results suggest that cypermethrin might cause hazardous effects in different levels to non-target organisms.

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confidence: 99%

The Pyrethroid Cypermethrin-Induced Biochemical and Histological Alterations in Rat Liver

Yavaşoğlu

Sayim

Uyanıkgil

et al. 2006

JOURNAL OF HEALTH SCIENCE

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“…The residues of OPPs in plants that have been reported may cause a great damage to human health through food chain [2][3][4][5]. To protect consumers from unsafe level, the Codex Alimentarius Commission of the United Nation's Food and Agriculture Organization and the World Health Organization have established maximal residue limit (MRL) for pesticides over a variety of foods [6].…”

Section: Introductionmentioning

confidence: 99%

Determination of organophosphorus pesticides by capillary electrophoresis‐inductively coupled plasma mass spectrometry with collective sample‐introduction technique

Gao

Shen

et al. 2009

Electrophoresis

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A new method for the determination of organophosphorus pesticides using CE-ICP-MS with collective sample-introduction technique has been developed in this study. The method has been successfully used to separate and determine dimethoate, trichlorfon and glyphosate with an RSD of < 5% for migration times (n = 6) and < 4% for peak areas (n = 6). The experimental results showed that the collective sample-introduction considerably reduced the makeup volume and the dilution of analyte, and eventually resulted in a much lower detection limit and a much better electrophoretic resolution. The peak widths and the detection limits of dimethoate, trichlorfon and glyphosate obtained with this method are 15-17 s and 0.05-0.07 microg/mL (as compound), respectively. Using this method, we have successfully separated and determined dimethoate, trichlorfon and glyphosate in vegetable sample with a recovery of 90-96%.

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“…Pesticides vary in their toxicity mechanism and character, e.g. they can be carcinogenic or mutagenic, or they can affect the respiratory, endocrine, immune or nervous systems (13)(14)(15)(16). We determined the sensitivity of bioluminescence tests included in the BSS to different types of toxicants (organophosphates, derivatives of dithiocarbamide acid, and pyrethroid preparations) and tested the potential of the bioluminescence technique for early detection of terrorist attacks involving chemical weapons.…”

Section: Introductionmentioning

confidence: 99%

A bioluminescent signal system: detection of chemical toxicants in water

Vetrova

Esimbekova

Remmel³

et al. 2007

Luminescence

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Prototype technologies of a bioluminescent signal system (BSS) based on the luminous bacterium Photobacterium phosphoreum and three enzymatic bioluminescence systems have been proposed for detecting and signalling the presence of toxicants in water systems. A number of pesticides, mostly known as poisonous substances, similar in their structures and physicochemical properties, have been taken as model compounds of chemical agents. The effect of toxicants (organophosphates, derivatives of dithiocarbamide acid, and pyrethroid preparations) on the bioluminescence of the four systems has been analysed. EC(50) and EC(80) have been determined and compared to the maximum permissible concentration for each of the analysed substances. The triple-enzyme systems with ADH and trypsin have been shown to be more sensitive to organophosphorous compounds (0.13-11 mg/L), while the triple-enzyme system with trypsin is highly sensitive to lipotropic poison, a derivative of dithiocarbamine acid (0.03 mg/L). Sensitivities of the triple-enzyme systems to pyrethroid preparations are similar to those of luminous bacteria (0.9-5 mg/L). The results can be used to construct an alarm-test bioluminescence system for detecting chemical toxicants, based on intact bacteria or enzyme systems.

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Pesticide mixtures potentiate the toxicity in murine thymocytes

Cited by 45 publications

References 38 publications

The Pyrethroid Cypermethrin-Induced Biochemical and Histological Alterations in Rat Liver

The Pyrethroid Cypermethrin-Induced Biochemical and Histological Alterations in Rat Liver

Determination of organophosphorus pesticides by capillary electrophoresis‐inductively coupled plasma mass spectrometry with collective sample‐introduction technique

A bioluminescent signal system: detection of chemical toxicants in water

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