Pesticide exposure and Parkinson's disease: Epidemiological evidence of association

Freire, Carmen; Koifman, Sérgio

doi:10.1016/j.neuro.2012.05.011

Cited by 220 publications

(121 citation statements)

References 100 publications

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“…From epidemiological studies it is now known that a relationship exists between exposure to certain classes of pesticides and the occurrence of Parkinson's disease (PD) (Rajput & Birdi 1997;Elbaz & Tranchant 2007;Freire & Koifman 2012;Mostafalou & Abdollahi 2013), although the underlying neurotoxic mechanisms are often unknown.…”

Section: Toxicity Of Pesticides In Humansmentioning

confidence: 99%

“…However, considerable heterogeneity in the available studies precludes conclusiveness as to which class of pesticides is involved (van der Mark et al 2011). Available epidemiological studies point towards an increased risk associated with insecticides (in particular organochlorine insecticides; Elbaz et al 2009;Freire & Koifman 2012) and herbicides (Pezzoli & Cereda 2013). Interestingly, the epidemiological evidence for the involvement of organochlorine insecticides is underlined by biomarkers of exposure in serum (Weisskopf et al 2010) and post mortem detection of elevated levels of particular organochlorine insecticides in brains of PD patients (Corrigan et al 1996;Corrigan et al 2000).…”

Section: The Role Of Pesticides In Pdmentioning

confidence: 99%

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In vitrodopaminergic neurotoxicity of pesticides: a link with neurodegeneration?

Heusinkveld

Berg

Westerink

2014

Veterinary Quarterly

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Section: Toxicity Of Pesticides In Humansmentioning

confidence: 99%

Section: The Role Of Pesticides In Pdmentioning

confidence: 99%

In vitrodopaminergic neurotoxicity of pesticides: a link with neurodegeneration?

Heusinkveld

Berg

Westerink

2014

Veterinary Quarterly

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“…Paraquat) [18], but they can also cause severe or lethal poisoning in humans [19]. Interestingly, there are growing data indicating the association between chronic Paraquat exposure and Parkinson's disease [20][21][22]. The mechanism of viologen toxicity involves the induction of the generation of superoxide anions and other ROS, which leads to cell and tissue damage [23,24].…”

Section: Introductionmentioning

confidence: 99%

Viologen-phosphorus dendrimers exhibit minor toxicity against a murine neuroblastoma cell line

Łaźniewska

Miłowska

Katir

et al. 2013

Cellular and Molecular Biology Letters

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Dendrimers containing viologen (derivatives of 4,4'-bipyridyl) units in their structure have been demonstrated to exhibit antiviral activity against human immunodeficiency virus (HIV-1). It has also recently been revealed that novel dendrimers with both viologen units and phosphorus groups in their structure show different antimicrobial, cytotoxic and hemotoxic properties, and have the ability to influence the activity of cholinesterases and to inhibit α-synuclein fibrillation. Since the influence of viologen-phosphorus structures on basic cellular processes had not been investigated, we examined the impact of such macromolecules on the murine neuroblastoma cell line (N2a). We selected three water-soluble viologen-phosphorus (VPD) dendrimers, which differ in their core structure, number of viologen units and number and type of surface groups, and analyzed several aspects of the cellular response. These included cell viability, generation of reactive oxygen species (ROS), alterations in mitochondrial activity, morphological modifications, and the induction of apoptosis and necrosis. The MTT assay results suggest that all of the tested dendrimers are only slightly cytotoxic. Although some changes in ROS formation and mitochondrial function were detected, the three compounds did not induce apoptosis or necrosis. In light of these results, we can assume that the tested VPD are relatively safe for mouse neuroblastoma cells. Although more research on their safety is needed, VPD seem to be promising nanoparticles for further biomedical investigation.

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“…External factors: External or environmental factors have been associated with an increased risk of PD, including pesticide exposure, head injuries, and living in the country or farming [26].Rural environments and drinking of well water may be risks, as they are indirect measures of exposure to pesticides [11].Implicated agents include insecticides, primarily chlorpyrifos and organochlorines [27],and pesticides, suchasrotenone,orparaquat,andherbicides, such as Agent Orange and ziram [11].Exposure to heavy metals has been proposed to be a risk factor, through possible accumulation in the substantia nigra,but studies on the issue have been inconclusive [11].…”

Section: Contributory Factorsmentioning

confidence: 99%

Gut-Microbiota Link in Parkinson’s Disease: Current Perspectives

Mustafa¹,

Menon²,

Mansur³

et al. 2017

IOSR JDMS

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Abstract:Parkinson's disease(PD) is a metacentric neurodegenerative disorder results with accumulation and aggregation of alpha-synculein(α-Syn) (or alpha-synculeinopathy) Brain -gut axis(GBA) refers to central nervous system(CNS) control of the enteric nervous system(ENS) through vagus nerve intervention. PD is characterized by alphasynculeinopathy affecting all levels of the brain-gut axis.Both clinical and neuropathological evidences indicate the neurodegenerative changes in

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Pesticide exposure and Parkinson's disease: Epidemiological evidence of association

Cited by 220 publications

References 100 publications

In vitrodopaminergic neurotoxicity of pesticides: a link with neurodegeneration?

In vitrodopaminergic neurotoxicity of pesticides: a link with neurodegeneration?

Viologen-phosphorus dendrimers exhibit minor toxicity against a murine neuroblastoma cell line

Gut-Microbiota Link in Parkinson’s Disease: Current Perspectives

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