Pesticide exposure among Czech adults and children from the CELSPAC-SPECIMEn cohort: Urinary biomarker levels and associated health risks

Šulc, Libor; Janoš, Tomáš; Figueiredo, Daniel; Ottenbros, Ilse; Šenk, Petr; Mikeš, Ondřej; Huss, Anke; Čupr, Pavel

doi:10.1016/j.envres.2022.114002

Cited by 11 publications

(6 citation statements)

References 63 publications

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“…Importantly, 3-PBA exposure was found to be higher in the summer, when compared to winter-collected urine samples. Several studies have shown that urinary pyrethroid metabolite levels of pregnant women follow trends of seasonal insecticide use related to pest management practice [ 24 , 33 , 34 , 35 , 36 ]. A study carried out in China also observed a trend of seasonal variation, with levels of urinary metabolites in the summer significantly higher than those in the winter.…”

Section: Discussionmentioning

confidence: 99%

“…So, the aims of this study were to characterize the exposure of pregnant women living in Portugal to 3-PBA and to evaluate the association of this exposure with maternal outcomes and newborn anthropometric measures. Additionally, considering that the exposure of the global population to 3-PBA is expected to vary with the seasons [ 24 , 33 , 34 , 35 ], with the maximum likelihood of exposure in summer [ 36 ], we decided to compare samples collected in summer with those collected in winter.…”

Section: Introductionmentioning

confidence: 99%

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Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study

Guimarães

Bracchi

Pinheiro

et al. 2023

Toxics

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The aims of this study were to characterize the exposure of pregnant women living in Portugal to 3-phenoxybenzoic acid (3-PBA) and to evaluate the association of this exposure with maternal outcomes and newborn anthropometric measures. We also aimed to compare exposure in summer with exposure in winter. Pregnant women attending ultrasound scans from April 2018 to April 2019 at a central hospital in Porto, Portugal, were invited to participate. Inclusion criteria were: gestational week between 10 and 13, confirmed fetal vitality, and a signature of informed consent. 3-PBA was measured in spot urine samples by gas chromatography with mass spectrometry (GC-MS). The median 3-PBA concentration was 0.263 (0.167; 0.458) µg/g creatinine (n = 145). 3-PBA excretion was negatively associated with maternal pre-pregnancy body mass index (BMI) (p = 0.049), and it was higher during the summer when compared to winter (p < 0.001). The frequency of fish or yogurt consumption was associated positively with 3-PBA excretion, particularly during the winter (p = 0.002 and p = 0.015, respectively), when environmental exposure is low. Moreover, 3-PBA was associated with levothyroxine use (p = 0.01), a proxy for hypothyroidism, which could be due to a putative 3-PBA—thyroid hormone antagonistic effect. 3-PBA levels were not associated with the anthropometric measures of the newborn. In conclusion, pregnant women living in Portugal are exposed to 3-PBA, particularly during summer, and this exposure may be associated with maternal clinical features.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study

Guimarães

Bracchi

Pinheiro

et al. 2023

Toxics

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“…The values of all 8 BTs were then summed for each participant. The estimation of daily intake was undertaken using the following formula derived from an equation used in previous studies (Katsikantami et al 2019 ; Šulc et al 2022 ): where EDI is Estimated Daily Intake, c U is the SG-adjusted concentration of BTs in urine, V UO is the urine output volume (1.7 L/day (Perucca et al 2007 )), F UE is the urinary excretion factor, and b.w. is the body weight of the participant.…”

Section: Methodsmentioning

confidence: 99%

Exposure to benzotriazoles and benzothiazoles in Czech male population and its associations with biomarkers of liver function, serum lipids and oxidative stress

Pálešová,

Bláhová,

Janoš

et al. 2024

Int Arch Occup Environ Health

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Introduction Benzotriazoles and benzothiazoles (BTs) are high-production volume chemicals as well as widely distributed emerging pollutants with potential health risk. However, information about human exposure to BTs and associated health outcomes is limited. Objective We aimed to characterise exposure to BTs among Czech men, including possible occupational exposure among firefighters, its predictors, and its associations with liver function, serum lipids and oxidative stress. Methods 165 participants (including 110 firefighters) provided urine and blood samples that were used to quantify the urinary levels of 8 BTs (high-performance liquid chromatography-tandem mass spectrometry), and 4 liver enzymes, cholesterol, low-density lipoprotein, and 8-hydroxy-2’-deoxyguanosine. Linear regression was used to assess associations with population characteristics and biomarkers of liver function, serum lipids and oxidative stress. Regression models were adjusted for potential confounding variables and false discovery rate procedure was applied to account for multiplicity. Results The BTs ranged from undetected up to 46.8 ng/mL. 2-hydroxy-benzothiazole was the most predominant compound (detection frequency 83%; median 1.95 ng/mL). 1-methyl-benzotriazole (1M-BTR) was measured in human samples for the first time, with a detection frequency 77% and median 1.75 ng/mL. Professional firefighters had lower urinary 1M-BTR compared to non-firefighters. Urinary 1M-BTR was associated with levels of γ-glutamyl transferase (β = − 17.54%; 95% CI: − 26.127, − 7.962). Conclusion This is the first study to investigate BT exposure in Central Europe, including potentially exposed firefighters. The findings showed a high prevalence of BTs in the study population, the relevance of 1M-BTR as a new biomarker of exposure, and an urgent need for further research into associated adverse health outcomes. Graphical abstract

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“…Residents living in agricultural areas were also exposed to pesticides by breathing or drinking water. However, a study conducted in the Czech Republic revealed that pesticide exposure was primarily influenced by dietary intake, with environmental exposure having a less significant effect, thus the number of studies investigating the link between urinary pesticides and dietary intake (14), among which four studies investigated the effect of organic diet intervention on urinary pesticides. ,,, …”

Section: Characteristics and Scopes Of Urinary Pesticides Researchmentioning

confidence: 99%

“…This mainly revolves around how pesticides are applied, and their chemical and physical properties, including whether they tend to evaporate or adhere to plants. No significant differences were found between some biomarker levels in samples collected during the nonspray and spray seasons in a study conducted on farmworkers in South Western Idaho and Czech Republic. , Stable exposure during seasons suggests that exposure was mainly driven by diet and that the effect of environmental exposure was less significant.…”

Section: Demographic and Lifestyle Variablesmentioning

confidence: 99%

A Comprehensive Review on Pesticide Residues in Human Urine

Hakme,

Poulsen,

Lassen

2024

J. Agric. Food Chem.

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Numerous studies worldwide have evaluated pesticide residues detected in urine. This review serves as a contribution to this field by presenting an overview of scientific research studies published from 2001 to 2023, including details of study characteristics and research scope. Encompassing 72 papers, the review further delves into addressing key challenges in study design and method used such as sampling and analytical approaches, results adjustments, risk assessment, estimations, and results evaluation. The review explores urinary concentrations and detection frequency of metabolites of organophosphates and pyrethroids, as well as herbicides such as 2,4-D and glyphosate and their metabolites, across various studies. The association of the results with demographic and lifestyle variables were explored. While farmers generally have higher pesticide exposure, adopting organic farming practices can reduce the levels of pesticides detected in their urine. Residence close to agricultural areas has shown high exposure in some cases. Dietary exposure is especially high among people adopting a conventionally grown plant-rich dietary pattern. A higher detection level and frequency of detection are generally found in females and children compared to males. The implications of transitioning to organic and sustainable plant-rich diets for reducing pesticide exposure and potential health benefits for both adults and children require further investigation.

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Pesticide exposure among Czech adults and children from the CELSPAC-SPECIMEn cohort: Urinary biomarker levels and associated health risks

Cited by 11 publications

References 63 publications

Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study

Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study

Exposure to benzotriazoles and benzothiazoles in Czech male population and its associations with biomarkers of liver function, serum lipids and oxidative stress

A Comprehensive Review on Pesticide Residues in Human Urine

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