Peste des Petits Ruminants’lı Kuzularda Klinik, Hematolojik, Biyokimyasal ve Patolojik Bulgular

Clinical Investigation of the Pathogenicity of Pasteurella multocida Isolated from Cattle in Egypt Regarding its Effect on Hematological, Biochemical, and Oxidant-Antioxidant Biomarkers as well as Proinflammatory Cytokines and Acute Phase Proteins

“…This comes in line with Šoltésová et al (2015), who stated that the increase in WBCs, mainly neutrophils, was a common finding in many diseases as a consequence of inflammatory processes, such as respiratory diseases in the sick calves. Lymphopenia in the diseased cattle was consistent with Aytekin et al (2011), who attributed lymphopenia to stress response and endogenous release of corticosteroids, which lead to redistribution of recirculating lymphocytes, resulting in their sequestration in the lymphoid tissues instead of entering efferent lymph and blood to participate in the developing inflammation.…”

“…These changes may be attributed to the mononuclear phagocytic system, which becomes hyperplastic, trapping free iron, and hence increases iron storage in phagocytic cells after inflammation. Decreases in iron transfer to developing erythroid cells in the bone marrow leads to a reduction in Hb (Aytekin et al, 2011). Other inflammatory cytokines may share in producing anemia, such as IL1, suppress the proliferation of erythroid precursors in the bone marrow or inhibit the production of erythropoietin in the kidney; in addition, TNF-α-mediated damages erythrocyte membranes (Weiss and Goodnough, 2005).…”

Clinicobiochemical and GC-MS Based Serum Metabolomics for determination of Therapeutic Efficacy of Silymarin in Pneumonic Sheep

“…The same results were recorded [23; 24]. The increase of these liver function tests may be due to hepatic cellular damage and degenerative modi cations brought on by bacterial infection and its toxins [25], or due to severe exposure to oxidative stress resulting in damage of phospholipid structure of hepatic cell membrane [21],…”