Pesquisa de enterovírus em casos de síndrome de meningite asséptica de Belém, PA

Lamarão, Letícia Martins; Gomes, Maria de Lourdes Contente; Ferreira, Lauze Lee Alves; Fonseca, C. M. F; Araújo, Lia C.; Santana, Marquete B.; Tavares-Neto, José

doi:10.1590/s0037-86822005000500005

Cited by 10 publications

(11 citation statements)

References 16 publications

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“…Another study in northern Brazil found 13.2% of positive CSF samples for enterovirus using cellular culture, immunofluorescence and neutralization test. The authors reported the importance of determining a national picture of viral meningitis in Brazil since it is still incomplete 18 . Despite the use of different methodologies, the proportion of positive samples was similar to that observed in this study.…”

Section: Discussionmentioning

confidence: 99%

Enterovirus and herpesviridae family as etiologic agents of lymphomonocytary meningitis, Southern Brazil

Vidal

Almeida²,

Messias-Reason³

et al. 2011

Arq. Neuro-Psiquiatr.

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Viral meningitis is a common infectious disease of the central nervous system (CNS) that occurs worldwide. The aim of this study was to identify the etiologic agent of lymphomonocytary meningitis in Curitiba, PR, Brazil. During the period of July 2005 to December 2006, 460 cerebrospinal fluid (CSF) samples with lymphomonocytary meningitis were analyzed by PCR methodologies. Fifty nine (12.8%) samples were positive. Enteroviruses was present in 49 (83%) samples and herpes virus family in 10 (17%), of these 6 (10%) herpes simplex virus, 1 (2%) Epstein Barr virus, 2 (3%) human herpes virus type 6 and 1 (2%) mixed infection of enterovirus and Epstein Barr virus. As conclusion enterovirus was the most frequent virus, with circulation during summer and was observed with higher frequency between 4 to 17 years of age. PCR methodology is an important method for rapid detection of RNA enterovirus and DNA herpesvirus in CSF.

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Section: Discussionmentioning

confidence: 99%

Enterovirus and herpesviridae family as etiologic agents of lymphomonocytary meningitis, Southern Brazil

Vidal

Almeida²,

Messias-Reason³

et al. 2011

Arq. Neuro-Psiquiatr.

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“…Some viral strains can present low affinity to a specific monoclonal antibody due to mutations leading to antigenic changes in the target epitope occurring, therefore, not recognition by monoclonal antibody (3). Specific MAb directed to EV-4 can present low cross-reaction with EV-30, EV-6 and EV-11 MAbs (3,16). In our study cross-reaction between EV-4 and EV-30 MAbs was observed in 2 samples.…”

Section: Discussionmentioning

confidence: 46%

“…In Spain a study reported cases associated to viral meningitis, during the period from 1988 to 1997 with a high incidence of HEV and the predominance of EV-30 (90%) among non-polio serotype (36). This serotype was responsible for aseptic meningitis epidemics in Japan in 1991 and 1997 (39, 40), Switzerland in 1996 (13), Canada in 1998 (4), Romania in 1999 (5), and more recently published, in Turkey in 1999 (26), France in 2000 (7), Belgium in 2000 (35) and Brazil in 2003 (16,2). Our retrospective study agrees with literature data.…”

Section: Discussionmentioning

confidence: 97%

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Aseptic meningitis by echovirus 30 in São Paulo state, Brazil

Machado¹,

Ferreira²,

Carmona³

et al. 2007

Braz. J. Microbiol.

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The objective of this study was to identify and characterize the immunological and molecular aspects of Human Enterovirus (HEV) associated with aseptic meningitis cases in São Paulo State, Brazil. Clinical samples (cerebrospinal fluid CSF, stool and sera) were analyzed from 21 viral meningitis suspected cases collected in the period from 1998 to 1999. The isolated virus were identified as belonging to Enterovirus genus and specifically to echovirus serotype 30 (EV-30), using immunological techniques as Indirect Immunofluorescense Assay (IFA) and Neutralization (Nt) and by molecular technique of Reverse Transcription Polymerase Chain Reaction (RT-PCR) directed to the 5'NTR and VP1 regions of viral genome. The results obtained contributed with to the surveillance system of São Paulo State and they are important due to a shortage of epidemiological data about the circulation of EV-30 associated to aseptic meningitis in this region of the world.

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“…In Brazil during the 1960s, Godoy et al [8] reported cases of AM associated with enteroviruses. Later studies have confirmed this association [9][10][11][12][13], including two outbreaks of Echo 30 [14,15]. Classic virology methods, using cell culture, are routinely used to detect EV in clinical specimens.…”

mentioning

confidence: 99%