Perylenediimide chromophore as an efficient photothermal agent for cancer therapy

Zhang, Shaobo; Li, Jianhao; Wei, Jie; Yin, Meizhen

doi:10.1016/j.scib.2017.12.015

Cited by 50 publications

(24 citation statements)

References 41 publications

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“…[2][3] Recently,n anoscale drug carriers have been reported as an effective methodt oc ircumvent MDR and they offer ar emarkable intracellulard rug delivery mechanism to improvea nticancer efficacy. [4][5][6][7][8][9][10] Reduced graphene-based drug-delivery systems have attracted the most attention because of their unique physical, electrical and chemicalp roperties, andt hey have been widely used as biomedical treatments, particularly for use in photothermal therapy( PTT) and cell imaging. [11][12][13][14][15][16][17][18][19][20][21][22] PTT is one of the mostp rominentm ethods for the application of rGO-based nanodrug systems.…”

Section: Introductionmentioning

confidence: 99%

The Fabrication of rGO/(PLL/PASP)₃@DOX Nanorods with pH‐Switch for Photothermal Therapy and Chemotherapy

Zhang

Meng

et al. 2018

Chemistry A European J

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The development of well-controlled drug carriers that are stable and highly effective for the delivery of anticancer agents is challenging. Herein, we report a novel pH-controlled drug delivery system, utilizing reducing graphene oxide (rGO)-polymer self-assembly films as carriers, for the preparation of effective drug nanorods and nanoparticles. In this system, the rGO-polymer carriers were constructed by the alternating assembly of poly-l-lysine (PLL) and polyaspartic acid (PASP) around the rGO sheets. Furthermore, the rGO-polymer cores, which possess a positively charged surface as the desired template, could assemble with negatively charged doxorubicin (DOX) via electrostatic interactions. The DOX embedding efficiency and the morphology of the drug nanocomposites could be controlled by the number of rGO-polymer bilayers and concentration of the rGO-polymer bilayers and the initial DOX concentration. Importantly, the release of DOX could be regulated by controlling the pH and by using a NIR laser. Under acidic conditions, the interactions between the PASP layer and DOX molecules can be broken, resulting in gradual release of the DOX molecules. Upon NIR irradiation, the release of DOX could be further accelerated and a photothermal effect from rGO induced. Cellular uptake and cytotoxicity experiments indicate that the drug nanocomposites possess effective anticancer activity. Thus, in this work, we present a useful strategy for the fabrication of pH-responsive drug nanocomposites for combined photothermal and chemical therapy. The nanocomposite can be used as a potential drug delivery system for practical cancer treatment.

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Section: Introductionmentioning

confidence: 99%

The Fabrication of rGO/(PLL/PASP)₃@DOX Nanorods with pH‐Switch for Photothermal Therapy and Chemotherapy

Zhang

Meng

et al. 2018

Chemistry A European J

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“…Based on these results,t he in vitro therapeutic effect of PTN was further evaluated by the Cell Counting Kit-8 assay. [21] In the dark, ICy5 exhibits low dark toxicity in both cancer cells and normal cells ( Figure 3D;S upporting Information, Figure S34). Also,P TN shows ac omparable cell toxicity to that of free CPT (Supporting Information, Figure S35).…”

Section: Angewandte Chemiementioning

confidence: 97%

A Size‐Reducible Nanodrug with an Aggregation‐Enhanced Photodynamic Effect for Deep Chemo‐Photodynamic Therapy

Gao

Dong

et al. 2018

Angewandte Chemie

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Fluorescent dyes with multi-functionality are of great interest for photo-based cancer theranostics.H owever, their lowsinglet oxygen quantum yield impedes their potential applications for photodynamic therapy(PDT). Now, amolecular self-assembly strategy is presented for an anodrug with ar emarkably enhanced photodynamic effect based on ad yechemodrug conjugate.The self-assembled nanodrug possesses an increased intersystem crossing rate owingtothe aggregation of dye,l eading to ad istinct singlet oxygen quantum yield (F( 1 O 2 )). Subsequently,u pon red light irradiation, the generated singlet oxygen reduces the sizeofthe nanodrug from 90 to 10 nm, which facilitates deep tumor penetration of the nanodrug and release of chemodrug. The nanodrug achieved in situ tumor imaging and potent tumor inhibition by deep chemo-PDT.O ur work verifies af acile and effective selfassembly strategy to construct nanodrugs with enhanced performance for cancer theranostics.

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“…Compared to the traditional chemotherapy, nano-based delivery systems make it accessible to co-load chemotherapeutic compounds and chemosensitizing agents, including transporter protein inhibitors or gene-silencing agents, into one nanocarrier [23][24][25][26][27][28][29][30]. With continued elaborate engineering, through chemical modification or physical coating, such nano delivery systems can be tailored to serve a wealth of functions, such as active tumor targeting, environmentally-responsive drug release, and image-guided cancer theranostics [31][32][33]. Consequently, it is available to realize enhanced specificity to tumor sites, improved therapeutic index of MDR cancer, as well as decreased toxicity.…”

Section: Introductionmentioning

confidence: 99%

Environmentally responsive dual-targeting nanotheranostics for overcoming cancer multidrug resistance

et al. 2019

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Perylenediimide chromophore as an efficient photothermal agent for cancer therapy

Cited by 50 publications

References 41 publications

The Fabrication of rGO/(PLL/PASP)₃@DOX Nanorods with pH‐Switch for Photothermal Therapy and Chemotherapy

The Fabrication of rGO/(PLL/PASP)₃@DOX Nanorods with pH‐Switch for Photothermal Therapy and Chemotherapy

A Size‐Reducible Nanodrug with an Aggregation‐Enhanced Photodynamic Effect for Deep Chemo‐Photodynamic Therapy

Environmentally responsive dual-targeting nanotheranostics for overcoming cancer multidrug resistance

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Perylenediimide chromophore as an efficient photothermal agent for cancer therapy

Cited by 50 publications

References 41 publications

The Fabrication of rGO/(PLL/PASP)3@DOX Nanorods with pH‐Switch for Photothermal Therapy and Chemotherapy

The Fabrication of rGO/(PLL/PASP)3@DOX Nanorods with pH‐Switch for Photothermal Therapy and Chemotherapy

A Size‐Reducible Nanodrug with an Aggregation‐Enhanced Photodynamic Effect for Deep Chemo‐Photodynamic Therapy

Environmentally responsive dual-targeting nanotheranostics for overcoming cancer multidrug resistance

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The Fabrication of rGO/(PLL/PASP)₃@DOX Nanorods with pH‐Switch for Photothermal Therapy and Chemotherapy

The Fabrication of rGO/(PLL/PASP)₃@DOX Nanorods with pH‐Switch for Photothermal Therapy and Chemotherapy