Peruvian genetic structure and their impact in the identification of Andean missing persons: A perspective from Ayacucho

Iannacone, Gian Carlo; Parra, Roberto C.; Bermejo, Marta Bermejo; Rojas, Yury Gorety Medina; Valencia, C. Alexander; Portugues, L.; Medina, M.; Vallejo, A.R.; Prochanow, A.

doi:10.1016/j.fsigss.2011.09.008

Cited by 7 publications

(4 citation statements)

References 2 publications

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“…A study of dermatoglyphic patterns 33 detected similar features between northern and central Peruvian subpopulations, but they were both differentiated from highlanders of the Puno region (Titicaca Lake). In a recent study using STR markers, 34 Peruvians were suggested to be clustered in three main subgroups according to their geographical locations (north, central and south of Peru) and reported about 30% of admixture with nonautochthonous populations, a similar overall value compared with our results using K ¼ 2 ( Table 1).…”

Section: Discussionsupporting

confidence: 88%

Tracing the genomic ancestry of Peruvians reveals a major legacy of pre-Columbian ancestors

et al. 2013

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In order to investigate the underlying genetic structure and genomic ancestry proportions of Peruvian subpopulations, we analyzed 551 human samples of 25 localities from the Andean, Amazonian, and Coastal regions of Peru with a set of 40 ancestry informative insertion-deletion polymorphisms. Using genotypes of reference populations from different continents for comparison, our analysis indicated that populations from all 25 Peruvian locations had predominantly Amerindian genetic ancestry. Among populations from the Titicaca Lake islands of Taquile, Amantani, Anapia, and Uros, and the Yanque locality from the southern Peruvian Andes, there was no significant proportion of non-autochthonous genomes, indicating that their genetic background is effectively derived from the first settlers of South America. However, the Andean populations from San Marcos, Cajamarca, Characato and Chogo, and coastal populations from Lambayeque and Lima displayed a low but significant European ancestry proportion. Furthermore, Amazonian localities of Pucallpa, Lamas, Chachapoyas, and Andean localities of Ayacucho and Huancayo displayed intermediate levels of non-autochthonous ancestry, mostly from Europe. These results are in close agreement with the documented history of post-Columbian immigrations in Peru and with several reports suggesting a larger effective size of indigenous inhabitants during the formation of the current country's population.

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Section: Discussionsupporting

confidence: 88%

Tracing the genomic ancestry of Peruvians reveals a major legacy of pre-Columbian ancestors

et al. 2013

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“…For example, we observe excess allele sharing of the NorthPeruCoast individuals with Sechura (a present-day North Peru Coast group) compared to Puno (a present-day Titicaca Basin group). Thus, the forced migrations imposed by the Inca and Spanish in these regions did not completely disrupt the genetic population structure that existed prior to these events ( Iannacone et al., 2011 ). Another example is significantly more allele sharing of CentralPeruCoast with Quechua speakers relative to Aymara speakers from the same region ( Reich et al., 2012 ), and, conversely, significantly more allele sharing of NorthChile and Titicaca Basin groups with Aymara speakers relative to Quechua speakers.…”

Section: Resultsmentioning

confidence: 99%

A Paleogenomic Reconstruction of the Deep Population History of the Andes

Nakatsuka

Lazaridis

Barbieri

et al. 2020

Cell

101

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Summary There are many unanswered questions about the population history of the Central and South Central Andes, particularly regarding the impact of large-scale societies, such as the Moche, Wari, Tiwanaku, and Inca. We assembled genome-wide data on 89 individuals dating from ∼9,000-500 years ago (BP), with a particular focus on the period of the rise and fall of state societies. Today’s genetic structure began to develop by 5,800 BP, followed by bi-directional gene flow between the North and South Highlands, and between the Highlands and Coast. We detect minimal admixture among neighboring groups between ∼2,000–500 BP, although we do detect cosmopolitanism (people of diverse ancestries living side-by-side) in the heartlands of the Tiwanaku and Inca polities. We also highlight cases of long-range mobility connecting the Andes to Argentina and the Northwest Andes to the Amazon Basin. Video Abstract

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“…As regarding Peru, the genomic ancestry proportions based on autosomal STRs showed 30% of admixture with non-Native American populations [ 47 ], while proportions provided by INDEL polymorphisms in Peruvians from Coast, Andes and Amazon were identified as 83% Native American and 17% non-autochthonous, mainly from Europe [ 48 ]. These proportions allowed us to consider the results obtained by DAPC reliable ( Fig 4 ).…”

Section: Discussionmentioning

confidence: 99%

Signs of continental ancestry in urban populations of Peru through autosomal STR loci and mitochondrial DNA typing

et al. 2018

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The human genetic diversity around the world was studied through several high variable genetic markers. In South America the demic consequences of admixture events between Native people, European colonists and African slaves have been displayed by uniparental markers variability. The mitochondrial DNA (mtDNA) has been the most widely used genetic marker for studying American mixed populations, although nuclear markers, such as microsatellite loci (STRs) commonly used in forensic science, showed to be genetically and geographically structured. In this work, we analyzed DNA from buccal swab samples of 296 individuals across Peru: 156 Native Amazons (Ashaninka, Cashibo and Shipibo from Ucayali, Huambiza from Loreto and Moche from Lambayeque) and 140 urban Peruvians from Lima and other 33 urban areas. The aim was to evaluate, through STRs and mtDNA variability, recent migrations in urban Peruvian populations and to gain more information about their continental ancestry. STR data highlighted that most individuals (67%) of the urban Peruvian sample have a strong similarity to the Amazon Native population, whereas 22% have similarity to African populations and only ~1% to European populations. Also the maternally-transmitted mtDNA confirmed the strong Native contribution (~90% of Native American haplogroups) and the lower frequencies of African (~6%) and European (~3%) haplogroups. This study provides a detailed description of the urban Peruvian genetic structure and proposes forensic STRs as a useful tool for studying recent migrations, especially when coupled with mtDNA.

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Peruvian genetic structure and their impact in the identification of Andean missing persons: A perspective from Ayacucho

Cited by 7 publications

References 2 publications

Tracing the genomic ancestry of Peruvians reveals a major legacy of pre-Columbian ancestors

Tracing the genomic ancestry of Peruvians reveals a major legacy of pre-Columbian ancestors

A Paleogenomic Reconstruction of the Deep Population History of the Andes

Signs of continental ancestry in urban populations of Peru through autosomal STR loci and mitochondrial DNA typing

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