Pertussis toxin-induced histamine sensitisation: an aspecific phenomenon independent from the nitric oxide system?

Meijeren, Cornelia E. van; Vleeming, W.; Kuil, Ton van de; Gerards, Anne-Loes E; Hendriksen, Coenraad; Wildt, Dick J. De

doi:10.1016/j.ejphar.2004.04.014

Cited by 6 publications

(1 citation statement)

References 38 publications

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“…12 Pertussis toxin results in vasodilatation by reducing the contractile properties of smooth muscle cells in resistance arteries, leading to oedema. 13 Pertussis toxin is also responsible for lymphocytosis, which was another systemic response to B. pertussis infection seen in our patient. While neutrophilia is common in cases of bacterial infection, lymphocytosis is characteristic for B. pertussis infection and can even be used as a prognostic marker for poor outcomes.…”

Section: Case Reportsupporting

confidence: 51%

Angioedema as a predominant symptom ofBordetella pertussisinfection

et al. 2021

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A 41-year-old woman was referred to our hospital with a 6-week history of severe angioedema, dyspnoea and coughing. Initial investigations focused on common causes of angioedema. Clinical presentation and resistance to treatment with antihistamines and steroids made histamine-mediated angioedema unlikely. Bradykinin-mediated angioedema, such as hereditary or drug-induced angioedema, was excluded by a thorough history investigation and laboratory testing for C1-esterase and C4.In rare cases, exogen pathogens cause angioedema. After profound testing for respiratory pathogens, Bordetella pertussis toxins IgA and IgG were found to be positive, indicating recent B. pertussis infection. Pertussis toxin may be responsible for increased vascular permeability causing angioedema. With adequate antibiotic treatment, the symptoms resolved quickly.This case is an example of an atypical presentation of B. pertussis infection in an unvaccinated adult. The recent resurgence of pertussis makes early diagnosis and disease prevention by vaccination crucial.

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Section: Case Reportsupporting

confidence: 51%