Pertussis Antibodies in Pregnant Women

Mishulow, Lucy

doi:10.1001/archpedi.1942.02010100034003

Cited by 19 publications

(1 citation statement)

References 10 publications

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“…In the United States, current medical practice recommends that immunization begin at 2 months of age, or earlier in areas of high endemicity (22). Previous studies to assess the immune response to pertussis vaccines or B. pertussis infection have employed agglutination-type assays (1,2,8,12,13,16,27,30,40,41), complement fixation (7,23,24), bactericidal assays (3), and enzyme-linked immunosorbent assays (ELISA) (17,33,39). Since whole cells or disrupted whole cell preparations were used as antigens in these assays, it VOL.…”

mentioning

confidence: 99%

Serological response to filamentous hemagglutinin and lymphocytosis-promoting toxin of Bordetella pertussis

Burstyn¹,

Baraff²,

Peppler³

et al. 1983

Infect Immun

101

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Serum antibody responses to the filamentous hemagglutinin and the lymphocytosis-promoting toxin of Bordetella pertussis after vaccination with diphtheria and tetanus toxoids and pertussis vaccine, adsorbed, were assayed by using the enzyme-linked immunosorbent assay. The effect of early immunization, during the first week of life, on the antibody response also was determined. After vaccination, immunoglobulin G (IgG) and IgM directed against both the filamentous hemagglutinin and the lymphocytosis-promoting toxin were detected. Generally, antibody titers increased with subsequent injections and the age of the children. Maternal antibodies against filamentous hemagglutinin and lymphocytosis-promoting toxin were detected in cord blood. The ability of an infant to produce serum IgG anti-lymphocytosis-promoting toxin after vaccination with pertussis vaccine was inversely related to the cord blood serum IgG antilymphocytosis-promoting toxin titer at birth. A good antibody response was observed in infants with low cord blood titers, and a poor antibody response was seen in infants with high cord blood values. The IgM anti-lymphocytosispromoting toxin response was good in groups with both low and high cord blood titer, with no significant difference observed between the two groups. No IgA anti-lymphocytosis-promoting toxin or IgA anti-filamentous hemagglutinin titers were observed in vaccinees. IgA antibodies were observed in convalescent sera from two adults and may be presumptive evidence of infection with B. pertussis.

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