2023
DOI: 10.21203/rs.3.rs-2711013/v1
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Perturbations in the ligand-receptor interactions unravel novel heterogeneous subtypes of stage II/III colorectal cancer

Abstract: Approximately 10%-15% of stage II and 25%-30% of stage III colorectal cancer (CRC) patients experience recurrence within five years after surgery, while existing taxonomies are inadequate for daily clinical application. Therefore, a more reliable classification approach with higher accuracy and prognostic potential is urgently required to stratify stage II/III CRC and identify potential patients who will benefit from postoperative adjuvant therapy. Alternatively, interactions of ligand-receptor pairs point to … Show more

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