Perturbational cortical complexity evoked by thalamic versus motor cortex stimulation

Casas-Torremocha, Diana; Cortada, Martina; Camassa, Alessandra; Tort-Colet, Núria; Destexhe, Alain; Sánchez-Vives, María V.

doi:10.1016/j.brs.2023.01.798

Cited by 1 publication

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“…This raises the question: does CT activation favour complex propagation of cortical perturbations? Of note, a recent mouse model indicated that under anaesthesia, thalamic stimulation (in the ventral posteromedial thalamic nucleus) elicited a more complex PCI response than stimulation of motor cortex 109 . Bringing together the diversity of existing markers of consciousness into a unified framework represents an ongoing challenge, and will be essential for translational applications to the clinic.…”

Section: Discussionmentioning

confidence: 99%

Local orchestration of distributed functional patterns supporting loss and restoration of consciousness in the primate brain

Luppi,

Uhrig,

Tasserie

et al. 2024

Nat Commun

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A central challenge of neuroscience is to elucidate how brain function supports consciousness. Here, we combine the specificity of focal deep brain stimulation with fMRI coverage of the entire cortex, in awake and anaesthetised non-human primates. During propofol, sevoflurane, or ketamine anaesthesia, and subsequent restoration of responsiveness by electrical stimulation of the central thalamus, we investigate how loss of consciousness impacts distributed patterns of structure-function organisation across scales. We report that distributed brain activity under anaesthesia is increasingly constrained by brain structure across scales, coinciding with anaesthetic-induced collapse of multiple dimensions of hierarchical cortical organisation. These distributed signatures are observed across different anaesthetics, and they are reversed by electrical stimulation of the central thalamus, coinciding with recovery of behavioural markers of arousal. No such effects were observed upon stimulating the ventral lateral thalamus, demonstrating specificity. Overall, we identify consistent distributed signatures of consciousness that are orchestrated by specific thalamic nuclei.

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Section: Discussionmentioning

confidence: 99%