Perturbation of Serotonin Homeostasis during Adulthood Affects Serotonergic Neuronal Circuitry

Pratelli, Marta; Migliarini, Sara; Pelosi, Barbara; Napolitano, Francesco; Usiello, Alessandro; Pasqualetti, Massimo

doi:10.1523/eneuro.0376-16.2017

Cited by 44 publications

(54 citation statements)

References 59 publications

(89 reference statements)

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“…Altogether, these findings indicate that perturbing 5-HT levels during critical periods of early development influences later neuronal development through alteration of CNS connectivity that may persist into the adulthood [13,[21][22][23]. Interestingly, recent evidence demonstrated that changes in 5-HT homeostasis affect axonal branch complexity not only during development but also in the adult life [24]. In adult TPH2-conditional KO mice it was shown that the administration of the serotonin precursor 5-hydroxytryptophan was able to re-establish the 5-HT signaling and to rescue defects in serotonergic system organization [24].…”

Section: Role Of Serotonin In Morphological Remodeling Of Cns Circuitsmentioning

confidence: 84%

“…Interestingly, recent evidence demonstrated that changes in 5-HT homeostasis affect axonal branch complexity not only during development but also in the adult life [24]. In adult TPH2-conditional KO mice it was shown that the administration of the serotonin precursor 5-hydroxytryptophan was able to re-establish the 5-HT signaling and to rescue defects in serotonergic system organization [24]. Interestingly, in recent elegant experiments that combined chemogenetics and fMRI, it was demonstrated that, in adult mice, endogenous stimulation of 5-HT-producing neurons does not affect global brain activity but selectively activates specific cortical and subcortical areas.…”

Section: Role Of Serotonin In Morphological Remodeling Of Cns Circuitsmentioning

confidence: 99%

See 1 more Smart Citation

Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease

Crispino

Volpicelli

Perrone-Capano

2019

Preprint

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Our knowledge on the plastic functions of the serotonin (5-HT) receptor subtype 7 (5-HT7R) in the brain physiology and pathology considerably advanced in the last few years. A wealth of data show that the 5-HT7R is a key player in the establishment and remodeling of neuronal cytoarchitecture during development and in the mature brain, and its dysfunction is linked to neuropsychiatric and neurodevelopmental diseases. The involvement of this receptor in synaptic plasticity is further demonstrated by data showing that its activation allows to rescue long term potentiation (LTP) and long term depression (LTD) deficits in various animal models of neurodevelopmental diseases. In addition, it is becoming clear that the 5-HT7R is involved in inflammatory intestinal diseases, possibly playing a role in the gut-brain axis, and modulates the function of immune cells. In this review, we will mainly focus on recent findings on this receptor’s role in the structural and synaptic plasticity of the mammalian brain, although we will also illustrate novel aspects highlighted in gut and immune system.

show abstract

Section: Role Of Serotonin In Morphological Remodeling Of Cns Circuitsmentioning

confidence: 84%

Section: Role Of Serotonin In Morphological Remodeling Of Cns Circuitsmentioning

confidence: 99%

Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease

Crispino

Volpicelli

Perrone-Capano

2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Altogether, these findings indicate that perturbing 5-HT levels during critical periods of early development influences later neuronal development through alteration of CNS connectivity that may persist into the adulthood [17,25,26]. Interestingly, recent evidence demonstrated that changes in 5-HT homeostasis affect axonal branch complexity, not only during development but also in adult life [27]. In adult TPH2-conditional KO mice it was shown that the administration of the serotonin precursor 5-hydroxytryptophan was able to re-establish the 5-HT signaling and to rescue defects in serotonergic system organization [27].…”

Section: Role Of Serotonin In Morphological Remodeling Of Cns Circuitsmentioning

confidence: 86%

Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease

Crispino

Volpicelli

Perrone-Capano

2020

IJMS

View full text Add to dashboard Cite

Our knowledge on the plastic functions of the serotonin (5-HT) receptor subtype 7 (5-HT7R) in the brain physiology and pathology have advanced considerably in recent years. A wealth of data show that 5-HT7R is a key player in the establishment and remodeling of neuronal cytoarchitecture during development and in the mature brain, and its dysfunction is linked to neuropsychiatric and neurodevelopmental diseases. The involvement of this receptor in synaptic plasticity is further demonstrated by data showing that its activation allows the rescue of long-term potentiation (LTP) and long-term depression (LTD) deficits in various animal models of neurodevelopmental diseases. In addition, it is becoming clear that the 5-HT7R is involved in inflammatory intestinal diseases, modulates the function of immune cells, and is likely to play a role in the gut-brain axis. In this review, we will mainly focus on recent findings on this receptor’s role in the structural and synaptic plasticity of the mammalian brain, although we will also illustrate novel aspects highlighted in gastrointestinal (GI) tract and immune system.

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“…This ensures an easy and high fidelity visualization of the fine-grain anatomy of the whole 5-HT system, which already allowed us to study different aspects of 5-HT fiber dynamics, both in vitro and in vivo , as well as during mouse development and in adulthood (Migliarini et al, 2013; Pelosi et al, 2015; Pacini et al, 2017; Pratelli et al, 2017). We combined GFP immunofluorescence with confocal microscope imaging and 3D-reconstruction to quantitatively characterize the post-natal development of serotonergic fibers in selected brain regions.…”

Section: Introductionmentioning

confidence: 99%

Development of Serotonergic Fibers in the Post-Natal Mouse Brain

Maddaloni

Bertero

Pratelli

et al. 2017

Front. Cell. Neurosci.

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Serotonin (5-HT)-synthetizing neurons, which are confined in the raphe nuclei of the rhombencephalon, provide a pervasive innervation of the central nervous system (CNS) and are involved in the modulation of a plethora of functions in both developing and adult brain. Classical studies have described the post-natal development of serotonergic axons as a linear process of terminal field innervation. However, technical limitations have hampered a fine morphological characterization. With the advent of genetic mouse models, the possibility to label specific neuronal populations allowed the rigorous measurement of their axonal morphological features as well as their developmental dynamics. Here, we used the Tph2GFP knock-in mouse line, in which GFP expression allows punctual identification of serotonergic neurons and axons, for confocal microscope imaging and we performed 3-dimensional reconstruction in order to morphologically characterize the development of serotonergic fibers in specified brain targets from birth to adulthood. Our analysis highlighted region-specific developmental patterns of serotonergic fiber density ranging from a linear and progressive colonization of the target (Caudate/Putamen, Basolateral Amygdala, Geniculate Nucleus and Substantia Nigra) to a transient increase in fiber density (medial Prefrontal Cortex, Globus Pallidus, Somatosensory Cortex and Hippocampus) occurring with a region-specific timing. Despite a common pattern of early post-natal morphological maturation in which a progressive rearrangement from a dot-shaped to a regular and smooth fiber morphology was observed, starting from post-natal day 28 serotonergic fibers acquire the region specific morphological features present in the adult. In conclusion, we provided novel, target-specific insights on the morphology and temporal dynamics of the developing serotonergic fibers.

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Perturbation of Serotonin Homeostasis during Adulthood Affects Serotonergic Neuronal Circuitry

Abstract: Visual Abstract

Cited by 44 publications

References 59 publications

Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease

Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease

Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease

Development of Serotonergic Fibers in the Post-Natal Mouse Brain

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