Perturbation of 3-tert-butyl-4-hydroxyanisole in adipogenesis of male mice with normal and high fat diets

Sun, Zhendong; Zhi, Tian; Yang, Xiaoxi; Liu, Qian S.; Liang, Yong; Fiedler, Heidelore; Zhang, Jianqing; Zhou, Qunfang; Jiang, Guibin

doi:10.1016/j.scitotenv.2019.135608

Cited by 30 publications

(44 citation statements)

References 47 publications

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“…The distribution of adipocyte area (Figure c) and mean adipocyte area (Figure d) as quantified by measuring no less than 2200 adipocytes from six mice in each group also showed that adipocytes in the obese mice were about 1.9 fold more than those in normal mice. These results were in accordance with previous studies that ingestion of an HFD led to eWAT accumulation and inflammation. , …”

Section: Resultssupporting

confidence: 94%

“…These results were in accordance with previous studies that ingestion of an HFD led to eWAT accumulation and inflammation. 43,44 Nanosilver administrations showed little effect on eWAT weight or adipocyte area of either normal or obese mice (Figure 3a−d) but mitigated the obesity-related inflammation of eWAT (Figure 3b). To further confirm the histological results, we isolated total stromal vascular fraction (SVF) cells of eWAT and determined the expression of CD45 (a leucocyte common antigen) of the isolated cells using flow cytometry.…”

Section: Methodsmentioning

confidence: 99%

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Mitigation of Obesity-Related Systemic Low-Grade Inflammation and Gut Microbial Dysbiosis in Mice with Nanosilver Supplement

Jia

Zhang

et al. 2021

ACS Appl. Bio Mater.

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Systemic low-grade inflammation and imbalance of gut microbiota are important risk factors promoting the progression of obesity-related metabolic disorders. This provides potential pharmacological and nutritional targets for the management of obesity and obesity-related disorders. Here, we evaluated the modulatory effects of nanosilver on obesity-related systemic low-grade inflammation and gut microbial dysbiosis. C57BL/6J mice were fed with normal diet (ND) or high-fat diet (HFD) for 6 months, with/without nanosilver supplementation in drinking water. Nanosilver administration showed little systemic toxicity and did not affect the progression of obesity but mitigated the obesity-related systemic low-grade inflammation in obese mice. Such mitigation of systemic low-grade inflammation was specifically mediated by reducing the inflammatory status of epididymal visceral white adipose tissue (eWAT). Nanosilver treatments increased the diversity of gut microbial communities and markedly recovered the relative abundance of Verrucomicrobia, Epsilonbacteraeota, Actinobacteria, and Deferribacteres, without altering the proportion of Bacteroidetes or Firmicutes. The beneficial effects of nanosilver in obese mice were in association with an increase in Akkermansia but a decrease in Parasutterella at the genus level. This study suggested a potential application of nanosilver in reducing the health risks of obesity.

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Section: Resultssupporting

confidence: 94%

Section: Methodsmentioning

confidence: 99%

Mitigation of Obesity-Related Systemic Low-Grade Inflammation and Gut Microbial Dysbiosis in Mice with Nanosilver Supplement

Jia

Zhang

et al. 2021

ACS Appl. Bio Mater.

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“…Surfactants such as dioctyl sodium sulfosuccinate (DOOS) and Span 80 can activate the PPARγ and RXR receptors, and the combination of these products can induce an increase in adipogenesis. Other chemical compounds used as preservatives, such as 3-tertbutyl-4-hydroxyanisole (3-BHA), induce the differentiation of 3T3-L1 preadipocytes [97], while the flavoring monosodium glutamate (MSG) can promote adipogenesis by modifying the secretion of GLP-1. In addition, some herbicides that remain in use in some countries, such as glyphosate, can induce obesity in the F2 and F3 offspring of females exposed to during gestation [98].…”

Section: Environment and Obesitymentioning

confidence: 99%

Control of Adipose Cell Browning and Its Therapeutic Potential

Lizcano

Arroyave

2020

Metabolites

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Adipose tissue is the largest endocrine organ in humans and has an important influence on many physiological processes throughout life. An increasing number of studies have described the different phenotypic characteristics of fat cells in adults. Perhaps one of the most important properties of fat cells is their ability to adapt to different environmental and nutritional conditions. Hypothalamic neural circuits receive peripheral signals from temperature, physical activity or nutrients and stimulate the metabolism of white fat cells. During this process, changes in lipid inclusion occur, and the number of mitochondria increases, giving these cells functional properties similar to those of brown fat cells. Recently, beige fat cells have been studied for their potential role in the regulation of obesity and insulin resistance. In this context, it is important to understand the embryonic origin of beige adipocytes, the response of adipocyte to environmental changes or modifications within the body and their ability to transdifferentiate to elucidate the roles of these cells for their potential use in therapeutic strategies for obesity and metabolic diseases. In this review, we discuss the origins of the different fat cells and the possible therapeutic properties of beige fat cells.

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“…In addition to surfactants and emulsifiers, the widely used food preservative 3-tert-butyl-4hydroxyanisole (3-BHA) induced adipocyte differentiation in 3T3-L1 preadipocytes (119); moreover, 3-BHA exposure increased adiposity and lipid plasma levels in exposed mice (120).…”

Section: Food Additivesmentioning

confidence: 99%

“…In addition to surfactants and emulsifiers, the widely used food preservative 3-tert-butyl-4-hydroxyanisole (3-BHA) induced adipocyte differentiation in 3T3-L1 preadipocytes ( 118 ); moreover, 3-BHA exposure increased adiposity and lipid plasma levels in exposed mice ( 119 ). The flavor enhancer monosodium glutamate (MSG) is well-known for its action to induce obesity and metabolic abnormalities in mice by its toxic effects on the arcuate nucleus, a critical hypothalamic nucleus involved in body mass and energy metabolism regulation ( 120 , 121 , 122 , 123 ).…”

Section: Obesogens Old and Newmentioning

confidence: 99%

Obesity and endocrine-disrupting chemicals

Amato

Wheeler

Blumberg

2021

Endocrine Connections

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Obesity is now a worldwide pandemic. The usual explanation given for the prevalence of obesity is that it results from consumption of a calorie dense diet coupled with physical inactivity. However, this model inadequately explains rising obesity in adults and in children over the past few decades, indicating that other factors must be important contributors. An Endocrine-Disrupting Chemical (EDC) is an exogenous chemical, or mixture that interferes with any aspect of hormone action. EDCs have become pervasive in our environment, allowing humans to be exposed daily through ingestion, inhalation, and direct dermal contact. Exposure to EDCs has been causally linked with obesity in model organisms and associated with obesity occurrence in humans. Obesogens are chemicals, including some EDCs that promote adipogenesis and obesity, in vivo, by a variety of mechanisms. The environmental obesogen model holds that exposure to obesogens elicits a predisposition to obesity and that such exposures may be an important yet overlooked factor in the obesity pandemic. Effects produced by EDCs and obesogen exposure may be passed to subsequent, unexposed generations. This “generational toxicology” is not currently factored into risk assessment by regulators but may be another important factor in the obesity pandemic as well as in the worldwide increases in the incidence of noncommunicable diseases that plague populations everywhere. This review addresses the current evidence on how obesogens affect body mass, discusses long-known chemicals that have been more recently identified as obesogens, and how the accumulated knowledge can help identify EDCs hazards.

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Perturbation of 3-tert-butyl-4-hydroxyanisole in adipogenesis of male mice with normal and high fat diets

Cited by 30 publications

References 47 publications

Mitigation of Obesity-Related Systemic Low-Grade Inflammation and Gut Microbial Dysbiosis in Mice with Nanosilver Supplement

Mitigation of Obesity-Related Systemic Low-Grade Inflammation and Gut Microbial Dysbiosis in Mice with Nanosilver Supplement

Control of Adipose Cell Browning and Its Therapeutic Potential

Obesity and endocrine-disrupting chemicals

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