“…A number of catalysts have been used in one‐pot multicomponent reactions for the synthesis of isoxazol‐5(4 H )‐one scaffolds including boric acid, citric acid, molecular iodine, KI, Ag/SiO 2 , 4‐( N , N‐ dimethylamino) pyridinium acetate, tetrabutylammonium perchlorate/glycine/sodium oxalate, amine‐modified montmorillonite nanoclay, antimony trichloride, mesolite, DABCO functionalized dicationic ionic liquid, nano‐MgO, sodium silicate pentahydrate, citrus fruit juice, pyridinium p‐ toluenesulfonate, cerium chloride heptahydrate, pyridine, nickel (II) acetate and many more . Also, advanced techniques such as microwave heating, grinding, ultrasonic irradiation and visible light in the presence of sodium acetate in aqueous EtOH have also been reported for the preparation of isoxazol‐5(4 H )‐ones, Although many of these protocols suffer from drawbacks and limitations such as low yields/long reaction times, strongly acidic or basic conditions and the use of toxic reagents, stringent reaction conditions, the use of expensive catalyst, multistep synthetic sequence and difficult work up procedures that restrict their scope in practical applications. Considering the above points, we report an efficient and green method for the synthesis of a wide variety of isoxazol‐5(4 H )‐one derivatives via the one‐pot, three‐component process catalyzed by ZnO@Fe 3 O 4 core–shell nanoparticles under aqueous conditions (Scheme ).…”