Perspectives on the Use of Stem Cells for Autism Treatment

Siniscalco, Dario; Bradstreet, James Jeffrey; Sych, Nataliia; Antonucci, Nicola

doi:10.1155/2013/262438

Cited by 25 publications

(27 citation statements)

References 86 publications

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“…The potential application of cell therapy, in particular MSCs, for ASDs has already been discussed by our group [28,29] . After a brief description of MSC-mediated ameliorative effects in ASDs, we will review recent and ongoing clinical trials using MSC transplantation in ASD patients.…”

Section: Mesenchymal Stem Cells In Treating Autism: the Rationalementioning

confidence: 99%

“…We hypothesize that MSCs exert a positive effect in ASDs through the following mechanisms: stimulation of the plastic response in the host damaged tissue (e.g., inflammatory bowel disorders); synthesizing and releas-ing anti-inflammatory cytokines and survival-promoting growth factors (paracrine and biopharmacy); integrating into existing neural and synaptic network (engrafting), and restoring plasticity [28,29] . Following transplantation, MSCs target and migrate to the site of injury.…”

Section: Mesenchymal Stem Cells In Treating Autism: the Rationalementioning

confidence: 99%

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Mesenchymal stem cells in treating autism: Novel insights

Siniscalco

Bradstreet

Sych

et al. 2014

WJSC

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Autism spectrum disorders (ASDs) are complex neurodevelopmental disorders characterized by dysfunctions in social interactions, abnormal to absent verbal communication, restricted interests, and repetitive stereotypic verbal and non-verbal behaviors, influencing the ability to relate to and communicate. The core symptoms of ASDs concern the cognitive, emotional, and neurobehavioural domains. The prevalence of autism appears to be increasing at an alarming rate, yet there is a lack of effective and definitive pharmacological options. This has created an increased sense of urgency, and the need to identify novel therapies. Given the growing awareness of immune dysregulation in a significant portion of the autistic population, cell therapies have been proposed and applied to ASDs. In particular, mesenchymal stem cells (MSCs) possess the immunological properties which make them promising candidates in regenerative medicine. MSC therapy may be applicable to several diseases associated with inflammation and tissue damage, where subsequent regeneration and repair is necessary. MSCs could exert a positive effect in ASDs through the following mechanisms: stimulation of repair in the damaged tissue, e.g. , inflammatory bowel disease; synthesizing and releasing anti-inflammatory cytokines and survival-promoting growth factors; integrating into existing neural and synaptic network, and restoring plasticity. The paracrine mechanisms of MSCs show interesting potential in ASD treatment. Promising and impressive results have been reported from the few clinical studies published to date, although the exact mechanisms of action of MSCs in ASDs to restore functions are still largely unknown. The potential role of MSCs in mediating ASD recovery is discussed in light of the newest findings from recent clinical studies.

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Section: Mesenchymal Stem Cells In Treating Autism: the Rationalementioning

confidence: 99%

Section: Mesenchymal Stem Cells In Treating Autism: the Rationalementioning

confidence: 99%

Mesenchymal stem cells in treating autism: Novel insights

Siniscalco

Bradstreet

Sych

et al. 2014

WJSC

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“…4 Another method of treatment is the use of therapeutic behavior with low and high intensity. 5 In the study performed by Lovaas et al, 6 the intensive therapeutic behavior was tested on 19 four-year-old children for a period of 40 hours during a week.…”

Section: 2mentioning

confidence: 99%

Assessing the effects of newly designed pressure vest on children with autism spectrum disorders

Jamshidi¹,

Pouretemad²

2018

Pol. Ann. Med.

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A i m The aim of this study is to expand the pressure vest therapy as a new non-invasive method to treat the autism spectrum disorder. M a t e r i a l a n d m e t h o d s : Pressure vest have cells dilated to apply pressure to the body and an air compressor manually adjustable for proper functioning. It is needed to apply pressure in a different way to enter some dynamic pressure that has a characteristic rhythmic massage. In this study, we used an alternative treatment plan for five children with autism within seven days of seven weeks. At first, the vest was worn to the baby and then a series of tasks and common games were performed. The Micro had three different programs to control valves of pressure vest. R e s u l t s a n d d i s c u s s i o n : Children in most cases did the exercises and assignments with interest and had more patience. Assessing four main parameters including the focus, anger, learning and speaking in children indicates that at the end of the seven-weak course, the behavior of children has improved in the form of a reduction in the anger level and the improvement of speaking, learning and focus. The device had an acceptable performance in the prevention of sudden behaviors. The major advantage of these vests were increasing focus and concentration, enhancing comprehension and learning and reducing hyperactivity.C o n c l u s i o n s : Further work with a larger database of subjects and different psychological evaluation methods is required to confirm our findings. The Micro three different programs to control valves of pressure vest had no significant effects.

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“…The great appeal (especially in ASDs) of stem cells, however, is due to their strong immunomodulatory capacity (Siniscalco et al 2013c). This property is performed through the paracrine activity; by synthesizing and releasing (secretome activity) key molecules (i.e., anti-inflammatory cytokines) stem cells regulate host immune system cells (i.e., B and T cells).…”

Section: Future Directions: Cellular Therapiesmentioning

confidence: 99%

“…In principle, other stem cell types beyond MSCs could be useful for ASD treatment (Siniscalco et al 2013c). A very important subtype for clinical use is fetal stem cells (FSCs).…”

Section: Future Directions: Cellular Therapiesmentioning

confidence: 99%

Translational Approaches to Autism Spectrum Disorder

Robinson-Agramonte¹

2015

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Perspectives on the Use of Stem Cells for Autism Treatment

Cited by 25 publications

References 86 publications

Mesenchymal stem cells in treating autism: Novel insights

Mesenchymal stem cells in treating autism: Novel insights

Assessing the effects of newly designed pressure vest on children with autism spectrum disorders

Translational Approaches to Autism Spectrum Disorder

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