Perspectives on the In Vivo Location of Cellular Interactions in the Humoral Immune Response

Lumb, Judith Rae

doi:10.1146/annurev.mi.33.100179.002255

Cited by 5 publications

(1 citation statement)

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“…Histological signs of active viral infection were limited to days 3 to 11 post-inoculation, when altered histiocytes were seen in lymphoid tissues with a few cells containing intranuclear inclusions or foci of eosinophilic necrosis. The timing and sequence of T-cell area stimulation, followed by B-cell area activation, observed during guinea pig CMV infection seemed to duplicate the pattern seen in guinea pigs and other species when animals were immunized with any antigen, classically with sheep erythrocytes (12,17,21,22). Lymphoid tissues appeared to differ from the salivary gland in that fully developed intranuclear inclusions were rarely seen in lymphoid tissue, although small inclusions have been observed in the lymph nodes of 3 out of 50 guinea pigs with natural CMV infection (7).…”

Section: Resultsmentioning

confidence: 57%

Cytomegalovirus-induced mononucleosis in guinea pigs

Griffith¹,

Lucia²,

Bia³

et al. 1981

Infect Immun

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The effects of cytomegalovirus (CMV) infection on hematopoietic and lymphoid tissues were studied in guinea pigs. Blood parameters, histopathology, and virus distribution in the bone marrow, spleen, lymph nodes, and thymus were assessed during primary nonlethal acute and chronic guinea pig CMV infection. Transient hematological changes comparable to those seen in human CMV mononucleosis were observed during acute infection. These included anemia and leukocytosis with atypical lymphocytes. Splenomegaly and stimulation of spleen and lymph node T-and B-cell areas were also noted. These changes occurred at the peak of virus recovery from all tissues tested, as well as from macrophages and Band Tcell-enriched spleen subpopulations. Virus was cleared rapidly from blood and bone marrow; blood counts, spleen size, and histology returned to normal within 1 month after virus inoculation. However, guinea pigs failed to eliminate the virus completely from lymphoid tissues, since virus persisted in splenic macrophage and B-lymphocyte-enriched populations during chronic infection. The data suggest that CMV-infected mononuclear cells play a role in the establishment of generalized acute infection and virus persistence.

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Section: Resultsmentioning

confidence: 57%