Perspectives on the Ethics of Antibiotic Overuse and on the Implementation of (New) Antibiotics

Hays, John P.; Alvarez, Maria Josefina Ruiz; Roson-Calero, Natalia; Amin, Rohul; Murugaiyan, Jayaseelan; Dongen, Maarten van

doi:10.1007/s40121-022-00656-2

Cited by 6 publications

(1 citation statement)

References 64 publications

(62 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is crucial to significantly improve public awareness about microorganisms and antibiotic resistance [ 8 ]. Eventually, it is necessary to maintain a steady stream of new structural classes of antibiotics that are unaffected by established or recognized mechanisms of resistance [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antibacterial Activity of Mono- and Bi-Cationic Pyridinium 1,2,4-Oxadiazoles and Triazoles

Amata,

Calà,

Rizzo

et al. 2023

IJMS

View full text Add to dashboard Cite

One of the main causes of mortality in humans continues to be infectious diseases. Scientists are searching for new alternatives due to the fast increase in resistance of some harmful bacteria to the frontline antibiotics. To effectively treat pathogenic infections, it is crucial to design antibiotics that can prevent the development of pathogenic resistance. For this purpose, a set of 39 quaternary pyridinium and bis-pyridinium salts with different lengths of side alkyl or fluorinated chains, heterocyclic spacers, and counter ions were tested on diverse reference bacterial ATCC (American Type Culture Collection) strains, such as S. aureus and E. coli. Subsequently, 6 out of the 39 pyridinium salts showing relevant MIC (Minimum Inhibitory Concentration) values were tested on clinically isolated, resistant strains of S. aureus, S. epidermids, S. haemolyticus, K. pneumoniae, A. baumannii, and P. aeruginosa. Additional tests have been performed to assess if the minimum concentration detected through MIC assay may limit the growth of biofilms.

show abstract

Section: Introductionmentioning

confidence: 99%

Synthesis and Antibacterial Activity of Mono- and Bi-Cationic Pyridinium 1,2,4-Oxadiazoles and Triazoles

Amata,

Calà,

Rizzo

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

Associations between antibiotic exposure and abnormal cardiac enzyme profiles in older Chinese adults

Zheng,

Ni,

Wang

et al. 2023

Environ Sci Pollut Res

View full text Add to dashboard Cite

Treating Mycoplasma genitalium (in pregnancy): a social and reproductive justice concern

McKnight,

Farsides,

Soni

et al. 2024

Monash Bioeth. Rev.

View full text Add to dashboard Cite

Antimicrobial Resistance is a threat to individual and to population health and to future generations, requiring “collective sacrifices” in order to preserve antibiotic efficacy. ‘Who should make the sacrifices?’ and ‘Who will most likely make them?’ are ethical concerns posited as potentially manageable through Antimicrobial Stewardship. Antimicrobial stewardship almost inevitably involves a form of clinical cost-benefit analysis that assesses the possible effects of antibiotics to treat a diagnosed infection in a particular patient. However, this process rarely accounts properly for patients – above and beyond assessments of potential (non)compliance or adherence to care regimes. Drawing on a vignette of a pregnant woman of colour and migrant diagnosed with Mycoplasma genitalium, a sexually transmissible bacterium, this article draws out some of the ethical, speculative, and practical tensions and complexities involved in Antimicrobial Stewardship. We argue that patients also engage in a form of cost-benefit analysis influenced by experiences of reproductive and social (in)justice and comprising speculative variables - to anticipate future possibilities. These processes have the potential to have effects above and beyond the specific infection antimicrobial stewardship was activated to address. We contend that efforts to practice and research antimicrobial stewardship should accommodate and incorporate these variables and acknowledge the structures they emerge with(in), even if their components remain unknown. This would involve recognising that antimicrobial stewardship is intricately connected to other social justice issues such as immigration policy, economic justice, access to appropriate medical care, racism, etc.

show abstract

Perspectives on the Ethics of Antibiotic Overuse and on the Implementation of (New) Antibiotics

Cited by 6 publications

References 64 publications

Synthesis and Antibacterial Activity of Mono- and Bi-Cationic Pyridinium 1,2,4-Oxadiazoles and Triazoles

Synthesis and Antibacterial Activity of Mono- and Bi-Cationic Pyridinium 1,2,4-Oxadiazoles and Triazoles

Associations between antibiotic exposure and abnormal cardiac enzyme profiles in older Chinese adults

Treating Mycoplasma genitalium (in pregnancy): a social and reproductive justice concern

Contact Info

Product

Resources

About