Perspectives on the Efficacy of Antidepressants for Child and Adolescent Depression

Raz, Amir

doi:10.1371/journal.pmed.0030009

Cited by 30 publications

(35 citation statements)

References 78 publications

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“…In particular, nearly half of the studies concerned psychotropic drugs. This fact is likely due to the ongoing debate regarding the safety and efficacy of psychotropic drugs in the paediatric population and to the concerns associated with the increased use of these drugs [32,33]. Moreover, 30% of the studies concerned antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Drug prescriptions to outpatient children: a review of the literature

Clavenna

Bonati

2009

Eur J Clin Pharmacol

105

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Purpose To evaluate the drug prescription pattern in outpatient children. Methods A systematic literature search was performed in MEDLINE and EMBASE to identify studies published between 1994 and 2008 evaluating drug prescriptions to outpatient children. Results A total of 128 drug utilisation studies were identified, 107 of which were focused on a specific drug class, in particular psychotropic drugs (49 studies) and antibiotics (32 studies). The 21 studies that evaluated all drug prescriptions involved 21 countries, mainly from Europe (13 studies). Large differences were found between studies concerning data source, sample size and age range. A prevalence ranging from 51% in Denmark to 70% in Greenland and a prescription rate (number of drugs per children) ranging from 0.8 in Norway to 3.2 in the United States were reported in the 11 studies that monitored the overall paediatric population. The prevalence rate was higher in preschoolers, with a peak between 72 and 90%, and decreased in children >6 years. Antibiotics were the most prescribed drugs (20-33% of the prescriptions) followed by antiasthmatics (10-25%). According to the results of four studies comparable in terms of data source and children's age, the overall prevalence estimate was 60%. Conclusion A large heterogeneity was found between studies, making a comparative evaluation often difficult or incomplete. The epidemiological evaluation of drug use in children should therefore be improved, in particular in terms of methodological quality of studies, and prospective multinational collaborative studies aimed at collecting valid and comparable data should be performed to improve the rational use of drugs.

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Section: Discussionmentioning

confidence: 99%

Drug prescriptions to outpatient children: a review of the literature

Clavenna

Bonati

2009

Eur J Clin Pharmacol

105

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“…In such a context, the fact that clomipramine is among the ten most prescribed psychotropic drugs in children below 5 years of age is a significant source of concern. On the contrary, the efficacy of pharmacological therapies for MDD in children and adolescents is controversial [41]. A systematic review of the literature did not find a statistically significant difference between tricyclic antidepressants and placebo [26].…”

Section: Discussionmentioning

confidence: 99%

Use of psychotropic medications in Italian children and adolescents

et al. 2006

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Even though the prevalence of psychotropic drug prescriptions in Italian children is lower than that reported in other countries (e.g. United States, Canada, Netherlands, UK), the increase in antidepressant prescriptions raises some concerns. Data concerning safety and efficacy of these antidepressants in pediatrics are still limited and further studies are needed to guarantee evidence based therapeutic approaches in children, adolescents and their families.

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“…taken an SSRI or SNRI over the last ten years [3]. In the present author's practice setting at a large university counseling service, nearly fifty percent of the generally high-functioning and sexually active or sexually motivated young adult clientele are taking psychotropic medications, usually SSRIs or SNRIs [M. Harris, Clinical Director, University of Iowa Counseling Service personal communication, Dec. 5,2007].…”

Section: Introductionmentioning

confidence: 99%

Persistence of Sexual Dysfunction Side Effects after Discontinuation of Antidepressant Medications: Emerging Evidence

Bahrick

2008

TOPSYJ

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Post-market prevalence studies have found that Selective Serotonin Reuptake Inhibitor (SSRI) and SerotoninNorepinephrine Reuptake Inhibitor (SNRI) sexual side effects occur at dramatically higher rates than initially reported in pre-market trials. Prescribing and practice conventions rest on the untested assumption that individuals who develop sexual dysfunction secondary to SSRI and SNRI antidepressant medications return fully to their pre-medication sexual functioning baseline shortly after discontinuing treatment. Most individuals probably do return to their previous level of sexual functioning, however recent case reports, consumer-provided Internet-based information, incidental research findings, and empirical evidence of persistent post SSRI sexual benefits in the premature ejaculation literature suggest that for some individuals, SSRI and SNRI-emergent sexual side effects persist indefinitely after discontinuing the medications. The literature poorly captures the full spectrum of SSRI/SNRI sexual side effects, and a lack of systematic follow-up in the sexual side effects research precludes detection of post SSRI/SNRI sexual dysfunction, leaving the formal knowledge base inadequate and even inaccurate, raising informed consent issues, and leaving clinicians vulnerable to practicing in ways that may be hurtful to patients in spite of their best efforts to inform themselves.

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Perspectives on the Efficacy of Antidepressants for Child and Adolescent Depression

Abstract: Raz looks at the ongoing controversies surrounding the use of SSRI antidepressants in children.

Cited by 30 publications

References 78 publications

Drug prescriptions to outpatient children: a review of the literature

Drug prescriptions to outpatient children: a review of the literature

Use of psychotropic medications in Italian children and adolescents

Persistence of Sexual Dysfunction Side Effects after Discontinuation of Antidepressant Medications: Emerging Evidence

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