Perspectives on the Combined Effects of Ocimum basilicum and Trifolium pratense Extracts in Terms of Phytochemical Profile and Pharmacological Effects

Abstract

Nowadays, the tendency in pharmaceutical and food industries is to replace synthetic antioxidants with the natural ones. For this reason, there is a growing interest in analyzing natural, healthy and non-toxic additives as potential antioxidants. Some plants, which contain high levels of phenolic compounds, present an increasing interest for medicine due to their ability to scavenge free radicals, along with other pharmacological activities, such as antibacterial activity, wound healing and anti-inflammatory effect, to mention only a few. The aim of this review is to explore the therapeutic potential of Ocimum basilicum and Trifolium pratense in relation with their phytochemical profile and to highlight the pharmacological activity of aqueous or ethanol extracts. Special attention was devoted to the dermal pathology and wound healing effects, in the context of multiple skin conditions such as acne, eczema boils, psoriasis and rashes. Additionally, both extracts (Trifolium sp. and Ocimum sp.) are characterized by high content of antioxidant compounds, which are responsible for the radiance and resistance of the skin and slowing down of the aging process by maintaining estrogen levels. Moreover, the potential combined effect of the mixed extract is pointed out in terms of future applications for wound healing, based on some preliminary results obtained from a “scratch tests” assay performed with respect to human dermal fibroblasts.

Evaluation of In Vitro Wound-Healing Potential, Antioxidant Capacity, and Antimicrobial Activity of Stellaria media (L.) Vill

“…The peak from around 0.450 V can be attributed to ascorbic acid oxidation, leading to a content of 0.47 ± 0.003 µg/mL. The value of AEAC was 26 ± 0.02 µg/mL, which indicates an important antioxidant capacity of SM extract, in accordance with other studies employing spectrophotometric methods [14][15][16][17].…”

Investigation of Antioxidant Potential in Ocimum basilicum Flower

“…The results of all activities proof that high content of antioxidant compounds are present in flower of this plant. Flower extract can also be used in future like leaves extracts, for the radiance and resistance of the skin and slowing down of the aging process by maintaining estrogen levels [15].…”

The Effect of Ocimum basilicum L. and Its Main Ingredients on Respiratory Disorders: An Experimental, Preclinical, and Clinical Review

“…The bioactive ingredients of the plant depend on the growth regions ( Driesen et al, 2021 ; Khater et al, 2021 ). The effects of O. basilicum and its derivatives on dermal pathology and wound healing including acne, eczema, boils, psoriasis, and rashes were reported ( Fritea et al, 2021 ).…”