Perspectives on systematic generation of antibiotic resistance with special emphasis on modern antibiotics

I.K, Kavya; Kochhar, Nikita; Ghosh, Anshika; Shrivastava, Shrashti; Singh Rawat, Varunendra; Mondal Ghorai, Soma; Kaur Sodhi, Kushneet; James, Anina; Kumar, Mohit

doi:10.1016/j.totert.2023.100068

Cited by 9 publications

(1 citation statement)

References 150 publications

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“…The cross-resistance occurs when the development of resistance to one antibiotic causes an increase in resistance to another antibiotic in the same class or even against different classes of antibiotics [8]. This phenomenon occurs due to acquired resistance mechanisms, such as genetic mutations of the target site, reduced uptake of the antibiotics, and increased efflux pumps, which confer resistance to one antibiotic and can also confer resistance to other antibiotics with similar structure, function, or target site [9]. The selection of appropriate therapeutic options is severely constrained by this cross-resistance, which in turn renders an increasing number of antibiotics ineffective at treating infections [8,10].…”

Section: Introductionmentioning

confidence: 99%

Ciprofloxacin and Tetracycline Resistance Cause Collateral Sensitivity to Aminoglycosides in Salmonella Typhimurium

Hasan,

Wang,

Ahn

2023

Antibiotics

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The objective of this study was to evaluate collateral sensitivity and cross-resistance of antibiotic-induced resistant Salmonella Typhimurium to various antibiotics. S. Typhimurium ATCC 19585 (STWT) was exposed to ciprofloxacin, gentamicin, kanamycin, and tetracycline to induce antibiotic resistance, respectively, assigned as STCIP, STGEN, STKAN, and STTET. The susceptibilities of the antibiotic-induced resistant mutants to cefotaxime, chloramphenicol, ciprofloxacin, gentamicin, kanamycin, polymyxin B, streptomycin, tetracycline, and tobramycin were determined in the absence and presence of CCCP and PAβN. STCIP showed the cross-resistance to tetracycline and collateral sensitivity to gentamicin (1/2 fold) and kanamycin (1/4 fold). STTET was also cross-resistant to ciprofloxacin (128-fold) and collateral sensitive to gentamicin (1/4-fold) and kanamycin (1/8-fold). The cross-resistance and collateral sensitivity of STCIP and STTET were associated with the AcrAB-TolC efflux pump and outer membrane porin proteins (OmpC). This study provides new insight into the collateral sensitivity phenomenon, which can be used for designing effective antibiotic treatment regimens to control antibiotic-resistant bacteria.

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